标签归档：atx

ATX inhibitor 20

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ATX inhibitor 20 

ATX inhibitor 20 (化合物 24) 是一种有效的 ATX 抑制剂，其 IC50 值为 2.3 nM。

ATX inhibitor 20

ATX inhibitor 20 Chemical Structure

CAS No. : 2691937-03-6

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生物活性

ATX inhibitor 20 (compound 24) is a potent ATX (autotaxin) inhibitor, with an IC50 of 2.3 nM[1].

IC50 & Target

Autotaxin

2.3 ± 0.31 nM (IC50)

分子量

543.63

Formula

C31H34FN5O3
CAS 号

2691937-03-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jia F, et al. Structure-based linker exploration: Discovery of 1-ethyl-1H-indole analogs as novel ATX inhibitors. Bioorg Med Chem. 2020 Nov 15;28(22):115795.

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ATX inhibitor 21

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ATX inhibitor 21 

ATX inhibitor 21 (化合物 8) 是一种有效的 ATX 抑制剂，其 IC50 值为 3490 nM。

ATX inhibitor 21

ATX inhibitor 21 Chemical Structure

CAS No. : 2691936-89-5

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生物活性

ATX inhibitor 21 (compound 8) is a potent ATX (autotaxin) inhibitor, with an IC50 of 3490 nM[1].

IC50 & Target

Autotaxin

3490 ± 170 nM (IC50)

分子量

509.57

Formula

C26H25F2N5O2S
CAS 号

2691936-89-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jia F, et al. Structure-based linker exploration: Discovery of 1-ethyl-1H-indole analogs as novel ATX inhibitors. Bioorg Med Chem. 2020 Nov 15;28(22):115795.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ATX inhibitor 19

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ATX inhibitor 19 

ATX inhibitor 19 (化合物 22) 是一种有效的 ATX 抑制剂，其 IC50 值为 156 nM。

ATX inhibitor 19

ATX inhibitor 19 Chemical Structure

CAS No. : 2691937-01-4

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生物活性

ATX inhibitor 19 (compound 22) is a potent ATX (autotaxin) inhibitor, with an IC50 of 156 nM[1].

IC50 & Target

Autotaxin

156 ± 19.8 nM (IC50)

分子量

553.12

Formula

C28H33ClN6O2S
CAS 号

2691937-01-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jia F, et al. Structure-based linker exploration: Discovery of 1-ethyl-1H-indole analogs as novel ATX inhibitors. Bioorg Med Chem. 2020 Nov 15;28(22):115795.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ATX inhibitor 9

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ATX inhibitor 9 

ATX inhibitor 9 是一种有效的 ATX 抑制剂。ATX inhibitor 9 是一种增稠的杂芳基衍生物化合物。Autotaxin (ATX)，也称为 ENPP2，是一种分泌酶，主要在肺癌细胞、支气管上皮细胞和肺泡巨噬细胞中高度表达。ATX inhibitor 9 具有研究癌症或纤维退行性疾病的潜力 (摘自专利 WO2021078227A1，化合物 3)。

ATX inhibitor 9

ATX inhibitor 9 Chemical Structure

CAS No. : 2640300-87-2

规格 是否有货
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生物活性

ATX inhibitor 9 is a potent inhibitor of ATX. ATX inhibitor 9 is a thickened heteroaryl derivatives compound. Autotaxin (ATX), also known as ENPP2, is a secreted enzyme that is highly expressed mainly in cancer cells, bronchial epithelial cells and alveolar macrophages in the lung. ATX inhibitor 9 has the potential for the research of cancer or fibrous degenerative disease (extracted from patent WO2021078227A1, compound 3)[1].

分子量

493.52

Formula

C26H23N9O2
CAS 号

2640300-87-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Xiaomin Zhang, et al. Thickened heteroaryl derivatives, their preparation methods and their application in medicine.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ATX inhibitor 10

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ATX inhibitor 10 

ATX inhibitor 10 是一种有效的 ATX 抑制剂。ATX inhibitor 10是含氮杂环化合物。ATX 在引起包括纤维化、关节炎、神经变性、神经性疼痛和癌症在内的病理状况中发挥作用。ATX inhibitor 10 具有研究ATX相关疾病的潜力 (摘自专利 WO2021115375A1，化合物 35)。

ATX inhibitor 10

ATX inhibitor 10 Chemical Structure

CAS No. : 2648969-30-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

ATX inhibitor 10 is a potent inhibitor of ATX. ATX inhibitor 10 is s nitrogen-containing heterocyclic compound. ATX plays a role in causing pathological conditions including fibrosis, arthritis, neurodegeneration, neuropathic pain, and cancer. ATX inhibitor 10 has the potential for the research of ATX related diseases (extracted from patent WO2021115375A1, compound 35)[1].

