Azido-PEG3-maleimide

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Azido-PEG3-maleimide 

Azido-PEG3-maleimide 是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。Azido-PEG3-maleimide 也是一种可降解 (cleavable) 的含 3 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。

Azido-PEG3-maleimide

Azido-PEG3-maleimide Chemical Structure

CAS No. : 1858264-36-4

规格 价格 是否有货
25 mg ￥3500 询问价格 & 货期

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生物活性

Azido-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-maleimide is also a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

IC50 & Target[1][2]

PEGs

 

Cleavable

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

369.37

Formula

C15H23N5O6
CAS 号

1858264-36-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Deshmukh AA, et al. Detection of Protease Activity by Fluorescent Peptide Zymography. J Vis Exp. 2019 Jan 20;(143).

    [2]. Allo B, et al. Clickable and High-Sensitivity Metal-Containing Tags for Mass Cytometry. Bioconjug Chem. 2018 Jun 20;29(6):2028-2038.

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