Esculentoside H (EsH) 是从多年生植物 Phytolacca esculent 的根提取物中分离的一种皂苷。 Esculentoside H (EH) 具有抗肿瘤活性,其机制与 TNF 释放能力有关。 Esculentoside H (EsH) 通过阻断 JNK1/2 和 NF-κB 信号介导的基质金属蛋白酶-9 (MMP-9) 表达抑制结肠癌细胞迁移。
Esculentoside H Chemical Structure
CAS No. : 66656-92-6
规格
价格
是否有货
数量
5 mg
¥1500
In-stock
10 mg
¥2500
In-stock
50 mg
询价
100 mg
询价
* Please select Quantity before adding items.
Esculentoside H 相关产品
•相关化合物库:
Natural Product Library Plus
Bioactive Compound Library Plus
Immunology/Inflammation Compound Library
Kinase Inhibitor Library
MAPK Compound Library
NF-κB Signaling Compound Library
Stem Cell Signaling Compound Library
Natural Product Library
Anti-Cancer Compound Library
Anti-Aging Compound Library
Antioxidants Compound Library
Differentiation Inducing Compound Library
Reprogramming Compound Library
Glycoside Compound Library
Oxygen Sensing Compound Library
Terpenoids Library
Pyroptosis Compound Library
Traditional Chinese Medicine Monomer Library
Anti-Breast Cancer Compound Library
Anti-Pancreatic Cancer Compound Library
Anti-Blood Cancer Compound Library
Anti-Parkinson’s Disease Compound Library
Anti-Obesity Compound Library
Transcription Factor Targeted Library
Food-Sourced Compound Library
Anti-Liver Cancer Compound Library
Anti-Colorectal Cancer Compound Library
生物活性
Esculentoside H (EsH) is a saponin isolated from the root extract of perennial plant Phytolacca esculenta[1]. Esculentoside H (EH) has anti-tumor activity, the mechanism is related to the capacity for TNFrelease[2]. Esculentoside H (EsH) suppresses colon cancer cell migration through blockage of the JNK1/2 and NF-κB signaling-mediated matrix metalloproteinases-9 (MMP-9) expression[1].
Clinical Trial
分子量
989.10
Formula
C48H76O21
CAS 号
66656-92-6
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Ha SH, et al. Esculentoside H inhibits colon cancer cell migration and growth through suppression of MMP-9 gene expression via NF-kB signaling pathway. J Cell Biochem. 2019 Jun;120(6):9810-9819.
[2]. Hu ZL, et al. Effect of esculentoside H on release of tumor necrosis factor from mouse peritoneal macrophages. Zhongguo Yao Li Xue Bao. 1993 Nov;14(6):550-2.