CQ211

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CQ211 

CQ211 是一种有效的、选择性的 RIOK2 抑制剂，Kd 值为 6.1 nM。CQ211 对多种癌细胞均有明显的增殖抑制活性。

CQ211

CQ211 Chemical Structure

CAS No. : 2648986-65-4

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生物活性

CQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM. CQ211 exhibits potent proliferation inhibition activity against multiple cancer cell lines[1].

IC50 & Target

Kd: 6.1 nM (RIOK2)[1]
体内研究
(In Vivo)

CQ211 (25 mg/kg) inhibits the tumor progression with tumor growth inhibition (TGI) of 30.9% in rats[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

521.49

Formula

C26H22F3N7O2
CAS 号

2648986-65-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ouyang Y, et al. Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro-4H-[1,2,3]triazolo[4,5-c]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor. J Med Chem. 2022 Jun 9;65(11):7833-7842.

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