DBCO-C3-Acid

发表于2023年9月27日由上海金畔生物科技有限公司

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

DBCO-C3-Acid 纯度: ≥95.0%

DBCO-C3-Acid 是一种点击化学 (Click Chemistry) 中间体。DBCO-C3-Acid 可用以合成 ADC linker。

DBCO-C3-Acid Chemical Structure

CAS No. : 1207355-31-4

规格	价格	是否有货
50 mg	￥4600	In-stock
100 mg	￥7500	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

DBCO-C3-Acid is a Click Chemistry intermediate used in the synthesis of antibody-drug conjugate (ADC) linker^[1].

分子量

319.35

Formula

C₂₀H₁₇NO₃

CAS 号

1207355-31-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL (313.14 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1314 mL	15.6568 mL	31.3136 mL
5 mM	0.6263 mL	3.1314 mL	6.2627 mL
10 mM	0.3131 mL	1.5657 mL	3.1314 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (7.83 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (7.83 mM); Suspended solution; Need ultrasonic

此方案可获得 2.5 mg/mL (7.83 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。

参考文献

[1]. van Geel R, et al. Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody-Drug Conjugates. Bioconjug Chem. 2015;26(11):2233-2242.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

DBCO-acid

发表于2023年9月22日由上海金畔生物科技有限公司

DBCO-acid 纯度: 99.63%

DBCO-acid 是一种可降解 (cleavable) ADC linker，可用于合成 ADC linker DBCO-NHS ester (HY-115524 和 HY-115545)，及偶联物 DBCO-PEG-MMAE (HY-111012 和 HY-126690)。

DBCO-acid Chemical Structure

CAS No. : 1353016-70-2

规格	价格	是否有货
10 mM * 1 mL in DMSO	￥500	In-stock
10 mg	￥650	In-stock
50 mg	￥1500	In-stock
100 mg	￥2550	In-stock
200 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

DBCO-acid is a cleavable ADC linker used in the synthesis of ADC linker DBCO-NHS ester (HY-115524 and HY-115545), and drug-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690)^[1].

IC₅₀ & Target

Cleavable

分子量

305.33

Formula

C₁₉H₁₅NO₃

CAS 号

1353016-70-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据

In Vitro:

DMSO : 100 mg/mL (327.51 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.2751 mL	16.3757 mL	32.7515 mL
5 mM	0.6550 mL	3.2751 mL	6.5503 mL
10 mM	0.3275 mL	1.6376 mL	3.2751 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (8.19 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (8.19 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (8.19 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (8.19 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (8.19 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (8.19 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Zimmerman ES, et al. Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system. Bioconjug Chem. 2014 Feb 19;25(2):351-61.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

DBCO-(PEG)3-VC-PAB-MMAE

发表于2023年9月16日由上海金畔生物科技有限公司

DBCO-(PEG)3-VC-PAB-MMAE

DBCO-(PEG)3-VC-PAB-MMAE 由偶联于 DBCO-(PEG)3-vc-PAB 接头的 MMAE 制成。Monomethyl auristatin E (MMAE) 是一种有效的微管蛋白抑制剂，是抗体药物缀合物中的毒素有效载荷。

DBCO-(PEG)3-VC-PAB-MMAE Chemical Structure

规格	价格	是否有货
1 mg	￥8100	In-stock
5 mg (1 mg x 5)	￥22200	In-stock
10 mg (1 mg x 10)	￥35500	In-stock

* Please select Quantity before adding items.

生物活性

DBCO-(PEG)3-VC-PAB-MMAE is made by MMAE conjugated to DBCO-(PEG)3-vc-PAB linker. Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.

