ATX inhibitor 16

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ATX inhibitor 16 

ATX inhibitor 16 是一种有效的 ATX 抑制剂，IC50 为 0.0021 µM。ATX inhibitor 16 在乳腺癌细胞中显示出优异的抗增殖活性。

ATX inhibitor 16

ATX inhibitor 16 Chemical Structure

CAS No. : 2484811-36-9

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生物活性

ATX inhibitor 16 is a potent ATX inhibitor with an IC50 of 0.0021 µM. ATX inhibitor 16 shows excellent anti-proliferative activities in breast cancer cells[1].

IC50 & Target

IC50: 0.0021 µM (ATX)[1]
体外研究
(In Vitro)

ATX inhibitor 16 (compound 9j) (0-15 µM; 72 h) shows excellent anti-proliferative activities in breast cancer cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: MCF7, MDA-MB-231, A549, H2228 cells
Concentration: 0-15 µM
Incubation Time: 72 h
Result: Exhibited excellent anti-proliferative activities with IC50s of 0.43, 0.31, 10.98, 7.18 µM for MCF7, MDA-MB-231, A549, H2228 cells, respectively.

分子量

584.68

Formula

C28H27F3N6OS2
CAS 号

2484811-36-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lei H,et al. Structure guided design of potent indole-based ATX inhibitors bearing hydrazone moiety with tumor suppression effects. Eur J Med Chem. 2020 Sep 1;201:112456.

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