标签归档：goserelin

多肽定制Goserelin 编码 [145781-92-6]

发表于由

上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

名称 Goserelin
编码 [145781-92-6]
别名 Goserelin
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） Pyr-HWSYs(tBu)-LRP-Azagly-NH2
序列（三字母缩写） Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2?(acetate salt)
基本描述 Goserelin acetate, a synthetic peptide analog of LHRH, is used in the treatment of prostate cancer, advanced breast cancer and in the management of endometriosis.
溶解度
分子量 1269.43
化学式 C59H84N18O14
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Goserelin 编码 [145781-92-6]
Figures Goserelin 编码 [145781-92-6]
Reference A.Wells et al., Clin. Cancer Res., 8, 1251 (2002) A.Rody et al., Expert Rev. Anticancer Ther., 5, 591 (2005) H.Lepor, Rev. Urol., 7 (Suppl. 5), S3 (2005) Merck Index, 14th ed., No. 4526, (2006) M.Roach 3rd and A.Izaguirre, Expert Opin. Pharmacother., 8, 257 (2007) R.M.Herrmann et al., Rad. Oncol., 2, 31 (2007)
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化学桥

多肽定制Goserelin (free base) 编码 [65807-02-5]

发表于由

上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

名称 Goserelin (free base)
编码 [65807-02-5]
别名 Goserelin (free base)
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） Pyr-HWSYs(tBu)-LRP-Azagly-NH2
序列（三字母缩写） Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2?(trifluoroacetate salt)
基本描述 The GnRH II sequence pEHWSHGWYPG amide, first detected in chicken, is highly conserved in vertebrates.
溶解度
分子量 1269.43
化学式 C59H84N18O14
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Goserelin (free base) 编码 [65807-02-5]
Figures Goserelin (free base) 编码 [65807-02-5]
Reference A.Wells et al., Clin. Cancer Res., 8, 1251 (2002) A.Rody et al., Expert Rev. Anticancer Ther., 5, 591 (2005) H.Lepor, Rev. Urol., 7 (Suppl. 5), S3 (2005) Merck Index, 14th ed., No. 4526, (2006) M.Roach 3rd and A.Izaguirre, Expert Opin. Pharmacother., 8, 257 (2007) R.M.Herrmann et al., Rad. Oncol., 2, 31 (2007)
C端
N端
化学桥

多肽定制Goserelin Acetate 编码 [145781-92-6]

发表于由

上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

名称 Goserelin Acetate
编码 [145781-92-6]
别名 Goserelin Acetate
纯度 80%，90%，95%，98%，99%
重量 1mg,5mg,10mg,50mg,100mg,1g
序列（单字母缩写） PYRHWSYs(tBu)LRPAZAG-NH2
序列（三字母缩写） Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-AzaGly-NH2
基本描述
溶解度
分子量 1269.4
化学式 C59H84N18O14
存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
注释
Documents Goserelin Acetate 编码 [145781-92-6]
Figures Goserelin Acetate 编码 [145781-92-6]
Reference
C端
N端
化学桥

Goserelin acetate(Synonyms: 醋酸戈舍瑞林; ICI-118630 acetate)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Goserelin acetate (Synonyms: 醋酸戈舍瑞林; ICI-118630 acetate) 纯度: 99.23%

Goserelin acetate (ICI-118630 acetate) 是一种促性腺激素释放激素 (GnRH/LHRH) 十肽类似物，能作为 GnRH 激动剂。Goserelin acetate 可用于乳腺癌、上皮性卵巢癌和前列腺癌的研究。

Goserelin acetate(Synonyms: 醋酸戈舍瑞林; ICI-118630 acetate)

Goserelin acetate Chemical Structure

CAS No. : 145781-92-6

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1930 In-stock
5 mg ￥910 In-stock
10 mg ￥1320 In-stock
50 mg ￥4620 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Goserelin acetate 相关产品

•相关化合物库:

  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • FDA-Approved Drug Library Mini
  • Bioactive Compound Library Plus
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  • FDA-Approved Drug Library
  • Anti-Cancer Compound Library
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  • FDA Approved & Pharmacopeial Drug Library
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  • Targeted Diversity Library
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  • Peptide Library

生物活性

Goserelin acetate (ICI-118630 acetate), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin acetate can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer[1][2].

IC50 & Target

GnRH[1]
体外研究
(In Vitro)

Goserelin (1 nM-1 mM; 48-72 hours) promotes EOC cell apoptosis[1].
Goserelin (100 μM; 24-72 hours) regulates the expression of human apoptosis-related genes in SKOV3-ip cells[1].
Goserelin (100 μM; 24-72 hours) promotes EOC cell apoptosis by upregulating FOXO1 through the PI3K/AKT signaling pathway[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines)
Concentration: 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 100 μM, 1 mM
Incubation Time: 48 hours, 72 hours
Result: Significantly increased the total apoptosis rate of SKOV3-ip, SKOV3 and A2780 cells.

