标签归档：vcp

Mal-PEG2-VCP-NB

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Mal-PEG2-VCP-NB 

Mal-PEG2-VCP-NB 是一种可降解的 ADC linker，含有 Maleimide 基团，2 单元 PEG 和 VCP NB。

Mal-PEG2-VCP-NB

Mal-PEG2-VCP-NB Chemical Structure

CAS No. : 2395887-69-9

规格 价格 是否有货 数量
100 mg ￥6900 In-stock
500 mg ￥13790 In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

生物活性

Mal-PEG2-VCP-NB is a claevable ADC linker containing a Maleimide group, 2-unit PEG and a VCP NB.

IC50 & Target

Cleavable

 

分子量

783.78

Formula

C36H45N7O13
CAS 号

2395887-69-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶解性数据
In Vitro: 

DMSO : 100 mg/mL (127.59 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2759 mL 6.3793 mL 12.7587 mL
5 mM 0.2552 mL 1.2759 mL 2.5517 mL
10 mM 0.1276 mL 0.6379 mL 1.2759 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.67 mg/mL (3.41 mM); Clear solution

    此方案可获得 ≥ 2.67 mg/mL (3.41 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 26.7 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.67 mg/mL (3.41 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.67 mg/mL (3.41 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例，取 100 μL 26.7 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.67 mg/mL (3.41 mM); Clear solution

    此方案可获得 ≥ 2.67 mg/mL (3.41 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 26.7 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

VCP/p97 inhibitor-1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

VCP/p97 inhibitor-1 

VCP/p97 inhibitor-1 是一种有效的 VCP/p97 (也称为 Cdc48，CDC-. 48，或 Ter94) 抑制剂，IC50 值为 54.7 nM。VCP/p97 inhibitor-1 导致蛋白质稳态失调并干扰泛素-蛋白酶体系统 (UPS) 对错误折叠多肽的降解。

VCP/p97 inhibitor-1

VCP/p97 inhibitor-1 Chemical Structure

CAS No. : 2630950-38-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS)[1][2].

IC50 & Target

54.7 nM (VCP/p97)[1]
体外研究
(In Vitro)

VCP/p97 inhibitor-1 (compound 17) (3-fold serial dilutions with the highest concentration at 10 μM; 72 hours) has anti-proliferation effect with IC50s of 2.9 and 0.86 μM in A549 and RPMI8226 cells, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: A549, RPMI8226 cells
Concentration: 3-fold serial dilutions with the highest concentration at 10 μM
Incubation Time: 72 hours
Result: Showed anti-proliferative rates in A549 and RPMI8226 cells (IC50= 2.9 and 0.86 μM, respectively).

分子量

491.37

Formula

C24H26BN5O4S
CAS 号

2630950-38-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang Y, et al. Discovery of novel pyrimidine molecules containing boronic acid as VCP/p97 Inhibitors. Bioorg Med Chem. 2021;38:116114.

    [2]. van den Boom J, et al. VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. Mol Cell. 2018;69(2):182-194.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

VCP/p97 inhibitor-1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

VCP/p97 inhibitor-1 

VCP/p97 inhibitor-1 是一种有效的 VCP/p97 (也称为 Cdc48，CDC-. 48，或 Ter94) 抑制剂，IC50 值为 54.7 nM。VCP/p97 inhibitor-1 导致蛋白质稳态失调并干扰泛素-蛋白酶体系统 (UPS) 对错误折叠多肽的降解。

VCP/p97 inhibitor-1

VCP/p97 inhibitor-1 Chemical Structure

CAS No. : 2630950-38-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS)[1][2].

IC50 & Target

54.7 nM (VCP/p97)[1]
体外研究
(In Vitro)

VCP/p97 inhibitor-1 (compound 17) (3-fold serial dilutions with the highest concentration at 10 μM; 72 hours) has anti-proliferation effect with IC50s of 2.9 and 0.86 μM in A549 and RPMI8226 cells, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: A549, RPMI8226 cells
Concentration: 3-fold serial dilutions with the highest concentration at 10 μM
Incubation Time: 72 hours
Result: Showed anti-proliferative rates in A549 and RPMI8226 cells (IC50= 2.9 and 0.86 μM, respectively).

分子量

491.37

Formula

C24H26BN5O4S
CAS 号

2630950-38-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang Y, et al. Discovery of novel pyrimidine molecules containing boronic acid as VCP/p97 Inhibitors. Bioorg Med Chem. 2021;38:116114.

    [2]. van den Boom J, et al. VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. Mol Cell. 2018;69(2):182-194.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

VCP/p97 inhibitor-1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

VCP/p97 inhibitor-1 

VCP/p97 inhibitor-1 是一种有效的 VCP/p97 (也称为 Cdc48，CDC-. 48，或 Ter94) 抑制剂，IC50 值为 54.7 nM。VCP/p97 inhibitor-1 导致蛋白质稳态失调并干扰泛素-蛋白酶体系统 (UPS) 对错误折叠多肽的降解。

VCP/p97 inhibitor-1

VCP/p97 inhibitor-1 Chemical Structure

CAS No. : 2630950-38-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS)[1][2].

IC50 & Target

54.7 nM (VCP/p97)[1]
体外研究
(In Vitro)

VCP/p97 inhibitor-1 (compound 17) (3-fold serial dilutions with the highest concentration at 10 μM; 72 hours) has anti-proliferation effect with IC50s of 2.9 and 0.86 μM in A549 and RPMI8226 cells, respectively[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: A549, RPMI8226 cells
Concentration: 3-fold serial dilutions with the highest concentration at 10 μM
Incubation Time: 72 hours
Result: Showed anti-proliferative rates in A549 and RPMI8226 cells (IC50= 2.9 and 0.86 μM, respectively).

分子量

491.37

Formula

C24H26BN5O4S
CAS 号

2630950-38-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang Y, et al. Discovery of novel pyrimidine molecules containing boronic acid as VCP/p97 Inhibitors. Bioorg Med Chem. 2021;38:116114.

    [2]. van den Boom J, et al. VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. Mol Cell. 2018;69(2):182-194.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

VCP-Eribulin

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

VCP-Eribulin 

VCP-Eribulin 由 ADC linker (VCP) 和 Eribulin 偶联而成。Eribulin 是一种独特的微管 (microtubule) 抑制剂，具有抗肿瘤活性。VCP-Eribulin 可用于偶联抗体。

VCP-Eribulin

VCP-Eribulin Chemical Structure

CAS No. : 2130869-17-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

VCP-Eribulin consists the ADCs linker (VCP) and Eribulin[1]. Eribulin is a mechanistically unique microtubule inhibitor for cancer[2]. VCP-Eribulin is an Eribulin-based drug for antibody conjugates[1].

IC50 & Target

Traditional Cytotoxic Agents

 

分子量

1135.34

Formula

C59H86N6O16
CAS 号

2130869-17-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. US20170252458A1.

    [2]. Towle MJ, et al. Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res. 2011 Jan 15;71(2):496-505.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务