日度归档：2024年4月27日

TCS-OX2-29 hydrochloride(Synonyms: OX2R antagonist)

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TCS-OX2-29 hydrochloride (Synonyms: OX2R antagonist)

TCS-OX2-29 (hydrochloride) 是一种有效的，高亲和力和选择性的 OX2R 拮抗剂，其 IC50 值为 40 nM，pKI 值为 7.5。与 OX1 相比，TCS-OX2-29 对 OX2 的选择性约高了 250倍。

TCS-OX2-29 hydrochloride(Synonyms: OX2R antagonist)

TCS-OX2-29 hydrochloride Chemical Structure

CAS No. : 1610882-30-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

TCS-OX2-29 hydrochloride 的其他形式现货产品:

TCS-OX2-29

生物活性

TCS-OX2-29 (hydrochloride) is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1[1][2].

分子量

433.97

Formula

C23H32ClN3O3
CAS 号

1610882-30-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hirose M, et al. N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4497-9.

    [2]. Tabaeizadeh M, et al. The differential effects of OX1R and OX2R selective antagonists on morphine conditioned place preference in naïve versus morphine-dependent mice. Behav Brain Res. 2013 Jan 15;237:41-8.

    [3]. Mould R, et al. Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. Br J Pharmacol. 2014 Jan;171(2):351-63.

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SR0987

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SR0987  纯度: 99.54%

SR0987是SR1078 的一个类似物，是 RORγt 的一个激动剂，其 EC50 值为800 nM。SR0987 可上调IL17 的表达且抑制PD-1 的表达。

SR0987

SR0987 Chemical Structure

CAS No. : 303126-97-8

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥968 In-stock
5 mg ￥880 In-stock
10 mg ￥1540 In-stock
25 mg ￥3190 In-stock
50 mg ￥5390 In-stock
100 mg ￥9680 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

SR0987 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Metabolism/Protease Compound Library
  • Anti-Cancer Compound Library
  • Small Molecule Immuno-Oncology Compound Library
  • Transcription Factor Targeted Library

生物活性

SR0987, a SR1078 analog, is a RORγt agonist, with an EC50 of 800 nM. SR0987 increases IL17 expression while repressing the expression of PD-1[1].

IC50 & Target

EC50: 800 nM (RORγt)[1].
体外研究
(In Vitro)

SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC50 of ~800nM. SR0987 treatment results in a statistically significant reduction of the surface expression of PD-1 whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trend towards increased IL17 production[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

397.70

Formula

C16H10ClF6NO2
CAS 号

303126-97-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 150 mg/mL (377.17 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5145 mL 12.5723 mL 25.1446 mL
5 mM 0.5029 mL 2.5145 mL 5.0289 mL
10 mM 0.2514 mL 1.2572 mL 2.5145 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.29 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.29 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.29 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.29 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.29 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.29 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Chang MR, et al. Synthetic RORγt Agonists Enhance Protective Immunity. ACS Chem Biol. 2016 Apr 15;11(4):1012-8.

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NK-252

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NK-252  纯度: 99.93%

NK-252 是一种潜在的 Nrf2 激活剂，具有很好的 Nrf2 活化能力。

NK-252

NK-252 Chemical Structure

CAS No. : 1414963-82-8

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥726 In-stock
5 mg ￥660 In-stock
10 mg ￥1100 In-stock
25 mg ￥2300 In-stock
50 mg ￥4000 In-stock
100 mg ￥6900 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

NK-252 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • NF-κB Signaling Compound Library
  • Stem Cell Signaling Compound Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Antioxidants Compound Library
  • Oxygen Sensing Compound Library
  • Ferroptosis Compound Library
  • Transcription Factor Targeted Library

生物活性

NK-252 is a potential Nrf2 activator, which exhibits a great Nrf2-activating potential.

IC50 & Target

Nrf2[1]
体外研究
(In Vitro)

The luciferase activity in Huh-7.5 cells treated with Oltipraz (OPZ) or NK-252 shows activation of the NAD(P)H quinone oxidoreductase 1 (NQO1)-ARE in a dose-dependent manner. NK-252 displays this effect with higher potency than OPZ based on the fact that the EC2 value (concentration for a 2-fold induction above background), calculated with linear extrapolation from the values above and below the induction threshold, is 20.8 μM for OPZ and 1.36 μM for NK-252. NK-252 has potential as an Nrf2 activator in hepatic cells. Prototypical Nrf2 activators that include OPZ have been reported to protect microglial cells from H2O2-induced cytotoxicity. The protective effects of OPZ and NK-252 are examined against H2O2-induced cytotoxicity using Huh-7 cells to evaluate their antioxidant properties. The cells treated with OPZ or NK-252 show increased resistance to H2O2-induced cytotoxicity compared with control cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Rats on a choline-deficient L-amino acid–defined (CDAA) diet given OPZ or NK-252 display decreased fibrosis scores compared with CDAA control rats, with median scores of 3, corresponding to bridging fibrosis. CDAA control rats display approximately 20-fold augmentation of the liver fibrosis area compared with rats fed a normal control diet (naive) (14.7 and 0.72%, respectively).This augmentation is also drastically reduced by administration of OPZ or NK-252 (5.80% for OPZ, 6.20% for NK-252_low, and 4.97% for NK-252_high). The effects of NK-252 on both fibrosis score and fibrosis area are dose-dependent[1]. NK-252 alone has no antitumour effect in P388/S- and P388/VCR-mice. The combination therapy of Etoposide with NK-252 administered p.o. significantly increases the life-span of mice inoculated i.p. with P388/S compared with the corresponding therapeutic effects with Etoposide alone. The combination therapy with Etoposide and NK-252 significantly increases the life-span of mice inoculated i.p. with P388/VCR compared with the corresponding survival time with Etoposide alone[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

285.26

Formula

C13H11N5O3
CAS 号

1414963-82-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 29 mg/mL (101.66 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5056 mL 17.5279 mL 35.0557 mL
5 mM 0.7011 mL 3.5056 mL 7.0111 mL
10 mM 0.3506 mL 1.7528 mL 3.5056 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.29 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (7.29 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.29 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (7.29 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.29 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (7.29 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Shimozono R et al. Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol Pharmacol. 2013 Jul, 84(1):62-70.

