Aristeromycin

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Aristeromycin  纯度: 98.96%

Aristeromycin，腺苷类似物，是一种抗生素和有效的S-腺苷同型半胱氨酸水解酶 (AHCY) 抑制剂。

Aristeromycin

Aristeromycin Chemical Structure

CAS No. : 19186-33-5

规格 价格 是否有货 数量
5 mg ￥4500 In-stock
10 mg ￥8000 In-stock
25 mg ￥16500 In-stock
50 mg ￥25500 In-stock
100 mg ￥38000 In-stock
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Aristeromycin 相关产品

•相关化合物库:

  • Natural Product Library Plus
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  • Natural Product Library
  • Anti-Cancer Compound Library
  • Antibacterial Compound Library
  • Microbial Metabolite Library

生物活性

Aristeromycin, an adenosine analog, is an antibiotic and a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor[1][2].

IC50 & Target

S-adenosylhomocysteine hydrolase[1]
体外研究
(In Vitro)

The IC50 value of Aristeromycin against AHCY is 38.5 nM at 50 μM S-adenosylhomocysteine (SAH) (approximately equal to the Km: 48 μM), but 271 nM at 1000 µM SAH (20× Km). With 60 min of preincubation, the mean IC50 value of Aristeromycin at 50 μM SAH is 12.7 nM[1].
Aristeromycin has IC50 values of 3.2 μM for LNCaP-FGC cell growth and 0.88 μM for LNCaP-hr cell growth[1].
At least in part, Aristeromycin can regulate oncogenic EZH2 expression by inducing miR-26a[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

265.27

Formula

C11H15N5O3
CAS 号

19186-33-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Uchiyama N, et al. Aristeromycin and DZNeP cause growth inhibition of prostate cancer via induction of mir-26a. Eur J Pharmacol. 2017 Oct 5;812:138-146.

    [2]. Ishikura T, et al. Inhibition of S-adenosylhomocysteine hydrolase by purine nucleoside analogues. Nucleic Acids Symp Ser. 1983;(12):119-22.

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