Western Blot Analysis[1]

Cell Line: SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines)
Concentration: 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 100 μM, 1 mM
Incubation Time: 48 hours, 72 hours
Result: The expression of cleaved-caspase-3 and cleaved-PARP were observably increased at 100 μM.

RT-PCR[1]

Cell Line: SKOV3-ip cells
Concentration: 100 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Expression of human apoptosis-related genes regulated

体内研究
(In Vivo)

Goserelin (100 µg; s.c.; daily; for 19 days) significantly increases the proportion of apoptotic cells in the subcutaneous xenograft tumors[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-week-old specific-pathogen free (SPF) female nude mice (18-20 g), subcutaneous xenograft tumor model[1]
Dosage: 100 µg/mice
Administration: Subcutaneous injection, daily, for 19 days
Result: Significantly increased the proportion of apoptotic cells in the subcutaneous xenograft tumors

Clinical Trial

分子量

1329.46

Formula

C61H88N18O16
CAS 号

145781-92-6
中文名称

醋酸戈舍瑞林
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : 100 mg/mL (75.22 mM; Need ultrasonic)

DMSO : ≥ 28 mg/mL (21.06 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.7522 mL 3.7609 mL 7.5219 mL
5 mM 0.1504 mL 0.7522 mL 1.5044 mL
10 mM 0.0752 mL 0.3761 mL 0.7522 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (1.56 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (1.56 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (1.56 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (1.56 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: 2.08 mg/mL (1.56 mM); Clear solution; Need warming

    此方案可获得 2.08 mg/mL (1.56 mM) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Ning Zhang, et al. Goserelin promotes the apoptosis of epithelial ovarian cancer cells by upregulating forkhead box O1 through the PI3K/AKT signaling pathway. Oncol Rep. 2018 Mar; 39(3): 1034–1042.

    [2]. Halle C F Moore, et al. Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy. N Engl J Med. 2015 Mar 5;372(10):923-32.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Goserelin(Synonyms: 戈舍瑞林; ICI 118630)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Goserelin (Synonyms: 戈舍瑞林; ICI 118630)

Goserelin (ICI 118630) 是一种促性腺激素释放激素 (GnRH/LHRH) 十肽类似物，能作为 GnRH 激动剂。Goserelin 可用于乳腺癌、上皮性卵巢癌和前列腺癌的研究。

Goserelin(Synonyms: 戈舍瑞林; ICI 118630)

Goserelin Chemical Structure

CAS No. : 65807-02-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Goserelin 的其他形式现货产品:

Goserelin acetate

生物活性

Goserelin (ICI 118630), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer[1][2].

IC50 & Target

GnRH[1]
体外研究
(In Vitro)

Goserelin (1 nM-1 mM; 48-72 hours) promots EOC cell apoptosis[1].
Goserelin (100 μM; 24-72 hours) regulates the expression of human apoptosis-related genes in SKOV3-ip cells[1].
Goserelin (100 μM; 24-72 hours) influences EOC cell apoptosis by upregulating FOXO1 through the PI3K/AKT signaling pathway[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines)
Concentration: 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 100 μM, 1 mM
Incubation Time: 48 hours, 72 hours
Result: Significantly increased the total apoptosis rate of SKOV3-ip, SKOV3 and A2780 cells.

Western Blot Analysis[1]

Cell Line: SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines)
Concentration: 1 nM, 10 nM, 100 nM, 1μM , 10 μM, 100 μM, 1 mM
Incubation Time: 48 hours, 72 hours
Result: The expression of cleaved-caspase-3 and cleaved-PARP were observably increased at 100 μM.

RT-PCR[1]

Cell Line: SKOV3-ip cells
Concentration: 100 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Expression of human apoptosis-related genes regulated

体内研究
(In Vivo)

Goserelin (100 µg; s.c.; daily; for 19 days) significantly increases the proportion of apoptotic cells in the subcutaneous xenograft tumors[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-week-old specific-pathogen free (SPF) female nude mice (18-20 g), subcutaneous xenograft tumor model[1]
Dosage: 100 µg/mice
Administration: Subcutaneous injection, daily, for 19 days
Result: Significantly increased the proportion of apoptotic cells in the subcutaneous xenograft tumors

Clinical Trial

分子量

1269.41

Formula

C59H84N18O14
CAS 号

65807-02-5
中文名称

戈舍瑞林
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ning Zhang, et al. Goserelin promotes the apoptosis of epithelial ovarian cancer cells by upregulating forkhead box O1 through the PI3K/AKT signaling pathway. Oncol Rep. 2018 Mar; 39(3): 1034–1042.

    [2]. Halle C F Moore, et al. Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy. N Engl J Med. 2015 Mar 5;372(10):923-32.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务