    [2]. Kiue A, et al. Enhancement of antitumour activity of etoposide by dihydropyridines on drug-sensitive and drug-resistant leukaemia in mice. Br J Cancer. 1991 Aug;64(2):221-6.
Cell Assay
[1]

The Huh-7.5 cells, a subline derived from Huh-7 cells, are transfected with ARE/pGL4.32 by lipofectamine LTX. The stable clonal transfectant is isolated by selection in hygromycin B (0.1 mg/mL). Cells derived from stable clones are transfected with control or Nrf2 small interfering RNA by lipofectamine RNAiMAX (30 hours), then treated with OPZ, NK-252 (0.1-30 μM, 16 hours) , or DMSO alone (control). The luciferase activity values are measured using the Steady-Glo Luciferase Assay System[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[1][2]

Rats[1]
Six-week-old male Fischer 344 rats are randomly divided into four compound administration groups and four control groups. Compound administration groups of rats fed a CDAA diet receive oral administration as follows: 1) OPZ from 1 week after feeding at a dose of 60 mg/kg once daily for 9 weeks (CDAA+OPZ group; N=8), 2) NK-252 from 1 week after feeding at a dose of 20 mg/kg once daily for 9 weeks (CDAA+NK-252_low group; N=8), 3) NK-252 from 1 week after feeding at a dose of 60 mg/kg once daily for 9 weeks (CDAA+NK-252_high group; N=8), or 4) NK-252 from 6 weeks after feeding at a dose of 60 mg/kg once daily for 4 weeks (CDAA+NK-252_delayed administration: DA group; N=7). Two control groups of rats are fed a CDAA diet for 6 or 10 weeks (pre-CDAA control or CDAA control group; N=9 each), and the other two control groups of rats are fed standard rodent chow (CRF-1) for 6 or 10 weeks (prenaive or naive; N=3 each). Laparotomy and blood sampling are performed under isoflurane anesthesia. After blood sampling, rats are euthanized by exsanguination under isoflurane anesthesia, and the livers are immediately extirpated. [2]Mice[2]
Six- to 8-week-old male BALB/c x DBA/2 F1 (hereafter called CD2F1) mice weighing 22 to 26 g are used. Male CD2F1 mice are inoculated i.p. with 106 cells of P388/S and P388/VCR cell line on day 0. Each group consist of six mice. NK-250 and NK-252 (100, 300, and 1000 mg/kg) are given p.o. daily from day 1 to 5. Mean survival days and the range of survival days are analysed.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

  • [1]. Shimozono R et al. Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol Pharmacol. 2013 Jul, 84(1):62-70.

    [2]. Kiue A, et al. Enhancement of antitumour activity of etoposide by dihydropyridines on drug-sensitive and drug-resistant leukaemia in mice. Br J Cancer. 1991 Aug;64(2):221-6.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

MR-VP

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上海金畔生物科技有限公司可以定制生产国产培养基，可以访问官网了解更多产品信息。
MR-VP

：
英文名称：
产品货号： GS003
产品规格： 20支
35元
保质期： 一年
产品用途： 用于大肠杆菌、O157菌、单增李斯特菌、肠杆菌科等的生化鉴定，需配套甲基红试剂盒及V-P试剂盒使用
备  注：

产品介绍:

用途：

用于大肠杆菌、O157菌、单增李斯特菌、肠杆菌科等的生化，需配套甲基红试剂盒及V-P试剂盒使用。

试验方法：

1、甲基红（MR）试验
取适量琼脂培养物接种于缓冲葡萄糖蛋白胨水（MR-VP），36 ℃±1 ℃培养2 d～5 d。滴加甲基红试剂(此试剂需另行购买)一滴，立即观察结果。鲜红色为阳性，黄色为阴性。
2、V-P试验
取适量琼脂培养物接种于缓冲葡萄糖蛋白胨水（MR-VP），36 ℃±1 ℃培养2 d～4 d,滴加V-P试剂盒(此试剂需另行购买)充分振摇试管，观察结果。阳性反应立刻或于数分钟内出现红色，如为阴性，应放在36℃±1 ℃继续培养4 h 再进行观察。

MR-VP实验操作视频：.aspvideo/MR-VP.asp

不同细菌在MR-VP实验中的生化反应现象：

MR-VP生化管微生物灵敏度试验:

接种以下质控菌株，放置36±1℃需氧培养48±2小时。

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电子分析天平（外校）FA1604 160g

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电子分析天平（外校）FA1604 160g

电子分析天平（外校）FA1604 160g

  • 商品品牌： 良平
    商品编号：FA1604
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    • 电子分析天平（外校）FA1604 160g-良平-FA1604

    • 品牌属性:国产
    • 量程范围:0～210g
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    • 校准:外校
    实验室常用设备|||天平、泵|||实验天平|||电子分析天平（外校）FA1604160g
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    电子分析天平（外校）FA1604 160g

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    ★ 流畅新颖的外形设计，体现了对现代理念的追求。

    ★ 新一代电磁式称量传感器，使产品的进度有了可靠的保障。

    ★ 具有全自动故障检测，自动校准，超载保护等多种应用程序。

    ★ 设有计件、百分比、单位转换等功能，操作简便、可靠。

    ★ 内置RS232C接口，可直接连接计算机、打印机等。

    FA型系列电子分析天平基本结构
    1—1 秤盘 1—2 秤盘座 1—3 水平泡 1—4 开机/关机 1—5 模式 1—6 校准 1—7 单位 1—8 打印 1—9 显示窗 1—10 去皮/置零

