SNIPER(ABL)-020

发表于2025年4月23日由上海金畔生物科技有限公司

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SNIPER(ABL)-020 纯度: 99.44%

SNIPER(ABL)-020，由 Dasatinib (ABL 抑制剂) 通过 linker 与 Bestatin (IAP 配体) 组合而成，可有效降解 BCR-ABL 蛋白。

SNIPER(ABL)-020 Chemical Structure

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5 mg	￥8500	In-stock
10 mg	￥14500	In-stock
50 mg	￥38000	In-stock
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200 mg		询价

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SNIPER(ABL)-020 相关产品

•相关化合物库:

Bioactive Compound Library Plus

生物活性

SNIPER(ABL)-020, conjugating Dasatinib (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein^[1].

分子量

923.52

Formula

C₄₄H₅₉ClN₁₀O₈S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据

In Vitro:

DMSO : 200 mg/mL (216.56 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.0828 mL	5.4141 mL	10.8281 mL
5 mM	0.2166 mL	1.0828 mL	2.1656 mL
10 mM	0.1083 mL	0.5414 mL	1.0828 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 5 mg/mL (5.41 mM); Clear solution

此方案可获得 ≥ 5 mg/mL (5.41 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 50.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: 5 mg/mL (5.41 mM); Suspended solution; Need ultrasonic

此方案可获得 5 mg/mL (5.41 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。

以 1 mL 工作液为例，取 100 μL 50.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

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SNIPER(TACC3)-11

发表于2024年11月13日由上海金畔生物科技有限公司

SNIPER(TACC3)-11

SNIPER(TACC3)-11 是一种有效的成纤维细胞生长因子受体 3 转化酸性卷曲螺旋蛋白 3 (FGFR3-TACC3) 抑制剂。SNIPER(TACC3)-11 降低 FGFR3-TACC3 蛋白水平，抑制 FGFR3-TACC3 阳性癌细胞的生长。

SNIPER(TACC3)-11 Chemical Structure

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生物活性

SNIPER(TACC3)-11 is a potent FGFR3-TACC3 degrader. SNIPER(TACC3)-11 reduces FGFR3-TACC3 protein levels and suppressed the growth of FGFR3-TACC3 positive cancer cells^[1].

IC₅₀ & Target

FGFR3-TACC3^[1]

体外研究
(In Vitro)

SNIPER(TACC3)-11 (compound 5a) (0.3-3 μM; 6 hours) reduces FGFR3-TACC3 levels^[1].
SNIPER(TACC3)-11 (0.3-3 μM; 72 hours) inhibits the growth of RT4 cells at 3 µM, and does not inhibit the growth of HeLa cells^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	RT4 cells^[1]
Concentration:	0.3, 1 and 3 μM
Incubation Time:	6 hours
Result:	Reduced FGFR3-TACC3 levels.

Cell Proliferation Assay

Cell Line:	RT4 and HeLa cells^[1]
Concentration:	0.3, 1 and 3 μM
Incubation Time:	72 hours
Result:	Dramatically inhibited the growth of RT4 cells at 3 µM, and did not inhibit the growth of HeLa cells, which indicated that SNIPER(TACC3)-11 just inhibited the proliferation of cells expressing FGFR3-TACC3.

分子量

995.26

Formula

C₅₁H₆₆N₁₀O₇S₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Shibata N, Cho N, Koyama H, Naito M. Development of a degrader against oncogenic fusion protein FGFR3-TACC3. Bioorg Med Chem Lett. 2022;60:128584.

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SNIPER(TACC3)-11

发表于2024年11月13日由上海金畔生物科技有限公司

SNIPER(TACC3)-11

SNIPER(TACC3)-11 Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性

SNIPER(TACC3)-11 is a potent FGFR3-TACC3 degrader. SNIPER(TACC3)-11 reduces FGFR3-TACC3 protein levels and suppressed the growth of FGFR3-TACC3 positive cancer cells^[1].

