双氯蒽苯并异辛酮
基本信息
| 产品名称 | 双氯蒽苯并异辛酮 |
|---|---|
| 英文名称 | Bischloroanthrabenzoxocinone |
| 英文别名 | BABX |
| 规格或纯度 | >99% |
| 运输条件 | 超低温冰袋运输 |
一般描述
双氯蒽苯并异辛酮（（-）BABX）是II型脂肪酸合成（FASII）的选择性抑制剂。在金黄色葡萄球菌和大肠杆菌FASII分析中，BABX的IC | 50 |值分别为11.4和35.3μg/ ml，具有相当的抗菌活性。II型脂肪酸合成（FASII）对细菌细胞的生存能力至关重要，并且是开发新型抗生素的有希望的目标。最近，BABX已显示出抑制激动剂结合LXR（肝X受体）的作用。受体调节ABCA1基因的表达，该基因介导胆固醇从细胞中流出。
Bischloroanthrabenzoxocinone ((-)BABX) is a selective inhibitor of Type II fatty acid synthesis (FASII). BABX showed IC|50|values of 11.4 and 35.3 μg/ml in the S. aureus and E. coli FASII assays, respectively, with comparable antibacterial activities. Type II fatty acid synthesis (FASII) is essential to bacterial cell viability and is a promising target for the development of novel antibiotics. More recently, BABX has been shown to inhibit agonist binding LXR (Liver X receptors). The receptors regulate the expression of the ABCA1 gene, which mediates the efflux of cholesterol from cells.
相关属性
| CAS编号 | 866022-28-8 |
|---|---|
| 折光率 | n20D1.67 (Predicted) |
| 沸点 | ~660.1° C at 760 mmHg (Predicted) |
| 溶解性 | Soluble in water (limited), ethanol, methanol, DMSO, and DMF. |
| 储存温度 | -20°C储存 |
| 密度 | ~1.5 g/cm3(Predicted) |
| 分子量 | 543.39 |
| 分子式 | C28H24Cl2O7 |
| 品牌 | Jinpan |
| Smiles | CC1=CC(=CC2=C1C3C4=C(CC(O3)(O2)C)C=C5C(=C4O)C(=O)C6=C(C5(C)C)C(=C(C(=C6O)Cl)O)Cl)OC |
| PubChem CID | 11577486 |