TMX-4113

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

TMX-4113 

TMX-4113 是磷酸二酯酶 6D (PDE6D) 和酪蛋白激酶 1α (CK1α) 的降解剂。TMX-4113 可用于癌症研究。

TMX-4113

TMX-4113 Chemical Structure

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生物活性

TMX-4113 is a degrader of phosphodiesterase 6D (PDE6D) and casein kinase 1α (CK1α). TMX-4113 can be used for the research of cancer[1].

IC50 & Target[1]

PDE6D

 

CK1α

 

体外研究
(In Vitro)

TMX-4113 (compound 21; 1 μM; 4 h) shows a high degradation preference for PDE6D and CK1α in MOLT4 cells[1].
TMX-4113 (0 nM, 40 nM, 200 nM, 1µM; 4h) induces degradation of PDE6D in MOLT4 cells[1].
TMX-4113 (0 nM, 40 nM, 200 nM, 1µM; 4h) degrades over 50% of CK1α at a dose of 40 nM in MM.1S cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MOLT4 cells
Concentration: 1 μM
Incubation Time: 4 h
Result: Showed a high degradation preference for PDE6D and CK1α.

Western Blot Analysis[1]

Cell Line: MOLT4 cells
Concentration: 0 nM, 40 nM, 200 nM, 1µM
Incubation Time: 4 h
Result: Induced degradation of PDE6D.

分子量

308.38

Formula

C12H12N4O2S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756.

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