IC₅₀ & Target

Auristatin

分子量

1613.97

Formula

C₈₆H₁₂₄N₁₂O₁₈

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据

In Vitro:

DMSO : 60 mg/mL (37.18 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.6196 mL	3.0980 mL	6.1959 mL
5 mM	0.1239 mL	0.6196 mL	1.2392 mL
10 mM	0.0620 mL	0.3098 mL	0.6196 mL

请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: 1.5 mg/mL (0.93 mM); Suspended solution; Need ultrasonic

此方案可获得 1.5 mg/mL (0.93 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 15.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: 1.5 mg/mL (0.93 mM); Suspended solution; Need ultrasonic

此方案可获得 1.5 mg/mL (0.93 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 15.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 1.5 mg/mL (0.93 mM); Clear solution

此方案可获得 ≥ 1.5 mg/mL (0.93 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 15.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

DBCO-NHCO-PEG12-amine

发表于2023年9月14日由上海金畔生物科技有限公司

DBCO-NHCO-PEG12-amine

DBCO-NHCO-PEG12-amine 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。

DBCO-NHCO-PEG12-amine Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

DBCO-NHCO-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

876.04

Formula

C₄₅H₆₉N₃O₁₄

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Dibenzylcyclooctyne, DBCO NHS Cat. No. DB-NS-01 MW 402.40 5 mg修饰性聚乙二醇

发表于2023年9月13日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Dibenzylcyclooctyne, DBCO NHS

Cat. No.	DB-NS-01
Specification	MW 402.40
Unit Size	5 mg
Price	$385.00

Description:

DBCO (Dibenzocyclooctyne) is a cycloalkyne that can reacts with azides via strain-promoted 1,3-dipolar cycloaddition in aqueous solution, a bioorthogonal reaction also termed Cu-free click reaction. This reaction has excellent selectivity and biocompatibility, such that the complimentary reagents can form covalent bonds with richly functionalized biological systems. The Cu-free click reaction has been a powerful tool in catalyst-free bioconjugation. DBCO reagents posses fast kinetcs and stability in aqueous buffer and they can be used to label azide-modified biomolecules with high specificity and reactivity.

Physical Properties:

Yellow/pale-yellow solid or viscous liquid;
Soluble in DMSO or DMF;

Storage Conditions:

Store at -20 ⁰C, desiccate. NHS tends to hydrolyze from moisture. Avoid frequent thaw and frozen.

Reaction Procedures:

NHS esters are moisture senstivie. To avoid moisture condensation onto the product always let vial come to room temperature before opening; be exposure to limit exposure to moisture and restore under atmosphere. The NHS ester moiety readily hydrolyzes and becomes non-reactive; therefore, prepare stock solutions immediately before use. Stock solutions in anhydrous solvents can be kept for several days (freeze when not in use). Hydrolysis of the NHS ester is a competing reaction. Conjugation with primary amines of proteins/peptides (i.e., acylation) is favored at near neutral pH (6-9) and with concentrated protein solutions. For conjugation, use non-amine containing buffers at pH 7-9 such as PBS (20 mM sodium phosphate, 150 mM sodium chloride, pH 7.4); 20 mM HEPES; 100 mM carbonate/biocarbonate; or 50 mM borate buffer. Do not use buffers that contain primary amines, (e.g., Tris, glycine). Avoid buffers that contain azides, which can react with DBCO. Dissolve DBCO water miscible organic solvent such as DMSO or DMF before diluting in final reaction buffer. DBCO-NHS ester is not soluble in aqueous buffers.

Materials Required:

Conjugation buffer: Sodium bicarbonate 100 mM buffer, pH 8.5 or other amine-free buffer at pH 7-8.5.
Water miscible solvents: DMSO or DMF.
Quenching buffer: 1 M Tris.HCl, pH 8.0.

Reaction Steps:

Prepare proteins in PBS. Immediately before use, prepare 10 mM of the DBCO-NHS reagent in DMSO or DMF. Add the NHS reagent to the protein sample at a final: mM. If For samples <5 mg/ml, use a 20 to 50 fold molar excess. Incubate the reaction at room temperature for 30 minutes or on ice for 2 hours. Stop the reaction by adding Quenching Buffer 100 mM Tris.or on ice for 15 minutes. Remove non reagentby dialysis or desalting.

Copper-free Click Reaction:

Prepare the azide-containing sample in reaction buffer. Add DBCO conjugate to azide containing sample. Recommendation: Add 1 mole equivalent of limiting reagent to 1.5-3.0 mole equivalents of highest abundance reagent. Incubate the reaction at room temperature for 2-4 hours or 2-12 hours at 4 degree celcius. The reaction is now ready for purification.

