Limonene is a monoterpene in citrus peel oil. A popular disinfectant and food preservative. Antimicrobial activities^[1]. Anti-proliferative activities^[2]. Antioxidant and anti-inflammatory effect^[3].

Bacterial^[1]

Acute toxicity to limonene is largely due to the common oxidation product limonene-hydroperoxide. The mutant protein AhpCL177Q 35 is able to alleviate this toxicity by reducing the hydroperoxide to a more benign compound^[1].

Limonene exerts anti-proliferative action on a lymphoma cell line without modifying normal lymphocyte viability^[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Limonene (50-100 mg/kg) exerts gastroprotection through local mucosal defense mechanisms, such as increasing the mucus production, modulation of the oxidative stress and inflammatory response and inhibition of Nf-κb expression^[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

136.23

C₁₀H₁₆

138-86-3

• Terpenoids
• Other Monoterpenes

• Plants
• Rutaceae
• Citrus reticulata Blanco

Room temperature in continental US; may vary elsewhere.

• [1]. Chubukov V, et al. Acute Limonene Toxicity in Escherichia coli Is Caused by Limonene Hydroperoxide and Alleviated by a Point Mutation in Alkyl Hydroperoxidase AhpC. Appl Environ Microbiol. 2015 Jul;81(14):4690-6.

  [2]. Roberto D, et al. Antioxidant activity of limonene on normal murine lymphocytes: relation to H2O2 modulation and cell proliferation. Basic Clin Pharmacol Toxicol. 2010 Jan;106(1):38-44.

  [3]. de Souza MC, et al. Gastroprotective effect of limonene in rats: Influence on oxidative stress, inflammation and gene expression. Phytomedicine. 2018 Sep 4;53:37-42.