IC₅₀ & Target

FGFR3-TACC3^[1]

体外研究
(In Vitro)

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	RT4 cells^[1]
Concentration:	0.3, 1 and 3 μM
Incubation Time:	6 hours
Result:	Reduced FGFR3-TACC3 levels.

Cell Proliferation Assay

Cell Line:	RT4 and HeLa cells^[1]
Concentration:	0.3, 1 and 3 μM
Incubation Time:	72 hours
Result:	Dramatically inhibited the growth of RT4 cells at 3 µM, and did not inhibit the growth of HeLa cells, which indicated that SNIPER(TACC3)-11 just inhibited the proliferation of cells expressing FGFR3-TACC3.

分子量

995.26

Formula

C₅₁H₆₆N₁₀O₇S₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Shibata N, Cho N, Koyama H, Naito M. Development of a degrader against oncogenic fusion protein FGFR3-TACC3. Bioorg Med Chem Lett. 2022;60:128584.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SNIPER(TACC3)-11

发表于2024年11月13日由上海金畔生物科技有限公司

SNIPER(TACC3)-11

SNIPER(TACC3)-11 Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

* Please select Quantity before adding items.

生物活性

SNIPER(TACC3)-11 is a potent FGFR3-TACC3 degrader. SNIPER(TACC3)-11 reduces FGFR3-TACC3 protein levels and suppressed the growth of FGFR3-TACC3 positive cancer cells^[1].

IC₅₀ & Target

FGFR3-TACC3^[1]

体外研究
(In Vitro)

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	RT4 cells^[1]
Concentration:	0.3, 1 and 3 μM
Incubation Time:	6 hours
Result:	Reduced FGFR3-TACC3 levels.

Cell Proliferation Assay

Cell Line:	RT4 and HeLa cells^[1]
Concentration:	0.3, 1 and 3 μM
Incubation Time:	72 hours
Result:	Dramatically inhibited the growth of RT4 cells at 3 µM, and did not inhibit the growth of HeLa cells, which indicated that SNIPER(TACC3)-11 just inhibited the proliferation of cells expressing FGFR3-TACC3.

分子量

995.26

Formula

C₅₁H₆₆N₁₀O₇S₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Shibata N, Cho N, Koyama H, Naito M. Development of a degrader against oncogenic fusion protein FGFR3-TACC3. Bioorg Med Chem Lett. 2022;60:128584.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SNIPER(TACC3)-2

发表于2024年10月31日由上海金畔生物科技有限公司

SNIPER(TACC3)-2

SNIPER(TACC3)-2 基于IAP E3配体的，通过泛素－蛋白酶体系统靶向降解 TACC3 蛋白。SNIPER(TACC3)-2 诱导癌细胞死亡。

SNIPER(TACC3)-2 Chemical Structure

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生物活性	SNIPER(TACC3)-2 targets the TACC3 protein for degradation via the ubiquitin-proteasome pathway based on IAP ligand. SNIPER(TACC3)-2 induces cancer cell death^[1].
分子量	848.07
Formula	C₄₃H₆₁N₉O₇S
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Ohoka N, et al. Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin-proteasome pathway. Cell Death Dis. 2014 Nov 6;5:e1513.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SNIPER(TACC3)-1

发表于2024年10月31日由上海金畔生物科技有限公司

SNIPER(TACC3)-1

SNIPER(TACC3)-1 基于 IAP E3连接酶，通过泛素－蛋白酶体系统靶向降解 TACC3 蛋白。SNIPER(TACC3)-1 诱导癌细胞死亡。

SNIPER(TACC3)-1 Chemical Structure

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生物活性	SNIPER(TACC3)-1 targets the TACC3 protein for degradation via the ubiquitin-proteasome pathway based on IAP ligand. SNIPER(TACC3)-1 induces cancer cell death^[1].
分子量	804.01
Formula	C₄₁H₅₇N₉O₆S
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Ohoka N, et al. Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin-proteasome pathway. Cell Death Dis. 2014 Nov 6;5:e1513.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SNIPER(ABL)-058

