【编号】:VIP(XL)80070
【产品名称】:苯乙双胍对照品
【规格】:5mg;98%
【用途】:
【编号】:VIP(XL)80070
【产品名称】:苯乙双胍对照品
【规格】:5mg;98%
【用途】:
产品名称 | 苯乙霉素E |
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英文名称 | Phenelfamycin E |
英文别名 | LL-E 19020; Ganefromycin-α |
运输条件 | 超低温冰袋运输 |
苯乙霉素E是由几种链霉菌产生的苯乙霉素复合物的主要类似物。苯丙霉素是有效的抗生素,对革兰氏+ ve细菌具有很好的活性,特别是难辨梭状芽胞杆菌,而苯丙霉素E
Phenelfamycin E is the major analogue of the phenelfamycin complex produced by several species of Strepyomyces. The phenelfamycins are potent antibiotics with good activity against Gram +ve bacteria, nobably Clostridium difficile, however phenelfamycin E
CAS编号 | 114451-31-9 |
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溶解性 | Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility. |
储存温度 | -20°C储存 |
分子量 | 1226.44 |
分子式 | C65H95NO21 |
品牌 | Jinpan |
Smiles | C/C=C\\C=C\\[C@H]1C([C@H]([C@H]([C@H](O1)(C(CO[C@@H]2C[C@H](C([C@H](O2)C)O[C@H]3C[C@@H]([C@ |
PubChem CID | 25077593 |
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Phenformin hydrochloride (Synonyms: 盐酸苯乙福明; Phenethylbiguanide hydrochloride) 纯度: 98.12%
Phenformin hydrochloride 是一种双胍类的抗糖尿病药,能够使 AMPK 活化。
Phenformin hydrochloride Chemical Structure
CAS No. : 834-28-6
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in Water | ¥500 | In-stock | |
500 mg | ¥400 | In-stock | |
1 g | ¥500 | In-stock | |
5 g | ¥990 | In-stock | |
10 g | 询价 | ||
50 g | 询价 |
* Please select Quantity before adding items.
生物活性 |
Phenformin hydrochloride is an anti-diabetic drug from the biguanide class, can activate AMPK activity. |
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IC50 & Target[2] |
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体外研究 (In Vitro) |
Phenformin stimulates the phosphorylation and activation of AMPKalpha1 and AMPKalpha2 without altering LKB1 activity[1]. Phenformin increases AMPK activity and phosphorylation in the isolated heart, the increase in AMPK activity is always preceded by and correlated with increased cytosolic [AMP][2]. Phenformin is a 50-fold more potent inhibitor of mitochondrial complex I than metformin. Phenformin robustly induces apoptosis in LKB1 deficient NSCLC cell lines. Phenformin at 2 mM similarly induces AMPK signaling as shown by increased P-AMPK and P-Raptor levels. Phenformin induces higher levels of cellular stress, triggering induction of P-Ser51 eIF2α and its downstream target CHOP, and markers of apoptosis at later times. Phenformin induces a significant increase in survival and therapeutic response in KLluc mice following long-term treatment[3]. Phenformin and AICAR increases AMPK activity in H441 cells in a dose-dependent fashion, stimulating the kinase maximally at 5-10 mm and 2 mm, respectively. Phenformin significantly decreases basal ion transport (measured as short circuit current) across H441 monolayers by approximately 50% compared with that of controls. Phenformin and AICAR significantly reduce amiloride-sensitive transepithelial Na+ transport compared with controls. Phenformin and AICAR suppress amiloride-sensitive Na+ transport across H441 cells via a pathway that includes activation of AMPK and inhibition of both apical Na+ entry through ENaC and basolateral Na+ extrusion via the Na+,K+-ATPase[4]. Phenformin-treated rats reveals a tendency towards a decrease in blood insulin level (radioimmunoassay)[5]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Phenformin increases levels of P-eIF2α and its target BiP/Grp78 in normal lung as well as in lung tumors of mice[3]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 |
241.72 |
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Formula |
C10H16ClN5 |
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CAS 号 |
834-28-6 |
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中文名称 |
盐酸苯乙福明 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
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溶解性数据 |
In Vitro:
H2O : 12.5 mg/mL (51.71 mM; Need ultrasonic) DMSO : 1 mg/mL (4.14 mM; ultrasonic and adjust pH to 2 with 1M HCl) Ethanol : < 1 mg/mL (insoluble) DMF : < 1 mg/mL (insoluble) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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Kinase Assay [2] |
Total AMPK activity is measured using the method of Dagher et al. AMPK activity is quantified in the resuspended pellet as incorporation of 32P from [γ-32P]ATP (10 GBq/mmol) into a synthetic peptide with the specific target sequence for AMPK, the SAMS peptide. Radioactivity is measured using a liquid scintillation counter. Protein content in the solution containing the resupended (NH4)2SO4 pellet is determined using the Bradford method. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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【编号】:VIP(XL)81228
【产品名称】:盐酸苯乙双胍对照品
【规格】:5mg; 98.0%
【用途】: