Hymeglusin(Synonyms: F-244; 1233A; L-659699)

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Hymeglusin (Synonyms: F-244; 1233A; L-659699) 纯度: ≥98.0%

Hymeglusin 作为一种真菌 β-内酯 antibiotic，是一种 HMG-CoA 合酶抑制剂 (IC50 = 0.12 μM)。 Hymeglusin 共价修饰酶的活性 Cys129 残基。

Hymeglusin(Synonyms: F-244; 1233A; L-659699)

Hymeglusin Chemical Structure

CAS No. : 29066-42-0

规格 价格 是否有货 数量
500 μg ￥7200 In-stock
1 mg ￥11500 In-stock
5 mg   询价  
10 mg   询价  

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生物活性

Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC50 = 0.12 μM). Hymeglusin covalently modifies the active Cys129 residue of the enzyme[2][3].

IC50 & Target

IC50: 1.2 μM (HMG-CoA)[2][3]
体外研究
(In Vitro)

Hymeglusin inhibits dengue type 2 (DEN-2) New Guinea C (NGC) live virus replication in K562 cells. The therapeutic index (CC50/IC50) of Hymeglusin is 11. The EC50 of Hymeglusin in K562 cells is 4.5 μM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

At a dose of 25 mg/kg, hymeglusin inhibits cholesterol biosynthesis in rats by 45 %[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

324.41

Formula

C18H28O5
CAS 号

29066-42-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
参考文献

  • [1]. Rothwell C, et al. Cholesterol biosynthesis modulation regulates dengue viral replication. Virology. 2009 Jun 20;389(1-2):18-19.

    [2]. Greenspan MD, et al. Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699. Proc Natl Acad Sci U S A. 1987 Nov;84(21):7488-92.

    [3]. Tomoda H, et al. Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase. Biochim Biophys Acta. 2004 Feb 27;1636(1):22-8.

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