| 产品名称 | N-去异丁基-N-丙基利福布汀 |
|---|---|
| 英文名称 | N-Desisobutyl-N-propyl Rifabutin |
| 运输条件 | 超低温冰袋运输 |
一类新的利福霉素螺环哌啶基利福霉素和一种抗生素。
A new class of rifamycins spiropiperidylrifamycins and an antibiotic.
| CAS编号 | 75903-10-5 |
|---|---|
| 储存温度 | -20°C储存 |
| 分子量 | 832.98 |
| 分子式 | C45H60N4O11 |
| 品牌 | Jinpan |
| Smiles | CCCN1CCC2(CC1)NC3=C4C(=O)C5=C(C(=C6C(=C5C3=N2)C(=O)[C@H](O6)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]([[ |
| PubChem CID | 46781138 |
| 产品名称 | 25-O-脱乙酰利福布汀 |
|---|---|
| 英文名称 | 25-O-Deacetyl Rifabutin |
| 英文别名 | 25-Hydroxy Rifabutin; 25-O-Deacetylrifabutin; 25-O-Desacetylrifabutin |
| 运输条件 | 超低温冰袋运输 |
25-O-脱乙酰基利福布汀是利福布汀的代谢产物，具有抗菌特性。
25-O-Deacetyl Rifabutin is a metabolite of Rifabutin which exhibits antibacterial properties.
| CAS编号 | 100324-63-8 |
|---|---|
| 熔点 | 150-160° C |
| 溶解性 | Soluble in Chloroform and Methanol |
| 储存温度 | -20°C储存 |
| 分子量 | 804.97 |
| 分子式 | C44H60N4O10 |
| 品牌 | Jinpan |
| Smiles | C[C@H]1/C=C/C=C(/C(=O)NC2=C3C(=NC4(N3)CCN(CC4)C(C)(C)C)C5=C6C(=C(C(=C5C2=O)O)C)O[C@@](C6=O)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([ |
| PubChem CID | 46780568 |
| 产品名称 | 利福布汀 |
|---|---|
| 英文名称 | Rifabutin (LM427) |
| 英文别名 | Ansamycin;(9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-16-(acetyloxy)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1′-(2-methylpropyl)-spiro[9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo[2′,3 |
| 规格或纯度 | 10mM in DMSO |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | Rifabutin (LM427, Ansamycin) is a semisynthetic ansamycin antibiotic, used in the treatment of Mycobacterium avium intracellulare (MAI) and tuberculosis. |
Information
Rifabutin (LM427, Ansamycin) is a semisynthetic ansamycin antibiotic, used in the treatment of Mycobacterium avium intracellulare (MAI) and tuberculosis.
In vitro
Rifabutin has a broad spectrum of antimicrobial activity. Rifabutin is considerably more active than rifampin in vitro against the Mycobacterium avium complex (MAC), Mycobacterium tuberculosis, and Mycobacterium leprae. Rifabutin also is active against most atypical mycobacteria, including Mycobacterium kansasii, but Mycobacterium chelonae is relatively resistant. Rifabutin also is active against staphylococci, group A streptococci, Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Haemophilus ducreyi, Campylobacter jejuni, Helicobacter pylori, Chlamydia trachomatis, and Toxoplasma gondii. Rifabutin shows an isoenzyme-selectivity profile similar to that produced by Rifampicin, but the maximally achievable induction of cytochrome P-450 3A by Rifabutin is about two-fold lower compared with Rifampicin. Rifabutin enhances the glucuronidation of 1-naphthol, 4-hydroxybiphenyl and beta-estradiol by a factor of two to three.
In vivo
Rifabutin increases the human CYP3A4 mRNA expression, CYP3A4 protein content, testosterone 6ss-hydroxylase activity and dexamethasone 6-hydroxylase activity by 7.4-, 3.0-, 2.4- and 1.9-fold, respectively, in the chimeric mice. Rifabutin (100 mg/kg) combined with Pyrimethamine (10 mg/kg) protects 75% of the mice infected with a lethal inoculum of tachyzoites or cysts of Toxoplasma gondii against death.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥98%
| CAS编号 | 72559-06-9(DMSO) |
|---|---|
| 储存温度 | -80℃储存 |
| 分子量 | 847 |
| 分子式 | C46H62N4O11 |
| 品牌 | Jinpan |
| Smiles | COC1C=COC2(C)OC3=C(C2=O)C4=C(C(=C3C)O)C(=O)C(=C5NC6(CCN(CC6)CC(C)C)N=C45)NC(=O)/C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C1C)C |
