BMVC2(Synonyms: o-BMVC)

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BMVC2 (Synonyms: o-BMVC)

BMVC2 (o-BMVC) 是 BMVC 的双取代咔唑衍生物,是一种 G 四联体 (G4) 稳定剂。

BMVC2(Synonyms: o-BMVC)

BMVC2 Chemical Structure

CAS No. : 850559-51-2

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5 mg ¥2500 询问价格 & 货期
10 mg ¥3800 询问价格 & 货期
25 mg ¥7500 询问价格 & 货期
50 mg ¥12000 询问价格 & 货期
100 mg ¥18000 询问价格 & 货期

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生物活性

BMVC2 (o-BMVC) is a bisubstitute carbazole derivative of BMVC. BMVC2 is a G-quadruplex (G4) stabilizer[1].

IC50 & Target

G-quadruplex[1]

体外研究
(In Vitro)

BMVC2 by monitoring the disappearance of the 291 nm CD signals of d[AG3(T2AG3)3] (HT22) after adding Cu2+ is screened, a longer unfolding time would dictate a better G4 stabilizer. The unfolding curve of HT22 in the presence of BMVC2 can be fitted by using two time constants of 133.7 s (29%) and 2816 s (71%), which are similar to the unfolding parameters of BMVC[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

657.33

Formula

C28H25I2N3

CAS 号

850559-51-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jen-Fei Chu, et al. A Novel Method for Screening G-quadruplex Stabilizers to Human Telomeres. Journal of the Chinese Chemical Society, 2011, 58, 296-300.

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