核丛青霉素
主要从青霉属物种中分离出来的天然产物
有货
基本信息
| 产品名称 | 核丛青霉素 |
|---|---|
| 英文名称 | Sclerotiorin |
| 英文别名 | (S-(R*,R*-(E,E)))-Sclerotiorin |
| 运输条件 | 超低温冰袋运输 |
一般描述
核丛青霉素是主要从青霉属中分离的天然产物。它以4.2μM的IC |值抑制大豆脂氧合酶-1。硬化蛋白还表现出许多其他活性，包括抑制CETP（胆固醇酯转移蛋白，IC | 50 | = 19.4μM），抑制Grb2-Shc相互作用（IC | 50 | = 22μM）以及对ETAR和ETBR的拮抗作用（内皮细胞受体），其对于人细胞的IC | 50 | = 114和152μM。
Sclerotiorin is a natural product isolated primarily from|Penicillium|species. It inhibits soybean lipoxygenase-1 with an IC|50|value of 4.2 μM. Sclerotiorin also exhibits a number of other activities encompassing inhibition of CETP (cholesterol ester transfer protein, IC|50|= 19.4 μM), inhibition of Grb2-Shc interaction (IC|50|= 22 μM), and antagonism of ETAR and ETBR (endothelin receptors) with respective IC|50|= 114 and 152 μM for human cells.
相关属性
| CAS编号 | 549-23-5 |
|---|---|
| 折光率 | n20D1.56 (Predicted) |
| 熔点 | 199.90° C (Predicted) |
| 沸点 | ~482.9° C at 760 mmHg (Predicted) |
| 溶解性 | Soluble in ethanol (~3 mg/ml), DMSO (~20 mg/ml), DMF (~30 mg/ml), and 1: 2 solution of DMF: PBS (pH 7.2) (~0.3 mg/ml). |
| 储存温度 | -20°C储存 |
| 密度 | ~1.2 g/cm3(Predicted) |
| 分子量 | 390.86 |
| 分子式 | C₂₁H₂₃ClO₅ |
| 品牌 | Jinpan |
| Smiles | CC[C@H](C)/C=C(\\C)/C=C/C1=CC2=C(C(=O)[C@H](C(=O)C2=CO1)(C)OC(=O)C)Cl |
| IC50 | Soybean lipoxygenase-1: IC₅₀= 4.2 μM; Cholesterol ester transfer protein : IC₅₀= 19.4 μM; Grb2-Shc interaction : IC₅₀= 22 μM; ETAR: IC₅₀= 114 μM (human); ETBR: IC₅₀= 152 μM (human) |
| PubChem CID | 6436015 |