DBCO-Sulfo-NHS ester sodium

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

DBCO-Sulfo-NHS ester sodium 

DBCO-Sulfo-NHS ester sodium 是一种可降解 (cleavable) 的 ADC linker,用于抗体偶联药物 (ADCs) 的合成。

DBCO-Sulfo-NHS ester sodium

DBCO-Sulfo-NHS ester sodium Chemical Structure

CAS No. : 1400191-52-7

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

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生物活性

DBCO-Sulfo-NHS ester sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

532.50

Formula

C25H21N2NaO8S

CAS 号

1400191-52-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jung S, et al. Facile strategy for protein conjugation with chitosan-poly(ethylene glycol) hybrid microparticleplatforms via strain-promoted alkyne-azide cycloaddition (SPAAC) reaction. Biomacromolecules. 2013 Nov 11;14(11):3892-902.

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DBCO-PEG5-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

DBCO-PEG5-NHS ester 

DBCO-PEG5-NHS ester 是一种 PROTAC 连接桥,属于 PEG 类和 Alkyl/ether 类,用于合成一系列 PROTAC 分子。DBCO-PEG5-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。

DBCO-PEG5-NHS ester

DBCO-PEG5-NHS ester Chemical Structure

CAS No. : 2144395-59-3

规格 是否有货
25 mg 询价
50 mg 询价
100 mg 询价

* Please select Quantity before adding items.

生物活性

DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1][2].

IC50 & Target[1][2]

Cleavable

 

Alkyl/ether

 

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

693.74

Formula

C36H43N3O11

CAS 号

2144395-59-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Craig L. Duvall, et al. Conjugation of lipophilic albumin-binding moiety to rna for improved carrier-free in vivo pharmacokinetics and gene silencing. US20180064749A1.

    [2]. Samantha M Sarett, et al. Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing. Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6490-E6497.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

m-PEG9-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

m-PEG9-NHS ester 

m-PEG9-NHS ester 是一种基于 PEG 的 PROTAC linker,用于 PROTAC 合成。

m-PEG9-NHS ester

m-PEG9-NHS ester Chemical Structure

CAS No. : 1316189-13-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

m-PEG9-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

IC50 & Target[1]

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

553.60

Formula

C24H43NO13

CAS 号

1316189-13-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Alexander Chucholowski, et al. Cyclodextrin conjugates. WO2010017328A2.

    [2]. Satwik Kamtekar, et al. Modified biotin-binding proteins for immobilization. WO2019126734A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Propargyl-PEG3-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Propargyl-PEG3-NHS ester 

Propargyl-PEG3-NHS ester 是一种 PROTAC 连接桥,属于 PEG 类和 Alkyl/ether 类。Propargyl-PEG3-NHS ester 可用于合成一系列 PROTAC 分子。Propargyl-PEG3-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。

Propargyl-PEG3-NHS ester

Propargyl-PEG3-NHS ester Chemical Structure

CAS No. : 1428629-71-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Propargyl-PEG3-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG3-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable

 

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

313.30

Formula

C14H19NO7

CAS 号

1428629-71-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. US20170252458A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Propargyl-PEG8-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Propargyl-PEG8-NHS ester 

Propargyl-PEG8-NHS ester 是一种 PROTAC 连接桥,属于 PEG 类和 Alkyl/ether 类。Propargyl-PEG8-NHS ester 可用于合成一系列 PROTAC 分子。Propargyl-PEG8-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。

Propargyl-PEG8-NHS ester

Propargyl-PEG8-NHS ester Chemical Structure

CAS No. : 2182601-74-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Propargyl-PEG8-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable

 

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

533.57

Formula

C24H39NO12

CAS 号

2182601-74-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Satwik Kamtekar, et al. Modified biotin-binding proteins for immobilization. WO2019126734A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Propargyl-PEG7-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Propargyl-PEG7-NHS ester 

