hDDAH-1-IN-1 TFA

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hDDAH-1-IN-1 TFA 

hDDAH-1-IN-1TFA (compound 8a) 是一种高效、选择性的非氨基酸 hDDAH-1 催化位点抑制剂,Ki 值为 18 μM。

hDDAH-1-IN-1 TFA

hDDAH-1-IN-1 TFA Chemical Structure

CAS No. : 1229238-70-3

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生物活性

hDDAH-1-IN-1 TFA (compound 8a) is a potent and selective non-amino acid catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), with a Ki of 18 µM[1].

体外研究
(In Vitro)

hDDAH-1-IN-1 TFA potently inhibits hDDAH-1 (Ki = 18 µM) without significantly affecting NOSs and arginase[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

416.32

Formula

C12H22F6N4O5

CAS 号

1229238-70-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Lunk I, et al. Discovery of N-(4-Aminobutyl)-N’-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1). J Med Chem. 2019 Dec 31.

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