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Dusquetide (Synonyms: SGX942)
Dusquetide (SGX942) 是第一类天然防御调节因子 (IDR)。Dusquetide 通过与 p62 结合调节 PAMPs 和 DAMPs 的天然免疫应答。Dusquetide 在减轻炎症和增加细菌感染清除方面都显示出活性。
Dusquetide Chemical Structure
CAS No. : 931395-42-5
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Dusquetide 的其他形式现货产品:
生物活性 |
Dusquetide (SGX942) is a first-in-class innate defense regulator (IDR). Dusquetide modulates the innate immune response to both PAMPs and DAMPs by binding to p62. Dusquetide shows activity in both reducing inflammation and increasing clearance of bacterial infection[1]. DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular patterns |
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体内研究 (In Vivo) |
Dusquetide (SGX942) (25 mg/kg; i.v.; days 0, 4, 7, 10, and 14) shows no increase in tumor growth or worsening of survival and a trend towards decreased tumor growth and improvement in survival with radiation[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
553.70 |
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Formula |
C25H47N9O5 |
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CAS 号 |
931395-42-5 |
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Sequence Shortening |
RIVPA-NH2 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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