发表于2024年10月31日由上海金畔生物科技有限公司

SNIPER(ABL)-058

SNIPER(ABL)-058，由 Imatinib (ABL 抑制剂) 通过 linker 与 LCL161 衍生物 (IAP 配体) 组合而成，可有效降解 BCR-ABL 蛋白，DC₅₀ 为 10 μM。

SNIPER(ABL)-058 Chemical Structure

CAS No. : 2222354-61-0

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生物活性	SNIPER(ABL)-058, conjugating Imatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 10 μM^[1].
分子量	1150.39
Formula	C₆₂H₇₅N₁₁O₉S
CAS 号	2222354-61-0
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SNIPER(ABL)-024

发表于2024年10月31日由上海金畔生物科技有限公司

SNIPER(ABL)-024

SNIPER(ABL)-024，由 GNF5 (ABL 抑制剂) 通过 linker 与 LCL161 衍生物 (IAP 配体) 组合而成，可有效降解 BCR-ABL 蛋白，DC₅₀ 为 5μM。

SNIPER(ABL)-024 Chemical Structure

CAS No. : 2222355-77-1

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生物活性	SNIPER(ABL)-024, conjugating GNF5 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 5μM^[1].
分子量	1031.15
Formula	C₅₂H₆₁F₃N₈O₉S
CAS 号	2222355-77-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SNIPER(ABL)-015

发表于2024年10月31日由上海金畔生物科技有限公司

SNIPER(ABL)-015

SNIPER(ABL)-015，由 GNF5 (ABL 抑制剂) 通过 linker 与 MV-1 (IAP 配体) 组合而成，可有效降解 BCR-ABL 蛋白，DC₅₀ 为 5μM。

SNIPER(ABL)-015 Chemical Structure

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生物活性	SNIPER(ABL)-015, conjugating GNF5 (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 5 μM ^[1].
分子量	1094.23
Formula	C₅₈H₇₀F₃N₉O₉
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SNIPER(ABL)-050

发表于2024年10月30日由上海金畔生物科技有限公司

SNIPER(ABL)-050

SNIPER(ABL)-050，由 Imatinib (ABL 抑制剂) 通过 linker 与 MV-1 (IAP 配体) 组合而成，可有效降解 BCR-ABL 蛋白。

SNIPER(ABL)-050 Chemical Structure

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生物活性	SNIPER(ABL)-050, conjugating Imatinib (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein^[1].
分子量	1213.47
Formula	C₆₈H₈₄N₁₂O₉
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SNIPER(ABL)-033

发表于2024年10月30日由上海金畔生物科技有限公司

SNIPER(ABL)-033

SNIPER(ABL)-033，由 HG-7-85-01 (ABL 抑制剂) 通过 linker 与 LCL161 衍生物 (IAP 配体) 组合而成，可有效降解 BCR-ABL 蛋白，DC₅₀ 为 0.3 μM。

SNIPER(ABL)-033 Chemical Structure

CAS No. : 2222354-18-7

规格		是否有货
100 mg		询价
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生物活性	SNIPER(ABL)-033, conjugating HG-7-85-01 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 0.3 μM^[1].
分子量	1211.42
Formula	C₆₁H₇₃F₃N₁₀O₉S₂
CAS 号	2222354-18-7
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SNIPER(ABL)-013

发表于2024年10月30日由上海金畔生物科技有限公司

SNIPER(ABL)-013

SNIPER(ABL)-013，由 GNF5 (ABL 抑制剂) 通过 linker 与 Bestatin (IAP 配体) 组合而成，可有效降解 BCR-ABL 蛋白，DC₅₀ 为 20 μM。

SNIPER(ABL)-013 Chemical Structure

规格		是否有货
100 mg		询价
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生物活性	SNIPER(ABL)-013, conjugating GNF5 (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 20 μM^[1].
分子量	839.90
Formula	C₄₂H₅₂F₃N₇O₈
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SNIPER(ABL)-019

发表于2024年10月30日由上海金畔生物科技有限公司

SNIPER(ABL)-019

SNIPER(ABL)-019，由 Dasatinib (ABL 抑制剂) 通过 linker 与 MV-1 (cIAP1 配体) 组合而成，可有效降解 BCR-ABL 蛋白，DC₅₀ 为 0.3 μM。