Propargyl-PEG7-NHS ester 是一种 PROTAC 连接桥,属于 PEG 类和 Alkyl/ether 类。Propargyl-PEG7-NHS ester 可用于合成一系列 PROTAC 分子。Propargyl-PEG7-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。

Propargyl-PEG7-NHS ester

Propargyl-PEG7-NHS ester Chemical Structure

CAS No. : 2093152-77-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Propargyl-PEG7-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG7-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable

 

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

489.51

Formula

C22H35NO11

CAS 号

2093152-77-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. US20170252458A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Propargyl-PEG6-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Propargyl-PEG6-NHS ester 

Propargyl-PEG6-NHS ester 是一种 PROTAC 连接桥,属于 PEG 类和 Alkyl/ether 类。Propargyl-PEG6-NHS ester 可用于合成一系列 PROTAC 分子。Propargyl-PEG6-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。

Propargyl-PEG6-NHS ester

Propargyl-PEG6-NHS ester Chemical Structure

CAS No. : 2093153-99-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Propargyl-PEG6-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable

 

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

445.46

Formula

C20H31NO10

CAS 号

2093153-99-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Anandan Palani, et al. Insulin-incretin conjugates. WO2017160669A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Mal-PEG8-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Mal-PEG8-NHS ester 

Mal-PEG8-acid 是一种基于 PEG 结构的 PROTAC linker,可用于 PROTAC 的合成。

Mal-PEG8-NHS ester

Mal-PEG8-NHS ester Chemical Structure

CAS No. : 2055033-05-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Mal-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

IC50 & Target[1]

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

618.63

Formula

C27H42N2O14

CAS 号

2055033-05-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Mal-PEG5-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Mal-PEG5-NHS ester 

Mal-PEG5-NHS ester 是一种基于 PEG 和 Alkyl/ether 的 PROTAC linker,可用于 PROTAC 的合成。

Mal-PEG5-NHS ester

Mal-PEG5-NHS ester Chemical Structure

CAS No. : 1807537-42-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Mal-PEG5-NHS ester is an Alkyl/ether and PEG-based PROTAC linker can be used in the synthesis of PROTACs.

IC50 & Target

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

486.47

Formula

C21H30N2O11

CAS 号

1807537-42-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

m-PEG7-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

m-PEG7-NHS ester 

m-PEG7-NHS ester 是一种基于PEG 的 PROTAC linker,可用于 PROTAC 的合成。

m-PEG7-NHS ester

m-PEG7-NHS ester Chemical Structure

CAS No. : 874208-92-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

m-PEG7-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

465.49

Formula

C20H35NO11

CAS 号

874208-92-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

m-PEG4-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

m-PEG4-NHS ester 

m-PEG4-NHS ester 是一种基于PEG 的 PROTAC linker,可用于 PROTAC 的合成。

m-PEG4-NHS ester

m-PEG4-NHS ester Chemical Structure

CAS No. : 622405-78-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

m-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

333.33

Formula

C14H23NO8

CAS 号

622405-78-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

m-PEG3-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

m-PEG3-NHS ester 

m-PEG3-NHS ester 是一种基于PEG 的 PROTAC linker,可用于 PROTAC 的合成。

m-PEG3-NHS ester

m-PEG3-NHS ester Chemical Structure

CAS No. : 876746-59-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

m-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

289.28

Formula

C12H19NO7

CAS 号

876746-59-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

m-PEG5-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

m-PEG5-NHS ester 

m-PEG5-NHS ester 是一种基于PEG 的 PROTAC linker,可用于 PROTAC 的合成。

m-PEG5-NHS ester

m-PEG5-NHS ester Chemical Structure

CAS No. : 874208-94-3

规格 价格 是否有货
250 mg ¥1700 询问价格 & 货期
500 mg ¥2850 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

m-PEG5-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

377.39

Formula

C16H27NO9

CAS 号

874208-94-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

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m-PEG6-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

m-PEG6-NHS ester 

m-PEG6-NHS ester 是一种不可降解 (non-cleavable) 的含 6 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。m-PEG6-NHS ester 是一种 PROTAC linker,属于 PEG/Alkyl/ether 类,可用于合成 PROTAC 分子。

m-PEG6-NHS ester

m-PEG6-NHS ester Chemical Structure

CAS No. : 1449390-12-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

m-PEG6-NHS ester is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG6-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

