上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。
Alexidine
Alexidine 是一种双双胍，对多种真菌病原体具有抗真菌 (antifungal) 和抗生物膜活性。Alexidine 还具有一种抗肿瘤活性，靶向哺乳动物细胞中的线粒体酪氨酸磷酸酶 PTPMT1，并导致线粒体凋亡 (apoptosis)。
Alexidine Chemical Structure
CAS No. : 22573-93-9
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| 250 mg | 询价 | ||
| 500 mg | 询价 |
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Alexidine 的其他形式现货产品:
| 生物活性 |
Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis[1]. |
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| 体外研究 (In Vitro) |
With the treatment of Alexidine (10 µM, 24 hours), biofilm community can be decimated[1]..With the treatment of Alexidine (0-60 μg/ml, 24 hours), Alexidine can kill HUVECs and lung A549 cells[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay
Cell Viability Assay
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| 体内研究 (In Vivo) |
With the treatment of Alexidine (Jugular vein-catheterized, 48 hours, 3 µg/ml, once) for 48 hours, Alexidine can decimate preformed biofilms growing in the jugular vein catheters of mice[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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| 分子量 |
508.79 |
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| Formula |
C26H56N10 |
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| CAS 号 |
22573-93-9 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 参考文献 |
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