Brivudine (Synonyms: 溴夫定; Bromovinyldeoxyuridine; BVDU)
Brivudine是具有抗病毒活性的胸苷类似物,用于早期急性带状疱疹的研究。
Brivudine Chemical Structure
CAS No. : 69304-47-8
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10 mM * 1 mL in DMSO | ¥500 | In-stock | |
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生物活性 |
Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster. |
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体外研究 (In Vitro) |
Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir[1]. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing the period of new blister production, and has shortened the duration of post-herpetic neuralgia[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 |
333.14 |
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Formula |
C11H13BrN2O5 |
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CAS 号 |
69304-47-8 |
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中文名称 |
溴比夫定;溴夫定 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 330 mg/mL (990.57 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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