SNIPER(ABL)-019 Chemical Structure

规格		是否有货
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生物活性	SNIPER(ABL)-019, conjugating Dasatinib (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 0.3 μM^[1].
分子量	1177.85
Formula	C₆₀H₇₇ClN₁₂O₉S
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SNIPER(ABL)-044

发表于2024年10月30日由上海金畔生物科技有限公司

SNIPER(ABL)-044

SNIPER(ABL)-044，由 HG-7-85-01 (ABL 抑制剂) 通过 linker 与 Bestatin (IAP 配体) 组合而成，可有效降解 BCR-ABL 蛋白，DC₅₀ 为 10 μM。

SNIPER(ABL)-044 Chemical Structure

规格		是否有货
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生物活性	SNIPER(ABL)-044, conjugating HG-7-85-01 (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 10 μM^[1].
分子量	1020.17
Formula	C₅₁H₆₄F₃N₉O₈S
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

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SNIPER(ABL)-049

发表于2024年10月30日由上海金畔生物科技有限公司

SNIPER(ABL)-049

SNIPER(ABL)-049，由 Imatinib (ABL 抑制剂) 通过 linker 与 Bestatin (IAP 配体) 组合而成，可有效降解 BCR-ABL 蛋白，DC₅₀ 为 100 μM。

SNIPER(ABL)-049 Chemical Structure

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生物活性	SNIPER(ABL)-049, conjugating Imatinib (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 100 μM^[1].
分子量	959.14
Formula	C₅₂H₆₆N₁₀O₈
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

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SNIPER(ABL)-039

发表于2024年10月30日由上海金畔生物科技有限公司

SNIPER(ABL)-039

SNIPER(ABL)-039，由 Dasatinib (ABL 抑制剂) 通过 linker 与 LCL161 衍生物 (IAP 配体) 组合而成，可有效降解 BCR-ABL 蛋白，DC₅₀ 为 10 nM。对 ABL，cIAP1，cIAP2，XIAP 的 IC₅₀ 分别为 0.54 nM，10 nM，12 nM 和 50 nM。

SNIPER(ABL)-039 Chemical Structure

CAS No. : 2222354-29-0

规格		是否有货
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250 mg		询价
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生物活性

SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 10 nM. IC₅₀s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively^[1].

IC₅₀ & Target^[1]

Abl

0.54 nM (IC₅₀)

cIAP1

10 nM (IC₅₀)

cIAP2

12 nM (IC₅₀)

XIAP

50 nM (IC₅₀)

SNIPER

Abl

10 nM (DC₅₀)

分子量

1114.77

Formula

C₅₄H₆₈ClN₁₁O₉S₂

CAS 号

2222354-29-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

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SNIPER(ABL)-047

发表于2024年10月29日由上海金畔生物科技有限公司

SNIPER(ABL)-047

SNIPER(ABL)-047，由 HG-7-85-01 (ABL 抑制剂) 通过 linker 与 MV-1 (IAP 配体) 组合而成，可有效降解 BCR-ABL 蛋白，DC₅₀ 为 2 μM。

SNIPER(ABL)-047 Chemical Structure

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性	SNIPER(ABL)-047, conjugating HG-7-85-01 (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 2 μM^[1].
分子量	1274.50
Formula	C₆₇H₈₂F₃N₁₁O₉S
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

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SNIPER(ER)-110

发表于2024年7月31日由上海金畔生物科技有限公司

SNIPER(ER)-110

SNIPER(ER)-110 由 IAP 配体和雌激素配体，通过 linker 连接组成。SNIPER(ER)-110 诱导雌激素受体 (estrogen receptor; ER) 蛋白降解，处理 4 小时和 48 小时后，DC₅₀ 分别为 <3 nM 和 7.7 nM。

SNIPER(ER)-110 Chemical Structure

CAS No. : 2241690-03-7

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生物活性	SNIPER(ER)-110 consists of a IAP ligand and an estrogen ligand, connected by a linker. SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC₅₀s of <3 nm and 7.7 after 4 h 48 h, respectively^[1].
分子量	1122.39
Formula	C₆₆H₈₃N₅O₁₁
CAS 号	2241690-03-7
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Ohoka N, et al. Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation. J Biol Chem. 2018 May 4;293(18):6776-6790.

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SNIPER(ER)-87

发表于2024年7月24日由上海金畔生物科技有限公司

SNIPER(ER)-87

SNIPER(ER)-87 由凋亡蛋白 (IAP) 配体 LCL161 衍生物的抑制剂组成，该抑制剂通过 PEG 接头与雌激素受体 α (ERα) 配体 4-Hydroxytamoxifen 缀合，并有效降解 ERα 蛋白 (IC₅₀=0.097 μM)。SNIPER(ER)-87 在细胞中优先招募 XIAP 至 ERα，而 XIAP 是负责 SNIPER(ER)-87 诱导的 ERα 降解的主要 E3 泛素连接酶。

SNIPER(ER)-87 Chemical Structure

CAS No. : 2222354-91-6

规格		是否有货
100 mg		询价
250 mg		询价
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生物活性	SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC₅₀=0.097 μM). SNIPER(ER)-87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERα degradation^[1]^[2].
体外研究 (In Vitro)	SNIPER(ER)-87 (0.1-1000 nM; 72 hours) efficiently inhibits the ERα-dependent transcriptional activation by β-estradiol and suppresses the growth of ERα-positive breast tumor cells with IC₅₀s of 15.6 nM in MCF-7 and 9.6 nM in T47D cells^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)	SNIPER(ER)-87 (30 mg/kg, i.p., every 24 h for 14 days) inhibits the growth of MCF-7 orthotopic breast tumor xenografts in 6-week-old female BALB/c nude mice^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	1044.30
Formula	C₅₉H₇₃N₅O₁₀S
CAS 号	2222354-91-6
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Ohoka N, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs). J Biol Chem. 2017 Mar 17;292(11):4556-4570. [2]. Ohoka N, et al. Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation. J Biol Chem. 2018 May 4;293(18):6776-6790.

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SNIPER(BRD)-1

发表于2024年7月7日由上海金畔生物科技有限公司

SNIPER(BRD)-1

SNIPER(BRD)-1 由 IAP 拮抗剂 LCL-161 衍生物和 BET 抑制剂 (+)-JQ-1，通过 linker 连接组成。SNIPER(BRD)-1 通过泛素-蛋白酶体系统诱导 BRD4 降解。SNIPER(BRD)-1 也降解 cIAP1，cIAP2 和 XIAP，IC₅₀ 分别为 6.8 nM，17 nM 和 49 nM。

SNIPER(BRD)-1 Chemical Structure

CAS No. : 2095244-54-3

规格	价格	是否有货
1 mg	￥8000	询问价格 & 货期

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生物活性

SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC₅₀s of 6.8 nM, 17 nM, and 49nM, respectively^[1].

IC₅₀ & Target^[1]

BRD4

cIAP1

6.8 nM (IC₅₀)

cIAP2

17 nM (IC₅₀)

XIAP

49 nM (Ki)

SNIPER

分子量

1056.73

Formula

C₅₃H₆₆ClN₉O₈S₂

CAS 号

2095244-54-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据

In Vitro:

DMSO : 100 mg/mL (94.63 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.9463 mL	4.7316 mL	9.4632 mL
5 mM	0.1893 mL	0.9463 mL	1.8926 mL
10 mM	0.0946 mL	0.4732 mL	0.9463 mL

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.5 mg/mL (2.37 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.37 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% corn oil

Solubility: ≥ 2.5 mg/mL (2.37 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (2.37 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Ohoka N, et al. Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER). Chem Pharm Bull (Tokyo). 2019 Mar 1;67(3):203-209.

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whatman (沃特曼)

英国沃特曼 Millipore PALL中国代理商金畔官网

标签归档：sniper

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