    1—11 RS232 接口 1—12电源适配器插座 1—13 水平调节脚

    维护保养

    1、称量物料应使用称量纸、称量杯，严禁直接在称量台上称取物料，而且要特别注意秤盘和外盘不能碰撞。

    2、使用电子天平后应及时擦拭称量台，防止药品洒落。

    3、称量毒性、腐蚀性药品时，应用特制容器盛放，防止污染天平。

    4、有固体粉末沾染在电子天平表面的，先用软毛刷轻轻除去粉末，再用软纱布蘸取中性洗涤剂擦拭。

    5、有液体试剂沾染在电子天平表面的，先用卷筒纸轻轻吸去液体，再用软纱布蘸取中性洗涤剂擦拭。

    6、定期请有关专业人员对天平进行校准。

    7、保持天平适度适用，保持外壳和操作面板的情节，必要时使用沾有温和型清洁剂的湿布擦洗。

    8、保持校准砝码在干燥安全的地方。

    商品属性

    • 品牌属性:国产
    • 量程范围:0～210g
    • 精度:0.1mg
    • 校准:外校
    商品属性
    商品名称 电子分析天平（外校）FA1604 160g-FA1604-良平
    型号 FA1604
    类别 实验室常用设备|||天平、泵|||实验天平|||电子分析天平（外校）FA1604160g
    品牌 良平
    品牌简介 良平
    关键字 天称 电子天平,天平,电子天平,秤盘,量程,洗涤剂,纱布

    电子分析天平（外校）FA1604 160g

    AMXI-5001 hydrochloride

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    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    AMXI-5001 hydrochloride 

    AMXI-5001 hydrochloride 是一种有效的、具有口服活性的 parp1/2 和微管聚合抑制剂。MXI-5001 hydrochloride 对多种人类癌细胞表现出选择性抗肿瘤细胞毒性，其 IC50s 比现有的临床 PARP1/2 抑制剂低得多。AMXI-5001 hydrochloride 诱导已建立的肿瘤完全消退，包括非常大的肿瘤。

    AMXI-5001 hydrochloride

    AMXI-5001 hydrochloride Chemical Structure

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    AMXI-5001 hydrochloride 的其他形式现货产品:

    AMXI-5001

    生物活性

    AMXI-5001 hydrochloride is a potent, orally active, and dual parp1/2 and microtubule polymerization inhibitor. MXI-5001 hydrochloride exhibits selective antitumor cytotoxicity across a wide variety of human cancer cells with much lower IC50s than existing clinical PARP1/2 inhibitors. AMXI-5001 hydrochloride induces complete regression of established tumors, including exceedingly large tumors[1].

    分子量

    493.92

    Formula

    C25H21ClFN5O3
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Lemjabbar-Alaoui H, et al. AMXI-5001, a novel dual parp1/2 and microtubule polymerization inhibitor for the treatment of human cancers. Am J Cancer Res. 2020;10(8):2649-2676.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    美国UVP-SI-950紫外线培养箱

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    【简单介绍】

    品牌 其他品牌 加工定制 是

    美国UVP SI-950紫外线培养箱，内置短波紫外线灯，门开时，安全装置自动断开紫外电源。

    标配含主机，2块搁板，短波紫外灯

    SI-950微培养箱目的是提供精确的温度控制和均匀性，内置短波254nm紫外线灯消毒。

    【详细说明】

    美国UVP SI-950紫外线培养箱

    产品简述

      SI-950型紫外线培养箱内置短波紫外线灯，门开时，安全装置自动断开紫外电源。

    标配含主机，2块搁板，短波紫外灯

    SI-950微培养箱目的是提供精确的温度控制和均匀性，内置短波254nm紫外线灯消毒。

    主要特点

    • 占用面积小，有效容积27L，设计精巧

    • 不锈钢内控，易清洗

    • 微处理器控制，保证温度精确，稳定

    • 加热装置和强制空气对流保证温度分部均匀

    • 透明丙烯酸结构观察窗，看样品时不用打开门

    • 内置254nm短波紫外线灯，防止交叉污染

    • 开门时，安全装置自动断开紫外电源

    • 紫外线灯，温度相互分别控制

    • 两块搁板，面积337X216mm，三个位置可调

    • 温度：室温-68℃

    美国UVP SI-950紫外线培养箱

    技术规格

    技术规格
    搁板 两块通风式搁板
    温度 68℃
    精度 ±1℃
    均匀性 ±0.5摄氏度（37℃时）
    构造 不锈钢内控
    容积 27L
    外箱 445X375X457mm；搁板面积216x337mm

    型号

    订货信息
    95-0358-02 SI-950 UV Incubator
    10-0341-08 搁板
    34-0007-01 灯管 8 watt, 波长254nm

     

    硅烷-PEG-巯基, ,Silane PEG thiol, Silane-PEG-SH,

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    硅烷-PEG-巯基

    MW 1000 Da

    有货

    硅烷-PEG-巯基, ,Silane PEG thiol, Silane-PEG-SH,

    品牌：Jinpan
    Silane PEG thiol, Silane-PEG-SH

    MSDS

    质检证书(CoA)

    相似产品

    货号 (SKU) 包装规格 是否现货 价格 数量
    S164268-100mg 100mg 现货 硅烷-PEG-巯基, ,Silane PEG thiol, Silane-PEG-SH,  
    S164268-500mg 500mg 现货 硅烷-PEG-巯基, ,Silane PEG thiol, Silane-PEG-SH,  

    基本信息

    产品名称 硅烷-PEG-巯基
    英文名称 Silane PEG thiol, Silane-PEG-SH
    规格或纯度 MW 1000 Da
    运输条件 超低温冰袋运输

    一般描述

    Ethoxy or methoxyl silane functionalized polyethylene glycol, silane PEG (PEG-Si) is a surface reactive PEG derivative that can be used to modify glass, silica and other surfaces via the reaction between hydroxyl group and ethoxyl/methoxyl silane. Pegylation can greatly suppress the non-specific binding of charged molecules to the modified surfaces. And they have wide applications for medica device, biomems or biocompatible material development.

    Ethoxy or methoxyl silane functionalized polyethylene glycol, silane PEG (PEG-Si) is a surface reactive PEG derivative that can be used to modify glass, silica and other surfaces via the reaction between hydroxyl group and ethoxyl/methoxyl silane. Pegylation can greatly suppress the non-specific binding of charged molecules to the modified surfaces. And they have wide applications for medica device, biomems or biocompatible material development.

    相关属性

    溶解性 Off-white/white solid or viscous liquid depends on molecule weight;Soluble in regular aqeous solution as well as most organic solvents;
    储存温度 -20°C储存
    品牌 Jinpan
    备注 卖完停产，不再备货

    Tanshinone I(Synonyms: Tanshinone A)

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    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Tanshinone I (Synonyms: Tanshinone A) 纯度: ≥98.0%

    Tanshinone I 是一种IIA型人重组 sPLA2 和兔重组 cPLA2 抑制剂，IC50 分别为 11 μM 和 82 μM。

    Tanshinone I(Synonyms: Tanshinone A)

    Tanshinone I Chemical Structure

    CAS No. : 568-73-0

    规格 价格 是否有货 数量
    5 mg ￥400 In-stock
    10 mg ￥570 In-stock
    25 mg ￥1200 In-stock
    50 mg ￥1900 In-stock
    100 mg ￥2700 In-stock
    200 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    Tanshinone I 相关产品

    •相关化合物库:

    • Natural Product Library Plus
    • Bioactive Compound Library Plus
    • Metabolism/Protease Compound Library
    • Natural Product Library
    • Anti-Cancer Compound Library
    • Anti-Cardiovascular Disease Compound Library
    • Terpenoids Library
    • Traditional Chinese Medicine Monomer Library
    • Lipid Metabolism Compound Library

    生物活性

    Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 (IC50=11 μM) and rabbit recombinant cPLA2 (IC50=82 μM).

    IC50 & Target

    IC50: 11 μM (sPLA2), 82 μM (cPLA2)[1].
    体外研究
    (In Vitro)

    Tanshinone I inhibits PGE2 formation from LPS-induced RAW macrophages (IC50=38 μM). When Tanshinone I is added simultaneously with LPS, this compound clearly inhibits PGE2 production (IC50=38 μM) at 10-100 μM. Tanshinone I also reduces PGE2 production (IC50=46 μM) when added after COX-2 is fully induced. The fact that Tanshinone I inhibits PGE2 production by pre-induced COX-2 strongly suggests that this compound may directly inhibit COX-2 activity and/or affect PLA2 activity. When Tanshinone I is incubated with two different forms of phospholipase A2 (PLA2), it clearly inhibits sPLA2 (IC50=11 μM) in a concentration-dependent manner. Although being less potent, Tanshinone I also inhibits cPLA2 (IC50=82 μM)[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    体内研究
    (In Vivo)

    Tanshinone I shows antiinflammatory activity in rat carrageenan-induced paw oedema and adjuvant-induced arthritis. In order to establish the anti-inflammatory activity of Tanshinone I, the classical animal models of acute and chronic inflammation [rat carrageenan (CGN)-induced paw oedema and rat adjuvant-induced arthritis (AIA)] are employed. When Tanshinone I is orally administered, it shows significant anti-inflammatory activity against CGN-induced paw oedema (47% inhibition at 160 mg/kg), while the IC50 of indomethacin is 7.1 mg/kg. In AIA, Tanshinone I gives 27% inhibition of secondary inflammation at 18 day with an oral dose of 50 mg/kg/day, whereas prednisolone (5 mg/kg/day) shows potent inhibition (65%)[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    276.29

    Formula

    C18H12O3
    CAS 号

    568-73-0
    中文名称

    丹参酮 I
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    DMSO : 2 mg/mL (7.24 mM; Need ultrasonic)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 3.6194 mL 18.0969 mL 36.1939 mL
    5 mM 0.7239 mL 3.6194 mL 7.2388 mL
    10 mM — — —

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
    参考文献

    • [1]. Kim SY, et al. Effects of Tanshinone I isolated from Salvia miltiorrhiza bunge on arachidonic acid metabolism and in vivo inflammatory responses. Phytother Res. 2002 Nov;16(7):616-20.
    Kinase Assay
    [1]

    As sources of PLA2, human recombinant sPLA2 (type IIA) is purified from CHO cells transfected with the PLA2 gene and rabbit recombinant platelet cPLA2 is obtained through its expression in baculovirus. The standard reaction mixture (200 μL) contained 100 mM Tris-HCl buffer (pH 9.0) with 6 mM CaCl2 and 20 nmol 1-acyl-[1-14C]-arachidonyl-sn-glycerophosphoethanolamine (2000 cpm/nmol) in the presence or absence of Tanshinone I. The reaction is started by adding 50 ng purified sPLA2 or cPLA2. After 20 min at 37°C, the free fatty acid generated is analysed. Under these standard conditions, the reaction mixture in the absence of Tanshinone I released approximately 10% of free fatty acid from the phospholipid substrate added[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    Cell Assay
    [1]

