LSD1-IN-21

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

LSD1-IN-21 

LSD1-IN-21 (化合物 5a) 是一种有效的可透过血脑屏障的 LSD1 (赖氨酸特异性去甲基化酶 -1) 抑制剂，其 IC50 为 0.956 µM。LSD1-IN-21 显著降低促炎细胞因子 TNF-α。LSD1-IN-21 具有良好的抗癌和抗炎活性。

LSD1-IN-21

LSD1-IN-21 Chemical Structure

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生物活性

LSD1-IN-21 (compound 5a) is a potent and BBB-penetrated LSD1 (Lysine specific demethylase-1) inhibitor, with an IC50 of 0.956 µM. LSD1-IN-21 significantly reduces the pro-inflammatory cytokine TNF-α. LSD1-IN-21 shows good anticancer and anti-inflammatory activity[1].

IC50 & Target

TNF-α

 

体外研究
(In Vitro)

LSD1-IN-21 (compound 5a) shows potent anti-cancer activity with GI50 values of 0.414 and 0.417 µM against HOP-62 and OVCAR-4 cell lines, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

447.55

Formula

C24H25N5O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Tasneem S, et al. Synthesis, biological evaluation and docking studies of methylene bearing cyanopyrimidine derivatives possessing a hydrazone moiety as potent Lysine specific demethylase-1 (LSD1) inhibitors: A promising anticancer agents. Bioorg Chem. 2022 May 21;126:105885.

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