双氯蒽苯并异辛酮
基本信息
产品名称 | 双氯蒽苯并异辛酮 |
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英文名称 | Bischloroanthrabenzoxocinone |
英文别名 | BABX |
规格或纯度 | >99% |
运输条件 | 超低温冰袋运输 |
一般描述
双氯蒽苯并异辛酮((-)BABX)是II型脂肪酸合成(FASII)的选择性抑制剂。在金黄色葡萄球菌和大肠杆菌FASII分析中,BABX的IC | 50 |值分别为11.4和35.3μg/ ml,具有相当的抗菌活性。II型脂肪酸合成(FASII)对细菌细胞的生存能力至关重要,并且是开发新型抗生素的有希望的目标。最近,BABX已显示出抑制激动剂结合LXR(肝X受体)的作用。受体调节ABCA1基因的表达,该基因介导胆固醇从细胞中流出。
Bischloroanthrabenzoxocinone ((-)BABX) is a selective inhibitor of Type II fatty acid synthesis (FASII). BABX showed IC|50|values of 11.4 and 35.3 μg/ml in the S. aureus and E. coli FASII assays, respectively, with comparable antibacterial activities. Type II fatty acid synthesis (FASII) is essential to bacterial cell viability and is a promising target for the development of novel antibiotics. More recently, BABX has been shown to inhibit agonist binding LXR (Liver X receptors). The receptors regulate the expression of the ABCA1 gene, which mediates the efflux of cholesterol from cells.
相关属性
CAS编号 | 866022-28-8 |
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折光率 | n20D1.67 (Predicted) |
沸点 | ~660.1° C at 760 mmHg (Predicted) |
溶解性 | Soluble in water (limited), ethanol, methanol, DMSO, and DMF. |
储存温度 | -20°C储存 |
密度 | ~1.5 g/cm3(Predicted) |
分子量 | 543.39 |
分子式 | C28H24Cl2O7 |
品牌 | Jinpan |
Smiles | CC1=CC(=CC2=C1C3C4=C(CC(O3)(O2)C)C=C5C(=C4O)C(=O)C6=C(C5(C)C)C(=C(C(=C6O)Cl)O)Cl)OC |
PubChem CID | 11577486 |