PI3K/HDAC-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PI3K/HDAC-IN-1 

PI3K/HDAC-IN-1 是一种有效的 (PI3K/HDAC) 双重抑制剂，高效抑制 PI3Kδ 和 HDAC1 的 IC50 值分别为 8.1 nM 和 1.4 nM。

PI3K/HDAC-IN-1

PI3K/HDAC-IN-1 Chemical Structure

CAS No. : 2361418-52-0

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生物活性

PI3K/HDAC-IN-1 is a potent dual inhibitor of PI3K/HDAC, potently inhibits PI3Kδ and HDAC1 with IC50s of 8.1 nM and 1.4 nM, respectively[1].

IC50 & Target

PI3Kα

42 nM (IC50)

PI3Kβ

101 nM (IC50)

PI3Kγ

67 nM (IC50)

PI3Kδ

8.1 nM (IC50)

HDAC1

1.4 nM (IC50)

HDAC2

3.0 nM (IC50)

HDAC6

6.6 nM (IC50)

HDAC8

18 nM (IC50)

分子量

428.46

Formula

C22H25FN4O4
CAS 号

2361418-52-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang K, et al. Design, Synthesis, and Biological Evaluation of 4-Methyl Quinazoline Derivatives as Anticancer Agents Simultaneously Targeting Phosphoinositide 3-Kinases and Histone Deacetylases. J Med Chem. 2019 May 29.

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