3-Methyl-2-quinoxalinecarboxylic acid-d4(Synonyms: MQCA-d4)

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3-Methyl-2-quinoxalinecarboxylic acid-d4 (Synonyms: MQCA-d4)

3-Methylquinoxaline-2-carboxylic acid-d4 (MQCA-d4) 是 3-Methyl-2-quinoxalinecarboxylic acid 的氘代物。3-Methyl-2-quinoxalinecarboxylic acid (MQCA) 是 Quinocetone 或 Olaquindox 的重要 N 氧化物还原性代谢产物,可通过 S 期细胞周期停滞来有效抑制张氏肝细胞生长。

3-Methyl-2-quinoxalinecarboxylic acid-d4(Synonyms: MQCA-d4)

3-Methyl-2-quinoxalinecarboxylic acid-d4 Chemical Structure

CAS No. : 2244217-93-2

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生物活性

3-Methylquinoxaline-2-carboxylic acid-d4 (MQCA-d4) is the deuterium labeled 3-Methyl-2-quinoxalinecarboxylic acid. 3-Methyl-2-quinoxalinecarboxylic acid (MQCA), an important N-oxide reductive metabolite of Quinocetone or Olaquindox, potently inhibits the growth of Chang liver cells through S phase arrest of the cell cycle[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

192.21

Formula

C10H4D4N2O2

CAS 号

2244217-93-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Keyu Zhang , et al. Cytotoxicity and Genotoxicity of 1,4-bisdesoxyquinocetone, 3-methylquinoxaline-2-carboxylic Acid (MQCA) in Human Hepatocytes. Res Vet Sci. 2012 Dec;93(3):1393-401.

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