8-Chloro-cAMP

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8-Chloro-cAMP 

8-Chloro-cAMP 是一种 cAMP 类似物，可诱导生长停滞，并调节 cAMP 依赖性 PKA 活性。8-Chloro-cAMP 具有抗癌活性。

8-Chloro-cAMP

8-Chloro-cAMP Chemical Structure

CAS No. : 41941-56-4

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5 mg ￥13800 In-stock
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生物活性

8-Chloro-cAMP is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent PKA activity. 8-Chloro-cAMP has anticancer activity[1].

体外研究
(In Vitro)

8-Chloro-cAMP markedly inhibits vascular smooth muscle cell (VSMC) proliferation in vitro, reduces protein kinase A (PKA) RIα subunit expression, and induces PKA RIIβ subunit expression[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

In rat bearing balloon injury, 8-Chloro-cAMP (12 mg/kg) reduces, in a dose-dependent manner, neointimal area and neointima/media ratio after balloon injury. 8-Chloro-cAMP shows a reduction of proliferative activity of VSMCs in vivo[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

363.65

Formula

C10H11ClN5O6P
CAS 号

41941-56-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. C Indolfi, et al. 8-chloro-cAMP inhibits smooth muscle cell proliferation in vitro and neointima formation induced by balloon injury in vivo. J Am Coll Cardiol. 2000 Jul;36(1):288-93.

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