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L-2-Hydroxyglutaric acid (Synonyms: (S)-2-Hydroxyglutaric acid)
L-2-Hydroxyglutaric acid ((S)-2-Hydroxyglutaric acid) 是一种表观遗传修饰因子，可用于肾癌研究。L-2-Hydroxyglutaric acid 可抑制组蛋白去甲基化酶 (histone demethylases)，从而促进组蛋白甲基化。
L-2-Hydroxyglutaric acid Chemical Structure
CAS No. : 13095-48-2
| 规格 | 价格 | 是否有货 | |
|---|---|---|---|
| 5 mg | ￥2400 | 询问价格 & 货期 | |
| 10 mg | ￥4000 | 询问价格 & 货期 | |
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L-2-Hydroxyglutaric acid 的其他形式现货产品:
| 生物活性 |
L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2]. |
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| IC50 & Target |
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| 体外研究 (In Vitro) |
L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
148.11 |
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| Formula |
C5H8O5 |
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| CAS 号 |
13095-48-2 |
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| 中文名称 |
L-2-羟基戊二酸 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 参考文献 |
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