IC50 & Target

PEGs

 

Alkyl/ether

 

Non-cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

421.44

Formula

C18H31NO10

CAS 号

1449390-12-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

m-PEG8-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

m-PEG8-NHS ester 

m-PEG8-NHS ester 是一种不可降解 (non-cleavable) 的含 8 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

m-PEG8-NHS ester

m-PEG8-NHS ester Chemical Structure

CAS No. : 756525-90-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

m-PEG8-NHS ester is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

509.54

Formula

C22H39NO12

CAS 号

756525-90-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. By Boehnke, et al. Preparation of antibody drug conjugates with NAMPT inhibitors for use in treatment of cancer. Patent WO2019149637A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Biotin-PEG3-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Biotin-PEG3-NHS ester 

Biotin-PEG3-NHS ester 是基于 PEG 结构的 PROTAC linker, 可以用来制备 PROTAC。

Biotin-PEG3-NHS ester

Biotin-PEG3-NHS ester Chemical Structure

CAS No. : 1253286-56-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Biotin-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

544.62

Formula

C23H36N4O9S

CAS 号

1253286-56-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Mal-PEG24-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Mal-PEG24-NHS ester 

Mal-PEG24-NHS ester 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Mal-PEG24-NHS ester

Mal-PEG24-NHS ester Chemical Structure

CAS No. : 2226733-37-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Mal-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

381.34

Formula

C18H23N3O9

CAS 号

2226733-37-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Bis-PEG5-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Bis-PEG5-NHS ester 

Bis-PEG5-NHS ester 是一种 PROTAC 连接桥,属于 PEG 类和 Alkyl/ether 类。Bis-PEG5-NHS ester 可用于合成一系列 PROTAC 分子。Bis-PEG5-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。

Bis-PEG5-NHS ester

Bis-PEG5-NHS ester Chemical Structure

CAS No. : 756526-03-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Bis-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable

 

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

532.50

Formula

C22H32N2O13

CAS 号

756526-03-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Hans-Georg Lerchen, et al. Prodrugs of cytotoxic active agents having enzymatically cleavable groups. WO2018114798A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Bis-PEG10-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Bis-PEG10-NHS ester 

Bis-PEG10-NHS ester 是一种 PROTAC 连接桥,属于 PEG 类和 Alkyl/ether 类。Bis-PEG10-NHS ester 可用于合成一系列 PROTAC 分子。Bis-PEG10-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。

Bis-PEG10-NHS ester

Bis-PEG10-NHS ester Chemical Structure

CAS No. : 2221949-02-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Bis-PEG10-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG10-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

PEGs

 

Alkyl/ether

 

Cleavable

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

752.76

Formula

C32H52N2O18

CAS 号

2221949-02-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. John L. Magnani, et al. Highly potent multimeric e-selectin antagonists. WO2018068010A1

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Bis-PEG13-NHS ester

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Bis-PEG13-NHS ester 

Bis-PEG13-NHS ester 是一种 PROTAC 连接桥,属于 PEG 类和 Alkyl/ether 类。Bis-PEG13-NHS ester 可用于合成一系列 PROTAC 分子。Bis-PEG13-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。

Bis-PEG13-NHS ester

Bis-PEG13-NHS ester Chemical Structure

CAS No. : 2221949-00-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Bis-PEG13-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG13-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

PEGs

 

Alkyl/ether

 

Cleavable

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

884.92

Formula

C38H64N2O21

CAS 号

2221949-00-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. John L. Magnani, et al. Highly potent multimeric e-selectin antagonists. WO2018068010A1

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务