分子量

511.46

Formula

C23H20F3N9O2
CAS 号

2648969-30-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Li Yao, et al. Nitrogen-containing heterocyclic autocrine motor factor inhibitors and compositions thereof and uses thereof. Patent WO2021115375A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ATX inhibitor 9

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ATX inhibitor 9 

ATX inhibitor 9 是一种有效的 ATX 抑制剂。ATX inhibitor 9 是一种增稠的杂芳基衍生物化合物。Autotaxin (ATX)，也称为 ENPP2，是一种分泌酶，主要在肺癌细胞、支气管上皮细胞和肺泡巨噬细胞中高度表达。ATX inhibitor 9 具有研究癌症或纤维退行性疾病的潜力 (摘自专利 WO2021078227A1，化合物 3)。

ATX inhibitor 9

ATX inhibitor 9 Chemical Structure

CAS No. : 2640300-87-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

ATX inhibitor 9 is a potent inhibitor of ATX. ATX inhibitor 9 is a thickened heteroaryl derivatives compound. Autotaxin (ATX), also known as ENPP2, is a secreted enzyme that is highly expressed mainly in cancer cells, bronchial epithelial cells and alveolar macrophages in the lung. ATX inhibitor 9 has the potential for the research of cancer or fibrous degenerative disease (extracted from patent WO2021078227A1, compound 3)[1].

分子量

493.52

Formula

C26H23N9O2
CAS 号

2640300-87-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Xiaomin Zhang, et al. Thickened heteroaryl derivatives, their preparation methods and their application in medicine.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ATX inhibitor 10

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ATX inhibitor 10 

ATX inhibitor 10 是一种有效的 ATX 抑制剂。ATX inhibitor 10是含氮杂环化合物。ATX 在引起包括纤维化、关节炎、神经变性、神经性疼痛和癌症在内的病理状况中发挥作用。ATX inhibitor 10 具有研究ATX相关疾病的潜力 (摘自专利 WO2021115375A1，化合物 35)。

ATX inhibitor 10

ATX inhibitor 10 Chemical Structure

CAS No. : 2648969-30-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

ATX inhibitor 10 is a potent inhibitor of ATX. ATX inhibitor 10 is s nitrogen-containing heterocyclic compound. ATX plays a role in causing pathological conditions including fibrosis, arthritis, neurodegeneration, neuropathic pain, and cancer. ATX inhibitor 10 has the potential for the research of ATX related diseases (extracted from patent WO2021115375A1, compound 35)[1].

分子量

511.46

Formula

C23H20F3N9O2
CAS 号

2648969-30-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Li Yao, et al. Nitrogen-containing heterocyclic autocrine motor factor inhibitors and compositions thereof and uses thereof. Patent WO2021115375A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ATX inhibitor 9

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ATX inhibitor 9 

ATX inhibitor 9 是一种有效的 ATX 抑制剂。ATX inhibitor 9 是一种增稠的杂芳基衍生物化合物。Autotaxin (ATX)，也称为 ENPP2，是一种分泌酶，主要在肺癌细胞、支气管上皮细胞和肺泡巨噬细胞中高度表达。ATX inhibitor 9 具有研究癌症或纤维退行性疾病的潜力 (摘自专利 WO2021078227A1，化合物 3)。

ATX inhibitor 9

ATX inhibitor 9 Chemical Structure

CAS No. : 2640300-87-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

ATX inhibitor 9 is a potent inhibitor of ATX. ATX inhibitor 9 is a thickened heteroaryl derivatives compound. Autotaxin (ATX), also known as ENPP2, is a secreted enzyme that is highly expressed mainly in cancer cells, bronchial epithelial cells and alveolar macrophages in the lung. ATX inhibitor 9 has the potential for the research of cancer or fibrous degenerative disease (extracted from patent WO2021078227A1, compound 3)[1].

