mTOR inhibitor-2 | 赛默飞Alfa aesar官网

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

mTOR inhibitor-2

mTOR inhibitor-2 是有效，选择性，可口服的 mTOR 抑制剂，IC₅₀为7 nM。mTOR Inhibitor 1抑制mTORC1 (pS6 and p4E-BP1) 和mTORC2 (pAKT (S473)) 底物的细胞磷酸化。

mTOR inhibitor-2 Chemical Structure

CAS No. : 2219323-96-1

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生物活性

mTOR inhibitor-2 is a highlt potent, selective and oral mTOR inhibitor with an IC₅₀ of 7 nM. mTOR inhibitor-2 inhibits cellular phosphorylation of mTORC1 (pS6 and p4E-BP1) and mTORC2 (pAKT (S473)) substrates^[1].

IC₅₀ & Target

mTOR

7 nM (IC₅₀)

分子量

411.46

Formula

C₂₃H₂₁N₇O

CAS 号

2219323-96-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Guo Q, et al. Highly Selective, Potent, and Oral mTOR Inhibitor for Treatment of Cancer as Autophagy Inducer. J Med Chem. 2018 Feb 8;61(3):881-904.

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