SKLB-197

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SKLB-197  纯度: 99.86%

SKLB-197对ATR的IC50值为0.013μM，但对其他402种蛋白激酶的活性非常弱或没有活性。在体外和体内，它对ATM缺陷型肿瘤显示出强大的抗肿瘤活性。

SKLB-197

SKLB-197 Chemical Structure

CAS No. : 2713577-16-1

规格 价格 是否有货 数量
5 mg ￥2600 In-stock
10 mg ￥3800 In-stock
25 mg ￥8000 In-stock
50 mg ￥12800 In-stock
100 mg   询价  
200 mg   询价  

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SKLB-197 相关产品

•相关化合物库:

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生物活性

SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.

IC50 & Target

ATR

0.013 μM (IC50)

分子量

424.50

Formula

C25H24N6O
CAS 号

2713577-16-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Bin H,et al. Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo. Eur J Med Chem. 2022 Feb 12;232:114187

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