Eicosapentaenoic Acid-d5(Synonyms: EPA-d5; Timnodonic acid-d5)

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Eicosapentaenoic Acid-d5 (Synonyms: EPA-d5; Timnodonic acid-d5)

Eicosapentaenoic Acid-d5 (EPA-d5) 是 Eicosapentaenoic Acid 的氘代物。Eicosapentaenoic Acid (EPA; Timnodonic acid) 是一种 ω-3 脂肪酸。

Eicosapentaenoic Acid-d5(Synonyms: EPA-d5;  Timnodonic acid-d5)

Eicosapentaenoic Acid-d5 Chemical Structure

CAS No. : 1197205-73-4

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生物活性

Eicosapentaenoic Acid-d5 (EPA-d5) is the deuterium labeled Eicosapentaenoic Acid. Eicosapentaenoic Acid (EPA; Timnodonic acid) is an omega-3 fatty acid.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

307.48

Formula

C20H25D5O2

CAS 号

1197205-73-4

中文名称

二十碳五烯酸 d5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Martins, J.G., EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials. J Am Coll Nutr, 2009. 28(5): p. 525-42.

    [3]. Miaozhen Pan, et al. Dietary ω-3 polyunsaturated fatty acids are protective for myopia. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2104689118.

    [4]. Shun-he Wang, et al. Endogenous omega-3 long-chain fatty acid biosynthesis from alpha-linolenic acid is affected by substrate levels, gene expression, and product inhibition. RSC Adv., 2017, 7, 40946-40951.

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