分子量

493.52

Formula

C26H23N9O2
CAS 号

2640300-87-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Xiaomin Zhang, et al. Thickened heteroaryl derivatives, their preparation methods and their application in medicine.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ATX inhibitor 10

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ATX inhibitor 10 

ATX inhibitor 10 是一种有效的 ATX 抑制剂。ATX inhibitor 10是含氮杂环化合物。ATX 在引起包括纤维化、关节炎、神经变性、神经性疼痛和癌症在内的病理状况中发挥作用。ATX inhibitor 10 具有研究ATX相关疾病的潜力 (摘自专利 WO2021115375A1，化合物 35)。

ATX inhibitor 10

ATX inhibitor 10 Chemical Structure

CAS No. : 2648969-30-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

ATX inhibitor 10 is a potent inhibitor of ATX. ATX inhibitor 10 is s nitrogen-containing heterocyclic compound. ATX plays a role in causing pathological conditions including fibrosis, arthritis, neurodegeneration, neuropathic pain, and cancer. ATX inhibitor 10 has the potential for the research of ATX related diseases (extracted from patent WO2021115375A1, compound 35)[1].

分子量

511.46

Formula

C23H20F3N9O2
CAS 号

2648969-30-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Li Yao, et al. Nitrogen-containing heterocyclic autocrine motor factor inhibitors and compositions thereof and uses thereof. Patent WO2021115375A1.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ATX inhibitor 16

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ATX inhibitor 16 

ATX inhibitor 16 是一种有效的 ATX 抑制剂，IC50 为 0.0021 µM。ATX inhibitor 16 在乳腺癌细胞中显示出优异的抗增殖活性。

ATX inhibitor 16

ATX inhibitor 16 Chemical Structure

CAS No. : 2484811-36-9

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250 mg   询价  
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生物活性

ATX inhibitor 16 is a potent ATX inhibitor with an IC50 of 0.0021 µM. ATX inhibitor 16 shows excellent anti-proliferative activities in breast cancer cells[1].

IC50 & Target

IC50: 0.0021 µM (ATX)[1]
体外研究
(In Vitro)

ATX inhibitor 16 (compound 9j) (0-15 µM; 72 h) shows excellent anti-proliferative activities in breast cancer cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: MCF7, MDA-MB-231, A549, H2228 cells
Concentration: 0-15 µM
Incubation Time: 72 h
Result: Exhibited excellent anti-proliferative activities with IC50s of 0.43, 0.31, 10.98, 7.18 µM for MCF7, MDA-MB-231, A549, H2228 cells, respectively.

分子量

584.68

Formula

C28H27F3N6OS2
CAS 号

2484811-36-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lei H,et al. Structure guided design of potent indole-based ATX inhibitors bearing hydrazone moiety with tumor suppression effects. Eur J Med Chem. 2020 Sep 1;201:112456.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ATX inhibitor 17

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ATX inhibitor 17 

ATX inhibitor 17 是一种有效的 ATX 抑制剂，IC50 为 0.019 µM。 ATX inhibitor 17 在乳腺癌细胞中显示出优异的抗增殖活性。

ATX inhibitor 17

ATX inhibitor 17 Chemical Structure

CAS No. : 2750152-64-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

ATX inhibitor 17 is a potent ATX inhibitor with an IC50 of 0.019 µM. ATX inhibitor 17 shows excellent anti-proliferative activities in breast cancer cells[1].

IC50 & Target

IC50: 0.019 µM (ATX)[1]
体外研究
(In Vitro)

ATX inhibitor 17 (compound 25a) (0-15 µM; 72 h) shows excellent anti-proliferative activities in breast cancer cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: MCF7, MDA-MB-231, A549, H2228 cells
Concentration: 0-15 µM
Incubation Time: 72 h
Result: Showed excellent antiproliferative effects with IC50s of 1.01, 0.79, 13.40, >15 µM for MCF7, MDA-MB-231, A549, H2228 cells, respectively.

分子量

616.65

Formula

C29H29F5N8S
CAS 号

2750152-64-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lei H,et al. Structure guided design of potent indole-based ATX inhibitors bearing hydrazone moiety with tumor suppression effects. Eur J Med Chem. 2020 Sep 1;201:112456.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ATX inhibitor 13

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ATX inhibitor 13 

ATX inhibitor 13 (compound 10c) 是一种口服有效的 ATX 抑制剂，其IC50 为 3.4 nM。ATX inhibitor 13 抑制 RAW264.7 细胞的增殖和迁移，诱导细胞凋亡和 G2 期阻滞。ATX inhibitor 13 抑制肿瘤细胞集落形成。

ATX inhibitor 13

ATX inhibitor 13 Chemical Structure

CAS No. : 2485779-34-6

规格 是否有货
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250 mg   询价  
500 mg   询价  

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生物活性

ATX inhibitor 13 (10c) is an orally active and potent ATX inhibitor, with an IC50 of 3.4 nM. ATX inhibitor 13 inhibits proliferation and migration, and induces apoptosis and G2 phase arrest in RAW264.7 cells. ATX inhibitor 13 suppresses tumor cell colony formation[1].

