Nortriptyline hydrochloride(Synonyms: 盐酸去甲替林; Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Nortriptyline hydrochloride (Synonyms: 盐酸去甲替林; Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride) 纯度: 99.96%

Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) 是三环类抗抑郁药,是 Amitriptyline 的主要活性代谢产物,用于缓解抑郁症症状。Nortriptyline hydrochloride 是有效自噬 (autophagy ) 抑制剂。

Nortriptyline hydrochloride(Synonyms: 盐酸去甲替林; Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride)

Nortriptyline hydrochloride Chemical Structure

CAS No. : 894-71-3

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Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥550 In-stock
50 mg ¥500 In-stock
100 mg   询价  
200 mg   询价  

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相关化合物库:

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  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • FDA-Approved Drug Library
  • Anti-Cancer Compound Library
  • CNS-Penetrant Compound Library
  • Autophagy Compound Library
  • Drug Repurposing Compound Library
  • Anti-COVID-19 Compound Library
  • FDA Approved & Pharmacopeial Drug Library
  • Drug-Induced Liver Injury (DILI) Compound Library
  • Drug Metabolite Library

生物活性

Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride), the main active metabolite of Amitriptyline, is a tricyclic antidepressant used to relieve the symptoms of depression. Nortriptyline hydrochloride is a potent autophagy inhibitor[1][2].

分子量

299.84

Formula

C19H22ClN

CAS 号

894-71-3

中文名称

盐酸去甲替林;去甲替林盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO : 83.33 mg/mL (277.91 mM; Need ultrasonic)

H2O : 7.14 mg/mL (23.81 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3351 mL 16.6756 mL 33.3511 mL
5 mM 0.6670 mL 3.3351 mL 6.6702 mL
10 mM 0.3335 mL 1.6676 mL 3.3351 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.94 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (6.94 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.94 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (6.94 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.94 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (6.94 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US); 2012-2017 Mar 23.

    [2]. Petrosyan E, et al. Repurposing Autophagy Regulators in Brain Tumors [published online ahead of print, 2022 Feb 18]. Int J Cancer. 2022;10.1002/ijc.33965.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Nortriptyline(Synonyms: Desmethylamitriptyline; Desitriptilina)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Nortriptyline (Synonyms: Desmethylamitriptyline; Desitriptilina)

Nortriptyline (Desmethylamitriptyline) 是三环类抗抑郁药,是 Amitriptyline 的主要活性代谢产物,用于缓解抑郁症症状。Nortriptyline 是有效自噬 (autophagy) 抑制剂。

Nortriptyline(Synonyms: Desmethylamitriptyline;  Desitriptilina)

Nortriptyline Chemical Structure

CAS No. : 72-69-5

规格 价格 是否有货 数量
10 mg ¥380 In-stock
50 mg ¥950 In-stock
100 mg ¥1500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Nortriptyline 相关产品

相关化合物库:

  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • FDA-Approved Drug Library
  • Anti-Cancer Compound Library
  • Autophagy Compound Library
  • Drug Repurposing Compound Library
  • Orally Active Compound Library
  • FDA Approved & Pharmacopeial Drug Library
  • Drug-Induced Liver Injury (DILI) Compound Library
  • Drug Metabolite Library
  • Rare Diseases Drug Library

生物活性

Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant used to relieve the symptoms of depression. Nortriptyline is a potent autophagy inhibitor[1][2].

分子量

263.38

Formula

C19H21N

CAS 号

72-69-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献
  • [1]. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. In: Pratt VM, Scott SA, Pirmohamed M, et al., eds. Medical Genetics Summaries. Bethesda (MD): National Center for Biotechnology Information (US); March 23, 2017.

    [2]. Petrosyan E, et al. Repurposing Autophagy Regulators in Brain Tumors [published online ahead of print, 2022 Feb 18]. Int J Cancer. 2022;10.1002/ijc.33965.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务