(S,R,S)-AHPC-C3-NH2 TFA(Synonyms: VH032-C3-NH2 TFA)

发表于由

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(S,R,S)-AHPC-C3-NH2 TFA (Synonyms: VH032-C3-NH2 TFA)

(S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 VH032 的 VHL 配体和 1 个 linker。(S,R,S)-AHPC-C3-NH2 可用于合成一系列 PROTAC 分子，如 UNC6852 (HY-130708)。UNC6852 是靶向 EED 的二价化学降解剂。

(S,R,S)-AHPC-C3-NH2 TFA(Synonyms: VH032-C3-NH2 TFA)

(S,R,S)-AHPC-C3-NH2 TFA Chemical Structure

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生物活性

(S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader[1].

IC50 & Target[1]

VHL

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

629.69

Formula

C28H38F3N5O6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15.

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