    RAW 264.7 cells are cultured with DMEM supplemented with 10% FBS and 1% antibiotics under 5% CO2 at 37°C. Briefly, cells are plated in 96-well plates (2×105 cells/well). LPS (1 ug/mL) and Tanshinone I are simultaneously added and incubated for 24 h, unless otherwise specified. The PGE2 concentration in the medium is measured using an EIA kit for PGE2. In order to determine the effects of Tanshinone I on PGE2 production after induction of COX-2, cells are incubated with LPS (1 ug/mL) for 24 h and thoroughly washed. Then, Tanshinone I is added without LPS and the cells are incubated for another 24 h. From the medium, PGE2 concentrations are measured. The cytotoxicity of Tanshinone I to RAW cells is checked using the MTT assay. Tanshinone I does not show any cytotoxicity up to 100 uM[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [1]

    Mice[1]
    In order to evaluate the inhibitory activity of Tanshinone I against animal models of acute and chronic inflammation, rat carrageenan (CGN)-induced paw oedema and adjuvant-induced arthritis (AIA) models are employed. Briefly, 1% CGN dissolved in pyrogen-free saline (0.05 mL) is injected into right hind paw of rats for the paw oedema test. After 5 h, swelling of the treated paw is measured using a plethysmometer. Tanshinone I dissolved in 0.5% CMC is administered orally 1 h prior to CGN injection. For the AIA test, an arthritic inflammation is provoked by injection of Mycobacterium Butyricum (0.6 mL/rat) dissolved in mineral oil to the right hind paw of rats. Tanshinone I is orally administered every day. The swelling of the treated and untreated paws is measured using a plethysmometer.

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    • [1]. Kim SY, et al. Effects of Tanshinone I isolated from Salvia miltiorrhiza bunge on arachidonic acid metabolism and in vivo inflammatory responses. Phytother Res. 2002 Nov;16(7):616-20.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    Corning康宁 96孔V底未处理表面微孔板 （3896）

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    Corning康宁 96孔V底未处理表面微孔板 （3896）

    Corning康宁 96孔V底未处理表面微孔板 （3896）

  • 商品品牌： Corning康宁
    商品编号：3896
  • 商品价格： 请与我们联系

    • Corning康宁 96孔V底未处理表面微孔板 （3896）-Corning康宁-3896

    • 产品类型:96孔
    • 底部特征:V形底
    • 颜色:透明
    • 品牌属性:进口
    实验室耗材|||分子生物|||微孔板|||Corning康宁96孔V底未处理表面微孔板（3896）
    Corning康宁 96孔V底未处理表面微孔板

    Corning康宁 96孔V底未处理表面微孔板 （3896）

    产品描述

    1、细胞培养板经过伽马射线灭菌

    2、经认证无热源

    3、可根据需要配盖子

    4、Corning CellBIND表面优化以细胞为基础的检测性能

    应用在96和384孔黑透明底微孔板和96孔全透明微孔板上表面

    处理改善一致性，使细胞吸附更均匀，并且可以改善不易吸附

    的细胞系的附着无包被，不需要特殊的处理，并且在室温可以

    稳定保存

    商品属性

    • 产品类型:96孔
    • 底部特征:V形底
    • 颜色:透明
    • 品牌属性:进口
    商品属性
    商品名称 Corning康宁 96孔V底未处理表面微孔板 （3896）-3896-Corning康宁
    型号 3896
    类别 实验室耗材|||分子生物|||微孔板|||Corning康宁96孔V底未处理表面微孔板（3896）
    品牌 Corning康宁
    品牌简介 Corning康宁
    关键字 Corning康宁 96孔V底未处理表面微孔板,微孔,表面,伽马射线,细胞系,细胞,包被

    Corning康宁 96孔V底未处理表面微孔板 （3896）

    OPSS-PEG-Biotin, Biotin-PEG-PDP Cat. No. PG2-BNOS-5k 5000 Da 100 mg修饰性聚乙二醇

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    上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

    OPSS-PEG-Biotin, Biotin-PEG-PDP

    Cat. No. PG2-BNOS-5k
    Specification 5000 Da
    Unit Size 100 mg
    Price $385.00

    Qty Add to Cart

    Description:

    Ortho-pyridyl disulfide (OPSS) functionalized polyethylene glycol (OPSS PEG) is a thiol (-SH) group reactive PEG derivative that can be used to modify biomolecules or other materials via their available thiol groups. Ortho-pyridyl disulfide reacts with thiol group to form a stable disulfide bond while a thiol pyridyl group is released.

    Physical Properties:

    • Off-white/white solid or viscous liquid depends on molecule weight;
    • Soluble in regular aqeous solution as well as most organic solvents;

    Storage Conditions:

    • Store at -20 0C, dessiccated. Avoid frequent thaw and freeze.
    Documents
    • SDS
    • DataSheet

    Thermo QSP10-1000ul滤芯吸头进口盒装TF102-10-Q

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    Thermo QSP10-1000ul滤芯吸头进口盒装

    • 产品型号：TF102-10-Q
    • 简要描述：Thermo QSP10-1000ul滤芯吸头进口盒装上海金畔生物科技有限公司供应：移液器吸嘴，ELISA试剂盒，动物血清，全系荧光定量PCR耗材，产品包括：PCR单管、八联管、96孔板、384孔板。
    产品咨询在线客服
    • 产品简介

    Thermo QSP10-1000ul滤芯吸头进口盒装 QSP赛默飞吸头100-1000ul加长,带刻度100,200,500,1000ul,带滤芯吸头,盒装无菌，TF102-10-Q  TF112-1000-Q

    包装规格：96/铰链盒，10盒/包装,5包装/箱,4800支/箱

    QSP盒装无菌吸头是用热缩塑料包装的并且证实无RNA酶,DNA酶,DNA,ATP致热源,生物负荷和PCR抑制剂。QSP滤器运用一项小的微米滤器技术有助于阻止气溶胶污染。