Dibenzylcyclooctyne, DBCO NHS Cat. No. DB-NS-02 MW 402.40 10 mg修饰性聚乙二醇

发表于2023年9月13日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Dibenzylcyclooctyne, DBCO NHS

Cat. No.	DB-NS-02
Specification	MW 402.40
Unit Size	10 mg
Price	$685.00

Description:

Physical Properties:

Yellow/pale-yellow solid or viscous liquid;
Soluble in DMSO or DMF;

Storage Conditions:

Store at -20 ⁰C, desiccate. NHS tends to hydrolyze from moisture. Avoid frequent thaw and frozen.

Reaction Procedures:

Materials Required:

Conjugation buffer: Sodium bicarbonate 100 mM buffer, pH 8.5 or other amine-free buffer at pH 7-8.5.
Water miscible solvents: DMSO or DMF.
Quenching buffer: 1 M Tris.HCl, pH 8.0.

Reaction Steps:

Copper-free Click Reaction:

DBCO-PEG4-NHS Cat. No. DB-NS-EG4-1 5 mg修饰性聚乙二醇

发表于2023年9月12日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DBCO-PEG4-NHS

Cat. No.	DB-NS-EG4-1
Specification
Unit Size	5 mg
Price	$385.00

Description:

Physical Properties:

Yellow/pale-yellow solid or viscous liquid;
Soluble in DMSO or DMF;

Storage Conditions:

Store at -20 ⁰C, desiccate. NHS tends to hydrolyze from moisture. Avoid frequent thaw and frozen.

Reaction Procedures:

Materials Required:

Conjugation buffer: Sodium bicarbonate 100 mM buffer, pH 8.5 or other amine-free buffer at pH 7-8.5.
Water miscible solvents: DMSO or DMF.
Quenching buffer: 1 M Tris.HCl, pH 8.0.

Reaction Steps:

Copper-free Click Reaction:

DBCO-PEG2000-NHS Cat. No. DB-NS-P2k 25 mg修饰性聚乙二醇

发表于2023年9月11日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DBCO-PEG2000-NHS

Cat. No.	DB-NS-P2k
Specification
Unit Size	25 mg
Price	$385.00

Description:

Physical Properties:

Yellow/pale-yellow solid or viscous liquid;
Soluble in DMSO or DMF;

Storage Conditions:

Store at -20 ⁰C, desiccate. NHS tends to hydrolyze from moisture. Avoid frequent thaw and frozen.

Reaction Procedures:

Materials Required:

Conjugation buffer: Sodium bicarbonate 100 mM buffer, pH 8.5 or other amine-free buffer at pH 7-8.5.
Water miscible solvents: DMSO or DMF.
Quenching buffer: 1 M Tris.HCl, pH 8.0.

Reaction Steps:

Copper-free Click Reaction:

DBCO-EG4-NH2 Cat. No. DB-AM-EG4-1 5 mg修饰性聚乙二醇

发表于2023年9月9日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DBCO-EG4-NH2

Cat. No.	DB-AM-EG4-1
Specification
Unit Size	5 mg
Price	$385.00

Description:

Physical Properties:

Yellow/pale-yellow solid or semi-solid;
Soluble in DMSO or DMF;

Storage Conditions:

Store at -20 ⁰C, desiccate. Avoid frequent thaw and frozen.

Copper-free Click Reaction Procedures:

DBCO-PEG2000-NH2 Cat. No. DB-AM-P2k 25 mg修饰性聚乙二醇

发表于2023年9月9日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DBCO-PEG2000-NH2

Cat. No.	DB-AM-P2k
Specification
Unit Size	25 mg
Price	$385.00

Description:

Physical Properties:

Yellow/pale-yellow solid or semi-solid;
Soluble in DMSO or DMF;

Storage Conditions:

Store at -20 ⁰C, desiccate. Avoid frequent thaw and frozen.

Copper-free Click Reaction Procedures:

DBCO-maleimide Cat. No. DB-ML-1 5 mg修饰性聚乙二醇

发表于2023年9月8日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DBCO-maleimide

Cat. No.	DB-ML-1
Specification
Unit Size	5 mg
Price	$385.00

Description:

Physical Properties:

Yellow/pale-yellow solid or semi-solid;
Soluble in DMSO or DMF;

Storage Conditions:

Store at -20 ⁰C, desiccate. Avoid frequent thaw and frozen.

