Deac-SS-Biotin is a potent antitumor agent. Deac-SS-Biotin uptakes into the cells through biotin-mediated internalization. Deac-SS-Biotin combined with DTT (Glutathione mimetic) can effectively inhibit microtubule assembly and displays greater antitumor activity[1].
体外研究 (In Vitro)
Deac-SS-Biotin (compound 9) (5 µM; 24 h) has a remarkable reduction-responsive drug release[1]. Biotin effectively preventes Deac-SS-Biotin from binding to biotin receptor, thereby blocking the cellular uptake of Deac-SS-Biotin[1]. Deac-SS-Biotin (5 µM, 5 µM and 10 µM DTT; 0-80 min) effectively inhibits microtubule assembly and displays greater antitumor activity[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay[1]
Cell Line:
SGC-7901, A549, Hela, L929 cells
Concentration:
0-20 µM
Incubation Time:
72 h
Result:
Showed potent antiproliferative activity with IC50s of 0.124, 0.085, 0.108, 4.22 µM for SGC-7901, A549, Hela, L929 cells.
Cell Viability Assay[1]
Cell Line:
A549 cells
Concentration:
0.17 µM
Incubation Time:
Result:
Increased the cell viability from 23.6% to 68.9% with the increase of biotin concentration from 0.075 to 0.60 µM.
分子量
763.94
Formula
C35H45N3O10S3
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Wang C,et al. Design, synthesis, and biological evaluation of biotinylated colchicine derivatives as potential antitumor agents. J Enzyme Inhib Med Chem. 2022 Dec;37(1):411-420.
Deac-SS-Biotin is a potent antitumor agent. Deac-SS-Biotin uptakes into the cells through biotin-mediated internalization. Deac-SS-Biotin combined with DTT (Glutathione mimetic) can effectively inhibit microtubule assembly and displays greater antitumor activity[1].
体外研究 (In Vitro)
Deac-SS-Biotin (compound 9) (5 µM; 24 h) has a remarkable reduction-responsive drug release[1]. Biotin effectively preventes Deac-SS-Biotin from binding to biotin receptor, thereby blocking the cellular uptake of Deac-SS-Biotin[1]. Deac-SS-Biotin (5 µM, 5 µM and 10 µM DTT; 0-80 min) effectively inhibits microtubule assembly and displays greater antitumor activity[1].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay[1]
Cell Line:
SGC-7901, A549, Hela, L929 cells
Concentration:
0-20 µM
Incubation Time:
72 h
Result:
Showed potent antiproliferative activity with IC50s of 0.124, 0.085, 0.108, 4.22 µM for SGC-7901, A549, Hela, L929 cells.
Cell Viability Assay[1]
Cell Line:
A549 cells
Concentration:
0.17 µM
Incubation Time:
Result:
Increased the cell viability from 23.6% to 68.9% with the increase of biotin concentration from 0.075 to 0.60 µM.
分子量
763.94
Formula
C35H45N3O10S3
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Wang C,et al. Design, synthesis, and biological evaluation of biotinylated colchicine derivatives as potential antitumor agents. J Enzyme Inhib Med Chem. 2022 Dec;37(1):411-420.
Deac-SS-Biotin is a potent antitumor agent. Deac-SS-Biotin uptakes into the cells through biotin-mediated internalization. Deac-SS-Biotin combined with DTT (Glutathione mimetic) can effectively inhibit microtubule assembly and displays greater antitumor activity[1].
体外研究 (In Vitro)
Deac-SS-Biotin (compound 9) (5 µM; 24 h) has a remarkable reduction-responsive drug release[1]. Biotin effectively preventes Deac-SS-Biotin from binding to biotin receptor, thereby blocking the cellular uptake of Deac-SS-Biotin[1]. Deac-SS-Biotin (5 µM, 5 µM and 10 µM DTT; 0-80 min) effectively inhibits microtubule assembly and displays greater antitumor activity[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay[1]
Cell Line:
SGC-7901, A549, Hela, L929 cells
Concentration:
0-20 µM
Incubation Time:
72 h
Result:
Showed potent antiproliferative activity with IC50s of 0.124, 0.085, 0.108, 4.22 µM for SGC-7901, A549, Hela, L929 cells.
Cell Viability Assay[1]
Cell Line:
A549 cells
Concentration:
0.17 µM
Incubation Time:
Result:
Increased the cell viability from 23.6% to 68.9% with the increase of biotin concentration from 0.075 to 0.60 µM.
分子量
763.94
Formula
C35H45N3O10S3
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Wang C,et al. Design, synthesis, and biological evaluation of biotinylated colchicine derivatives as potential antitumor agents. J Enzyme Inhib Med Chem. 2022 Dec;37(1):411-420.
7ACC1(Synonyms: 香豆素D1421; DEAC; Coumarin D 1421; D 1421) 纯度: 99.72%
7ACC1(DEAC; Coumarin D 1421; D 1421)能选择性干扰肿瘤微环境乳酸通量,能抑制表达MCT1和MCT4肿瘤细胞的乳酸涌入,但对乳酸流出无影响。
7ACC1 Chemical Structure
CAS No. : 50995-74-9
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10 mM * 1 mL in DMSO
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7ACC1 相关产品
•相关化合物库:
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Anti-Cancer Compound Library
Anti-Cancer Metabolism Compound Library
Targeted Diversity Library
生物活性
7ACC1(DEAC; Coumarin D 1421; D 1421) selectively interfere with lactate fluxes in the lactate-rich tumor microenvironment; inhibits lactate influx but not efflux in tumor cells expressing MCT1 and MCT4 transporters. IC50 value: 0.86 uM(Lactate uptake inhibition) [1] Target: MCT inhibitor; lactate transport inhibitor Contrary to the reference MCT1 inhibitor AR-C155858, 7ACC unexpectedly inhibited lactate influx but not efflux in tumor cells expressing MCT1 and MCT4 transporters. 7ACC delayed the growth of cervix SiHa tumors, colorectal HCT116 tumors, and orthoptopic MCF-7 breast tumors. MCT target engagement was confirmed by the lack of activity of 7ACC on bladder UM-UC-3 carcinoma that does not express functional MCT. 7ACC also inhibited SiHa tumor relapse after treatment with cisplatin. Finally, we found that contrary to AR-C155858, 7ACC did not prevent the cell entry of the substrate-mimetic drug 3-bromopyruvate (3BP) through MCT1, and contributed to the inhibition of tumor relapse after 3BP treatment.
分子量
261.27
Formula
C14H15NO4
CAS 号
50995-74-9
中文名称
香豆素D1421
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Draoui N, et al. Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux. Mol Cancer Ther. 2014 Jun;13(6):1410-8.