标签归档：aristeromycin

Aristeromycin

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Aristeromycin  纯度: 98.96%

Aristeromycin，腺苷类似物，是一种抗生素和有效的S-腺苷同型半胱氨酸水解酶 (AHCY) 抑制剂。

Aristeromycin

Aristeromycin Chemical Structure

CAS No. : 19186-33-5

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5 mg ￥4500 In-stock
10 mg ￥8000 In-stock
25 mg ￥16500 In-stock
50 mg ￥25500 In-stock
100 mg ￥38000 In-stock
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Aristeromycin 相关产品

•相关化合物库:

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  • Natural Product Library
  • Anti-Cancer Compound Library
  • Antibacterial Compound Library
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生物活性

Aristeromycin, an adenosine analog, is an antibiotic and a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor[1][2].

IC50 & Target

S-adenosylhomocysteine hydrolase[1]
体外研究
(In Vitro)

The IC50 value of Aristeromycin against AHCY is 38.5 nM at 50 μM S-adenosylhomocysteine (SAH) (approximately equal to the Km: 48 μM), but 271 nM at 1000 µM SAH (20× Km). With 60 min of preincubation, the mean IC50 value of Aristeromycin at 50 μM SAH is 12.7 nM[1].
Aristeromycin has IC50 values of 3.2 μM for LNCaP-FGC cell growth and 0.88 μM for LNCaP-hr cell growth[1].
At least in part, Aristeromycin can regulate oncogenic EZH2 expression by inducing miR-26a[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

265.27

Formula

C11H15N5O3
CAS 号

19186-33-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Uchiyama N, et al. Aristeromycin and DZNeP cause growth inhibition of prostate cancer via induction of mir-26a. Eur J Pharmacol. 2017 Oct 5;812:138-146.

    [2]. Ishikura T, et al. Inhibition of S-adenosylhomocysteine hydrolase by purine nucleoside analogues. Nucleic Acids Symp Ser. 1983;(12):119-22.

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Aristeromycin

发表于由

Aristeromycin

抗菌腺苷类似物
97%

有货

Aristeromycin

CAS编号 19186-33-5 | 品牌：Jinpan
Aristeromycin

MSDS

质检证书(CoA)

相似产品

  • 分子式 C11H15N5O3
  • 分子量265.27
  • PubChem编号 65269

货号 (SKU) 包装规格 是否现货 价格 数量
A346973-5mg 5mg 期货 Aristeromycin  
A346973-10mg 10mg 期货 Aristeromycin  
A346973-25mg 25mg 期货 Aristeromycin  

基本信息

产品名称 Aristeromycin
英文名称 Aristeromycin
英文别名 (1S,2R,3R,5R)-5-(6-Amino-9H-purin-9-yl)-3-(hydroxymethyl)-1,2-cyclopentanediol; (-)-Aristeromycin; 1’a-Carbaadenosine; Aristeromycin; C-Adenosine; Carbocyclic Adenosine; Cycloadenosine; NSC 103526; [1R-(1α,2α,3β,5β)]-3-(6-Amino-9H-purin-9-yl)-5-(hydroxyme
规格或纯度 97%
运输条件 超低温冰袋运输

一般描述

Aristeromycin是具有抗菌特性的腺苷碳环类似物。

Aristeromycin is a carbocyclic analogue of adenosine that exhibits antibacterial properties.

相关属性

CAS编号 19186-33-5
储存温度 -20°C储存
分子量 265.27
分子式 C11H15N5O3
品牌 Jinpan
Smiles C1C(C(C(C1N2C=NC3=C2N=CN=C3N)O)O)CO
PubChem CID 65269