Copper-free Click Reaction Procedures:

DBCO-PEG4-maleimide Cat. No. DB-ML-EG4 5 mg修饰性聚乙二醇

发表于2023年9月7日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DBCO-PEG4-maleimide

Cat. No.	DB-ML-EG4
Specification
Unit Size	5 mg
Price	$385.00

Description:

Physical Properties:

Yellow/pale-yellow solid or semi-solid;
Soluble in DMSO or DMF;

Storage Conditions:

Store at -20 ⁰C, desiccate. Avoid frequent thaw and frozen.

Copper-free Click Reaction Procedures:

DBCO-PEG2000-maleimide Cat. No. DB-ML-P2k 10 mg修饰性聚乙二醇

发表于2023年9月6日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DBCO-PEG2000-maleimide

Cat. No.	DB-ML-P2k
Specification
Unit Size	10 mg
Price	$385.00

Description:

Physical Properties:

Yellow/pale-yellow solid or semi-solid;
Soluble in DMSO or DMF;

Storage Conditions:

Store at -20 ⁰C, desiccate. Avoid frequent thaw and frozen.

Copper-free Click Reaction Procedures:

DBCO PEG Folic acid, ,DBCO PEG Folic acid,

发表于2023年9月5日由上海金畔生物科技有限公司

DBCO PEG Folic acid

MW 1000 Da

有货

品牌：Jinpan

DBCO PEG Folic acid

MSDS

质检证书(CoA)

相似产品

货号 (SKU)	包装规格	是否现货	价格	数量
D163529-5mg	5mg	期货
D163529-25mg	25mg	期货

基本信息

产品名称	DBCO PEG Folic acid
英文名称	DBCO PEG Folic acid
规格或纯度	MW 1000 Da
运输条件	超低温冰袋运输

一般描述

DBCO PEG Folic acid, also called DBCO PEG folate, is one of Nanocs’ folic acid PEG derivatives that can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjμgation of two molecules in aqueous solution. DBCO PEG folate derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneous without the need for toxic Cu catalysts. Folic acid, is also known as vitamin M, vitamin B9 or pteroyl-L-glutamic acid. Folic acid is an essential bioactive molecule for numerous biological functions. It participates in the synthesis, repairing and methylation of DNA as well as to act as a cofactor in many biological reactions. DBCO functional folic acid can be easily attached to azide functionalized molecules, particles or solid surfaces.
Product Describtion:
DBCO PEG Folic acid, also called DBCO PEG folate, is one of Nanocs’ folic acid PEG derivatives that can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjugation of two molecules in aqueous solution. DBCO PEG folate derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneous without the need for toxic Cu catalysts. Folic acid, is also known as vitamin M, vitamin B9 or pteroyl-L-glutamic acid. Folic acid is an essential bioactive molecule for numerous biological functions. It participates in the synthesis, repairing and methylation of DNA as well as to act as a cofactor in many biological reactions. DBCO functional folic acid can be easily attached to azide functionalized molecules, particles or solid surfaces.

敏感性	对光敏感
溶解性	Soluble in DMSO
储存温度	-20°C储存,充氩
品牌	Jinpan

DBCO PEG Thiol, DBCO-PEG-SH, ,DBCO PEG Thiol, DBCO-PEG-SH,

发表于2023年9月5日由上海金畔生物科技有限公司

DBCO PEG Thiol, DBCO-PEG-SH

MW 5000 Da

有货

品牌：Jinpan

DBCO PEG Thiol, DBCO-PEG-SH

MSDS

质检证书(CoA)

相似产品

货号 (SKU)	包装规格	是否现货	价格	数量
D163542-25mg	25mg	现货
D163542-100mg	100mg	现货

基本信息

产品名称	DBCO PEG Thiol, DBCO-PEG-SH
英文名称	DBCO PEG Thiol, DBCO-PEG-SH
别名	Dibenzocycolctyne-PEG-Thiol
英文别名	Dibenzocycolctyne-PEG-Thiol
规格或纯度	MW 5000 Da
运输条件	超低温冰袋运输