IC50 & Target

ATX

3.4 nM (IC50)

体外研究
(In Vitro)

ATX inhibitor 13 (compound 10c) (0-20 μM, 72 h) shows cytotoxicity and anti-proliferative activity against MCF-7, MDA-MB-231, A549, NCI-H1581, H2228, Hep3B, and RAW264.7 cells[1].
ATX inhibitor 13 (0-1 μM, 0-72 h) inhibits migration of RAW264.7 cells in a dose-dependent manner, significantly down-regulates both the colony count and colony single area with the concentration elevation[1].
ATX inhibitor 13 (0-1 μM, 72 h) dose dependently suppresses colony formation of RAW264.7 cells[1].
ATX inhibitor 13 (0-1 μM, 48 h) induces weak apoptosis in a dose-dependent manner in RAW264.7 cells[1].
ATX inhibitor 13 (0-1 μM, 48 h) brings G2 phase arrest of RAW264.7 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line: MCF-7, MDA-MB-231, A549, NCI-H1581, H2228, Hep3B, RAW264.7[1]
Concentration: 0-20 μM
Incubation Time: 72 h
Result: Showed cytotoxicity and antiproliferative activity against MCF-7, MDA-MB-231, A549, NCI-H1581, H2228, Hep3B, and RAW264.7 cell lines, with IC50 values of 3.87 ± 0.37, 3.29 ± 0.37, 6.59 ± 0.26, 4.76 ± 0.57, 4.27 ± 0.21, 0.58 ± 0.11, and 0.63 ± 0.26 μM.

Apoptosis Analysis

Cell Line: RAW264.7 cells[1]
Concentration: 0 μM, 0.1 μM, 0.25 μM, 0.5 μM and 1 μM
Incubation Time: 48 h
Result: Induced apoptosis in a dose-dependent manner, with the apoptotic rates of 6.48% (0.1 μM), 7.73% (0.25 μM), 8.60% (0.5 μM) and 9.17% (1 μM).

Cell Cycle Analysis

Cell Line: RAW264.7 cells[1]
Concentration: 0 μM, 0.1 μM, 0.25 μM, 0.5 μM and 1 μM
Incubation Time: 24 h
Result: Led to significant G2 phase arrest in RAW264.7 cells in a dose-dependent manner, the percentage of cells in the G2 phase slightly increased from 10.90% to 90.16% (0-1 μM).

体内研究
(In Vivo)

ATX inhibitor 13 (compound 10c) (C57BL/6J mice, 0-1000 mg/kg, Orally, once) has an acceptable safety profile[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (5 groups,4 mice per group)[1]
Dosage: 5000, 3200, 2500 and 1000 mg/kg
Administration: Orally, once
Result: Had an acceptable safety profile, showed no obvious safety concerns.

分子量

596.55

Formula

C31H35Cl2N5O3
CAS 号

2485779-34-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lei H, et al. Design, synthesis and promising anti-tumor efficacy of novel imidazo[1,2-a]pyridine derivatives as potent autotaxin allosteric inhibitors. Eur J Med Chem. 2022;236:114307.

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ATX inhibitor 1

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ATX inhibitor 1  纯度: 99.75%

ATX inhibitor 1是有效的 ATX (IC50=1.23 nM, FS-3; 2.18 nM, bis-pNPP) 抑制剂。

ATX inhibitor 1

ATX inhibitor 1 Chemical Structure

CAS No. : 2225892-70-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥2650 In-stock
5 mg ￥2400 In-stock
10 mg ￥3800 In-stock
50 mg ￥9800 In-stock
100 mg ￥14000 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

ATX inhibitor 1 相关产品

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生物活性

ATX inhibitor 1 is a potent ATX (IC50=1.23 nM, FS-3 and 2.18 nM, bis-pNPP) inhibitor.

IC50 & Target

IC50: 1.23 nM (FS-3) and 2.18 nM (bis-pNPP)[1]
分子量

501.30

Formula

C21H23Cl2N2O6P
CAS 号

2225892-70-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 250 mg/mL (498.70 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9948 mL 9.9741 mL 19.9481 mL
5 mM 0.3990 mL 1.9948 mL 3.9896 mL
10 mM 0.1995 mL 0.9974 mL 1.9948 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.15 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.15 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.15 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.15 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.15 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (4.15 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Balupuri A, et al. Discovery and optimization of ATX inhibitors via modeling, synthesis and biological evaluation. Eur J Med Chem. 2018 Mar 25;148:397-409.

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