    Thermo QSP10-1000ul滤芯吸头进口盒装TF102-10-Q 

    滤芯吸头 加长型吸头

    TF102-10-Q 0.1-10µl 带滤芯加长吸头,带刻度,无色透明,无菌
    TF104-10-Q 0.1-10ul 带滤芯超微吸头,盒装,无色,无菌
    TF112-1000-Q 100-1000ul加长,带刻度100,200,500,1000ul,带滤芯吸头,盒装无菌
    TF112G-1000-Q 100-1000µl带滤芯的阔口加长吸头,无色透
    TF113-100-Q 10-100µl 带滤芯收尖吸头,无色透明,无菌
    TF113-20-Q 2-20µl 带滤芯收尖吸头,无色透明,无菌
    TF118-200-Q 20-200µl带滤芯的阔口吸头,无色透明,无菌
    TF140-200-Q 20-200ul 带滤芯吸头,有刻度,盒装,无色透明,无菌

    滤芯吸头的特点：

    防止交叉污染

    不同于含有能抑制酶促反应的添加剂的其它滤芯类型，滤芯由纯聚乙烯组成。 疏水性的这些烧结颗粒可防止气雾和液体吸入移液器内部。

    滤芯使用机器装载，以确保吸头在制造和包装过程中*不会受损。 经验证不含RNase、DNase、DNA和热原质污染。 此外，所有滤芯吸头包装后都要通过辐射进行预消毒，作为预防生物样品污染的附加措施。

    滤芯吸头通用型移液器。

    Thermo QSP10-1000ul滤芯吸头进口盒装相关推荐：

    PCR耗材

    V1082-M 0.1ml PCR八联管
    V2081-C 0.2ml PCR八联管
    VP1011-C 无裙边96*0.1mlPCR板
    V4801-M 半裙边96*0.1mlPCR板
    VP2011-C 半裙边96*0.2mlPCR板
    V-96AD Roche 480辅助器
    V20122-M 0.2ml PCR十二联管
    V10122-M 0.1ml PCR十二联管
    V21112-C 荧光定量PCR十二联管光学平盖

    ELISA试剂盒

    BS-3898 绵羊白介素2受体(IL-2R)ELISA试剂盒
    BS-3899 绵羊骨钙素（BGP）ELISA试剂盒
    BS-3900 绵羊骨桥素(OPN)ELISA试剂盒
    BS-3901 绵羊胰岛素样生长因子1(IGF-1)ELISA试剂盒
    BS-3902 绵羊免疫球蛋白G(IgG)ELISA试剂盒
    BS-3904 绵羊双特异性酪氨酸磷酸化调节激酶1A(DYRK1A)ELISA试剂盒
    BS-3905 绵羊Dickkopf1(DKK1)ELISA试剂盒
    BS-3906 绵羊促卵泡素(FSH)ELISA试剂盒
    BS-3907 绵羊雌二醇（E2）ELISA试剂盒
    BS-3909 绵羊细胞色素P450（CYP450）ELISA试剂盒
    BS-3910 绵羊红细胞生成素（EPO）ELISA试剂盒
    BS-3912 绵羊绒毛膜促性腺激素(CG)ELISA试剂盒  
    BS-3913 绵羊表皮生长因子(EGF)ELISA试剂盒 

    适应客户：医院检验科PCR实验室，中心实验室，肝病中心；第三方检测机构，科研院所，大专院校，制药厂，试剂生产厂家，疾控中心，检验检疫。 

     

    温馨提示：不可用于临床治疗。

    CK-869

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    CK-869  纯度: 99.74%

    CK-869 是肌动蛋白相关蛋白 2/3 复合体 (ARP2/3) 的抑制剂，其 IC50 值为 7 μM。

    CK-869

    CK-869 Chemical Structure

    CAS No. : 388592-44-7

    规格 价格 是否有货 数量
    10 mM * 1 mL in DMSO ￥990 In-stock
    5 mg ￥900 In-stock
    10 mg ￥1600 In-stock
    25 mg ￥3200 In-stock
    50 mg ￥5600 In-stock
    100 mg ￥9900 In-stock
    200 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

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    •相关化合物库:

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    生物活性

    CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM.

    IC50 & Target

    IC50: 7 μM (ARP2/3)[1].
    体外研究
    (In Vitro)

    CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM[1]. CK-869 significantly inhibits MT polymerization even at a concentration of 25 μM[2].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    394.28

    Formula

    C17H16BrNO3S
    CAS 号

    388592-44-7
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    DMSO : 75 mg/mL (190.22 mM; Need ultrasonic)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.5363 mL 12.6813 mL 25.3627 mL
    5 mM 0.5073 mL 2.5363 mL 5.0725 mL
    10 mM 0.2536 mL 1.2681 mL 2.5363 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

    In Vivo:

    请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

    ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
    分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

    • 1.

      请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (6.34 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (6.34 mM，饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

      将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

    • 2.

      请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (6.34 mM); Suspended solution

      此方案可获得 ≥ 2.5 mg/mL (6.34 mM，饱和度未知) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

      将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
    • 3.

      请依序添加每种溶剂： 10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (6.34 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (6.34 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

    *以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
    参考文献

    • [1]. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12.