一般描述

DBCO (dibenzocycolctyne) PEG thiol (DBCO-PEG-SH) derivatives can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjμgation of two molecules in aqueous solution. DBCO PEG derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneous without the need for toxic Cu catalysts. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

DBCO (dibenzocycolctyne) PEG thiol (DBCO-PEG-SH) derivatives can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjugation of two molecules in aqueous solution. DBCO PEG derivatives possess fast kinetics and stability in aqueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneous without the need for toxic Cu catalysts. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

敏感性	对光敏感；对湿度敏感
储存温度	避光,-20°C储存,充氩
品牌	Jinpan

DBCO-PEG2000-fluorescein Cat. No. PG2-DBFC-2k 10 mg修饰性聚乙二醇

发表于2023年9月5日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DBCO-PEG2000-fluorescein

Cat. No.	PG2-DBFC-2k
Specification
Unit Size	10 mg
Price	$385.00

Description:

Physical Properties:

Yellow/pale-yellow solid or semi-solid;
Soluble in DMSO or DMF;

Storage Conditions:

Store at -20 ⁰C, desiccate. Avoid frequent thaw and frozen.

Copper-free Click Reaction Procedures:

DBCO-PEG2000-Rhodamine B Cat. No. PG2-DBRB-2k 5 mg修饰性聚乙二醇

发表于2023年9月4日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DBCO-PEG2000-Rhodamine B

Cat. No.	PG2-DBRB-2k
Specification
Unit Size	5 mg
Price	$385.00

Description:

Physical Properties:

Yellow/pale-yellow solid or semi-solid;
Soluble in DMSO or DMF;

Storage Conditions:

Store at -20 ⁰C, desiccate. Avoid frequent thaw and frozen.

Copper-free Click Reaction Procedures:

DBCO-PEG2000-Cy3 Cat. No. PG2-DBS3-2k 5 mg修饰性聚乙二醇

发表于2023年9月2日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DBCO-PEG2000-Cy3

Cat. No.	PG2-DBS3-2k
Specification
Unit Size	5 mg
Price	$385.00

Description:

Physical Properties:

Yellow/pale-yellow solid or semi-solid;
Soluble in DMSO or DMF;

Storage Conditions:

Store at -20 ⁰C, desiccate. Avoid frequent thaw and frozen.

Copper-free Click Reaction Procedures:

DBCO-Val-Cit-PABC-OH

发表于2023年9月2日由上海金畔生物科技有限公司

DBCO-Val-Cit-PABC-OH

DBCO-Val-Cit-PABC-OH 是一种可降解 (cleavable) 的 ADC linker，可用于合成抗体偶联药物 (ADC)。

DBCO-Val-Cit-PABC-OH Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

DBCO-Val-Cit-PABC-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Cleavable

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

694.82

Formula

C₃₉H₄₆N₆O₆

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

DBCO-PEG2000-Cy5 Cat. No. PG2-DBS5-2k 5 mg修饰性聚乙二醇

发表于2023年9月2日由上海金畔生物科技有限公司

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

DBCO-PEG2000-Cy5

Cat. No.	PG2-DBS5-2k
Specification
Unit Size	5 mg
Price	$385.00

Description:

Physical Properties:

Yellow/pale-yellow solid or semi-solid;
Soluble in DMSO or DMF;

Storage Conditions:

Store at -20 ⁰C, desiccate. Avoid frequent thaw and frozen.

Copper-free Click Reaction Procedures:

Dibenzylcyclooctyne, DBCO NHS

Dibenzylcyclooctyne, DBCO NHS

DBCO-PEG4-NHS

DBCO-PEG2000-NHS

DBCO-EG4-NH2

DBCO-PEG2000-NH2

DBCO-maleimide

DBCO-PEG4-maleimide

DBCO-PEG2000-maleimide

DBCO PEG Folic acid

基本信息

一般描述

相关属性

DBCO PEG Thiol, DBCO-PEG-SH

基本信息

一般描述

相关属性

DBCO-PEG2000-fluorescein

DBCO-PEG2000-Rhodamine B

DBCO-PEG2000-Cy3

DBCO-PEG2000-Cy5