上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
GW280264X 纯度: 97.36%
GW280264X 是 ADAM10/TACE (ADAM17) 金属蛋白酶抑制剂。GW280264X 有效阻断 TACE (ADAM17) 和 ADAM10,IC50 分别为 8.0 nM 和 11.5 nM。ADAM10/17 可调节胶质母细胞瘤起始细胞的免疫原性。

GW280264X Chemical Structure
CAS No. : 866924-39-2
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥4300 | In-stock | |
10 mg | ¥7500 | In-stock | |
25 mg | ¥15800 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
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GW280264X 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
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- Angiogenesis Related Compound Library
- Anti-Liver Cancer Compound Library
生物活性 |
GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively[1]. ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells[2]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
The proliferation of GS-7 cells was significantly reduced upon treatment with GW280264X or ADAM10/17 co-knockdown[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[2]
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体内研究 (In Vivo) |
Pharmacological inhibition of ADAM10 and ADAM17 improves functional recovery after spinal cord injury (SCI)[3]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
575.72 |
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Formula |
C28H41N5O6S |
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CAS 号 |
866924-39-2 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 125 mg/mL (217.12 mM; ultrasonic and warming and heat to 60°C) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
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参考文献 |
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