      [2]. Yamagishi Y, et al. Use of CK-548 and CK-869 as Arp2/3 complex inhibitors directly suppresses microtubule assembly both in vitro and in vivo. Biochem Biophys Res Commun. 2018 Feb 12;496(3):834-839.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    多肽定制Biotin-Vasoactive Intestinal Peptide, human, bovine, porcine, rat 编码

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    上海金畔生物科技有限公司可以定制不同序列多肽，可以访问官网了解更多产品信息。

    名称 Biotin-Vasoactive Intestinal Peptide, human, bovine, porcine, rat
    编码
    别名 Biotin-Vasoactive Intestinal Peptide, human, bovine, porcine, rat
    纯度 80%，90%，95%，98%，99%
    重量 1mg,5mg,10mg,50mg,100mg,1g
    序列（单字母缩写） Biotin-HSDAVFTDNYTRLRKQMAVKKYLNSILN-NH2
    序列（三字母缩写） Biotin-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
    基本描述
    溶解度
    分子量 3552.14
    化学式 C157H252N46O44S2
    存储条件 Store at -20°C. Keep tightly closed. Store in a cool dry place.
    注释
    Documents Biotin-Vasoactive Intestinal Peptide, human, bovine, porcine, rat 编码
    Figures Biotin-Vasoactive Intestinal Peptide, human, bovine, porcine, rat 编码
    Reference
    C端
    N端
    化学桥

    Ar-V7-IN-1

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    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Ar-V7-IN-1 

    Ar-V7-IN-1 是一种有效的 Ar-V7 抑制剂。AR-V7 是雄激素受体的一种激素非依赖性剪接变体。Ar-V7-IN-1具有研究各种适应症的潜力，特别是前列腺癌等癌症 (信息提取自专利 WO2018114781A1, 化合物 43)。

    Ar-V7-IN-1

    Ar-V7-IN-1 Chemical Structure

    CAS No. : 2230880-25-6

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Ar-V7-IN-1 is a potent inhibitor of Ar-V7. AR-V7 is a hormone-independent splice variant of the androgen receptor. Ar-V7-IN-1 has the potential for the research of various indications, in particular cancers such as prostate cancer (extracted from patent WO2018114781A1, compound 43)[1].

    分子量

    394.09

    Formula

    C10H10Br2N4OS
    CAS 号

    2230880-25-6
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    参考文献

    • [1]. Fuqiang Ban, et al. Ar-v7 inhibitors. Patent WO2018114781A1.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    单口纯水化验KA6/KA6-1/KA7

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    【简单介绍】

    单口纯水化验KA6/KA6-1/KA7，
    KA7 单口纯水化验
    主体:PP材质
    内衬塑料软管: 保证经过的水流不与金属接触
    阀芯:全塑料阀芯,静态Z大耐压,3Bar

    【详细说明】

    单口纯水化验KA6/KA6-1/KA7

    KA7单口纯水化验

    主体:PP材质
    内衬塑料软管: 保证经过的水流不与金属接触
    阀芯:全塑料阀芯,静态Z    大耐压,3Bar

     

    KA6单口纯水化验

    主体:PP材质
    内衬塑料软管: 保证经过的水流不与金属接触
    阀芯:全塑料阀芯,静态Z大耐压3Bar

     

    KA6-1单口鹅颈纯水化验

    主体:PP材质
    保证经过的水流不与金属接触
    阀芯:全塑料阀芯,静态Z大耐压3Bar

    单口纯水化验KA6/KA6-1/KA7

    产品名称

    型号

    三口

    KA1/KA1-1（肘动）

    三口冷热

    KA1-2

    三口（不锈钢）

    KA1C

     

     

    T型双口

    KA4-4

    单口（低位）

    KA4-1/KA4-2（肘动）

    单口（低位）

    KA4-3

    单口（鹅颈）

    KA5/KA5-1（肘动）

    KA6纯水

     

    遥控水阀

    KA10/KA10B

    壁式水嘴

    KA10-2

    遥控水阀

    KA10/KA10B

    壁式水嘴

    KA10-3

    遥控水阀

    KA10/KA10B

    鹅颈水嘴

    KA10-1

    感应

    KA17

    汽泡式水嘴

    KA14

    遥控气阀

    KB6/KB6B

    壁式气嘴

    KB6-1

    遥控气阀

    KB6/KB6B

    壁式气嘴

    KB6-2/KB6-3

     

     

    PP大水盆

    KP1（800*456*320）

    PP中水盆

    KP2（555*455*310）

    PP小水盆

    KP3（540*335*240）

    PP小水盆

    KP3-1（430*330*280）

    PP小杯槽

    KP4（195*113）

    PP大杯槽

    KP4-1（258*137）

    PP下水口

    KP6

    Diosmetin(Synonyms: 香叶木素)

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    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    Diosmetin (Synonyms: 香叶木素) 纯度: 99.80%

    Diosmetin是抑制人CYP1A酶活性的天然类黄酮, 在HepG2细胞的 IC50值为40 μM。

    Diosmetin(Synonyms: 香叶木素)

    Diosmetin Chemical Structure

    CAS No. : 520-34-3

    规格 价格 是否有货 数量
    Free Sample (0.1-0.5 mg)   Apply now  
    10 mM * 1 mL in DMSO ￥550 In-stock
    50 mg ￥500 In-stock
    100 mg ￥700 In-stock
    200 mg ￥1100 In-stock
    500 mg   询价  
    1 g   询价  

    * Please select Quantity before adding items.

    Diosmetin 相关产品

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    • Oxygen Sensing Compound Library
    • Traditional Chinese Medicine Monomer Library
    • FDA Approved & Pharmacopeial Drug Library
    • Flavonoids Library
    • Food-Sourced Compound Library
    • Targeted Diversity Library

    生物活性

    Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC50 of 40 μM in HepG2 cell.

    IC50 & Target

    IC50: 40 μM (Others, HepG2 cell)[1]
    体外研究
    (In Vitro)

    Diosmetin inhibits cell proliferation in HepG2 cells in a concentration-dependent manner. Untreated HepG2 cells grow well and are observed to have with normal skeletons, whereas cells treated with diosmetin are distorted and a number of them become round and floating[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    体内研究
    (In Vivo)

    Pretreatment with diosmetin significantly reduces serum levels of amylase and lipase; the histological injury; the secretion of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6; myeloperoxidase (MPO) activity, trypsinogen activation peptide (TAP) level, the expression of inducible nitric oxide synthase (iNOS); and the nuclear factor (NF)-κB activation in cerulein-induced acute pancreatitis[2].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    300.26

    Formula

    C16H12O6
    CAS 号

    520-34-3
    中文名称

    香叶木素
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    In Vitro: 

    DMSO : 100 mg/mL (333.04 mM; Need ultrasonic)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 3.3304 mL 16.6522 mL 33.3045 mL
    5 mM 0.6661 mL 3.3304 mL 6.6609 mL
    10 mM 0.3330 mL 1.6652 mL 3.3304 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

    In Vivo:

    请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

    ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
    分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

    • 1.

      请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (8.33 mM); Clear solution

      此方案可获得 ≥ 2.5 mg/mL (8.33 mM，饱和度未知) 的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

      将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

    *以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
    参考文献

    • [1]. Liu B, et al. Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells. Mol Med Rep. 2016 Jul;14(1):159-64.

      [2]. Yu G, et al. Diosmetin ameliorates the severity of cerulein-induced acute pancreatitis in mice by inhibiting the activation of the nuclear factor-κB. Int J Clin Exp Pathol. 2014 Apr 15;7(5):2133-42.
    Cell Assay
    [1]

    Diosmetin is dissolved in DMSO which is maintained at a constant concentration in control samples (2%). HepG2 cells are maintained in a humidified atmosphere of 5% CO2 at 37°C, and cultured in RPMI-1640 medium supplemented with 10% (v/v) fetal bovine serum, 100 U/mL penicillin and 100 U/mL streptomycin. HepG2 cell density is adjusted to 2×104 cells/100 μL, and the cells are seeded into 96-well plates and placed in an incubator overnight (37°C in 5% CO2) to allow for attachment and recovery. MTT analyses are performed. Briefly, cells are pretreated with 5, 10, 15 and 20 μg/mL diosmetin for 24 h. A total of 20 μL MTT solution (5 mg/mL in PBS) solution is transferred to each well to yield a final 120 μL/well and to separate wells a total of 10 μL CCK8 (5 mg/mL in PBS) is transferred. The plates are incubated for 4 h at 37°C in 5% CO2 and the absorbance is recorded at wavelengths of 595 nm and 450 nm, respectively. The half maximal inhibitory concentration (IC50) of diosmetin is calculated[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [2]

    Experimental acute pancreatitis is induced in mice by seven intraperitoneal injection of cerulein (50 μg/kg) at hourly intervals. Diosmetin (100 mg/kg) or vehicle is pretreated 2 h before the first cerulein injection. After 6 h, 9 h, 12 h of the first cerulein injection, the severity of acute pancreatitis is evaluated biochemically and morphologically[2].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    • [1]. Liu B, et al. Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells. Mol Med Rep. 2016 Jul;14(1):159-64.

      [2]. Yu G, et al. Diosmetin ameliorates the severity of cerulein-induced acute pancreatitis in mice by inhibiting the activation of the nuclear factor-κB. Int J Clin Exp Pathol. 2014 Apr 15;7(5):2133-42.

    所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

    LMP744 hydrochloride(Synonyms: MJ-III65 hydrochloride; NSC706744 hydrochloride)

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    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

    LMP744 hydrochloride (Synonyms: MJ-III65 hydrochloride; NSC706744 hydrochloride) 纯度: 99.70%

    LMP744 hydrochloride (MJ-III65 hydrochloride) 是一种 DNA 嵌和剂，是 拓扑异构酶 1 (Top1) 抑制剂，具有抗肿瘤活性。

    LMP744 hydrochloride(Synonyms: MJ-III65 hydrochloride; NSC706744 hydrochloride)

    LMP744 hydrochloride Chemical Structure

    CAS No. : 308246-57-3

    规格 价格 是否有货 数量
    1 mg ￥3500 In-stock
    5 mg ￥9500 In-stock
    10 mg ￥15000 In-stock
    50 mg ￥45000 In-stock
    100 mg   询价  
    200 mg   询价  

    * Please select Quantity before adding items.

    LMP744 hydrochloride 相关产品

    •相关化合物库:

    • Clinical Compound Library Plus
    • Bioactive Compound Library Plus

    生物活性

    LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity[1].

    IC50 & Target

    Top1

     

    体外研究
    (In Vitro)

    The GI50 value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM[2].
    LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle[2].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Cytotoxicity Assay[2]

    Cell Line: P388 and P388 Top1-deficient murine leukemia cells.
    Concentration: 0.1-100 μM
    Incubation Time: 3 days
    Result: Induced dose-dependent accumulation of cells in the S and G2 phases of the cell cycle.

    体内研究
    (In Vivo)

    LMP744 (MJ-III-65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[1].

    上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts[1].
    Dosage: 10, 25, or 50 mg/kg/week, 4 weeks
    Administration: I.V. push via tail vein
    Result: Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity.

    Clinical Trial

    分子量

    488.92

    Formula

    C24H25ClN2O7
    CAS 号

    308246-57-3
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶解性数据
    In Vitro: 

    DMSO : 105 mg/mL (214.76 mM; Need ultrasonic)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.0453 mL 10.2266 mL 20.4532 mL
    5 mM 0.4091 mL 2.0453 mL 4.0906 mL
    10 mM 0.2045 mL 1.0227 mL 2.0453 mL

    *

    请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
    参考文献

    • [1]. Antony S, et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol. 2005 Feb;67(2):523-30.

      [2]. Antony S, et al. Bisindenoisoquinoline bis-1,3-{( 5,6-dihydro-5,11-diketo-11H-indeno [1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity. Mol Pharmacol. 2006 Sep;70(3):1109-20.

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