5,7,4′-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4′-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4′-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner[1].
IC50 & Target
Caspase-3
PARP
分子量
312.32
Formula
C18H16O5
CAS 号
5631-70-9
中文名称
5,7,4′-三甲氧基黄酮
运输条件
Room temperature in continental US; may vary elsewhere.
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
[1]. Kim H, et al. Induction of ER Stress-Mediated Apoptosis by the Major Component 5,7,4′-TrimethoxyflavoneIsolated from Kaempferia parviflora Tea Infusion. Nutr Cancer. 2018 Aug-Sep;70(6):984-996.
Chemical structure: benzenoid17-DMAG has been used to block the NF-κB inflammatory cascade in the murine model. It a potential therapeutic agent for non-small-cell lung cancers (NSCLC).
Description
Chemical structure: benzenoid17-DMAG has been used to block the NF-κB inflammatory cascade in the murine model. It a potential therapeutic agent for non-small-cell lung cancers (NSCLC).