双氯西林钠盐一水合物

Description

Chemical structure: ß-lactamDicloxacillin is a β-lactamase resistant penicillin similar to oxacillin. Dicloxacillin hasin vitroactivity against gram-positive and gram-negative aerobic and anaerobic bacteria. It is resistant to penicillinase. It is used to study bacterial cell wall biosynthesis at the level of peptidogylcan cross-linking and to study mechanisms of penicillinase (β-lactamase) resistance. It is used to study phenylbutazone plasma binding and extracellular and intracellular killing ofStaphylococcus aureus

Description

Chemical structure: ß-lactamDicloxacillin is a β-lactamase resistant penicillin similar to oxacillin. Dicloxacillin hasin vitroactivity against gram-positive and gram-negative aerobic and anaerobic bacteria. It is resistant to penicillinase. It is used to study bacterial cell wall biosynthesis at the level of peptidogylcan cross-linking and to study mechanisms of penicillinase (β-lactamase) resistance. It is used to study phenylbutazone plasma binding and extracellular and intracellular killing ofStaphylococcus aureus

双氯蒽苯并异辛酮

双氯蒽苯并异辛酮（（-）BABX）是II型脂肪酸合成（FASII）的选择性抑制剂。在金黄色葡萄球菌和大肠杆菌FASII分析中，BABX的IC | 50 |值分别为11.4和35.3μg/ ml，具有相当的抗菌活性。II型脂肪酸合成（FASII）对细菌细胞的生存能力至关重要，并且是开发新型抗生素的有希望的目标。最近，BABX已显示出抑制激动剂结合LXR（肝X受体）的作用。受体调节ABCA1基因的表达，该基因介导胆固醇从细胞中流出。

Bischloroanthrabenzoxocinone ((-)BABX) is a selective inhibitor of Type II fatty acid synthesis (FASII). BABX showed IC|50|values of 11.4 and 35.3 μg/ml in the S. aureus and E. coli FASII assays, respectively, with comparable antibacterial activities. Type II fatty acid synthesis (FASII) is essential to bacterial cell viability and is a promising target for the development of novel antibiotics. More recently, BABX has been shown to inhibit agonist binding LXR (Liver X receptors). The receptors regulate the expression of the ABCA1 gene, which mediates the efflux of cholesterol from cells.