标签归档：flurbiprofen

Flurbiprofen-13C,d3(Synonyms: dl-Flurbiprofen-13C,d3)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Flurbiprofen-13C,d3 (Synonyms: dl-Flurbiprofen-13C,d3)

Flurbiprofen-13C,d3 是一种 13C- 和氘代标记的 Flurbiprofen。Flurbiprofen (dl-Flurbiprofen) 是一种高效的，具有口服活性的非甾体抗炎化合物，有退热止痛活性, 常用于炎症性疾病 (包括骨关节炎、类风湿关节炎) 的研究。Flurbiprofen 是一种非选择性的环氧合酶 (COX) 抑制剂，可用于结肠癌的研究。

Flurbiprofen-13C,d3(Synonyms: dl-Flurbiprofen-13C,d3)

Flurbiprofen-13C,d3 Chemical Structure

CAS No. : 2747917-55-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Flurbiprofen-13C,d3 is the 13C- and deuterium labeled. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[64].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

248.27

Formula

C1413CH10D3FO2
CAS 号

2747917-55-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

    [2]. Xiaobo Wang, et al. Flurbiprofen suppresses the inflammation, proliferation, invasion and migration of colorectal cancer cells via COX2. Oncol Lett. 2020 Nov; 20(5): 132.

    [3]. E M Glenn, et al. The pharmacology of 2-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen). A potent non-steroidal anti-inflammatory drug. Agents Actions. 1973 Nov;3(4):210-6.

    [4]. Hosoi, T., et al., Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress. EMBO Mol Med, 2014.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Flurbiprofen-d5(Synonyms: dl-Flurbiprofen-d5)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Flurbiprofen-d5 (Synonyms: dl-Flurbiprofen-d5)

Flurbiprofen-d5 (dl-Flurbiprofen-d5) 是 Flurbiprofen 的氘代物。Flurbiprofen (dl-Flurbiprofen) 是一种高效的，具有口服活性的非甾体抗炎化合物，有退热止痛活性, 常用于炎症性疾病 (包括骨关节炎、类风湿关节炎) 的研究。Flurbiprofen 是一种非选择性的环氧合酶 (COX) 抑制剂，可用于结肠癌的研究。

Flurbiprofen-d5(Synonyms: dl-Flurbiprofen-d5)

Flurbiprofen-d5 Chemical Structure

CAS No. : 215175-76-1

规格 是否有货
1 mg Check price and availability
5 mg Check price and availability
10 mg Check price and availability
50 mg Check price and availability

* Please select Quantity before adding items.

生物活性

Flurbiprofen-d5 (dl-Flurbiprofen-d5) is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

249.29

Formula

C15H8D5FO2
CAS 号

215175-76-1
中文名称

氟比洛芬 d5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Xiaobo Wang, et al. Flurbiprofen suppresses the inflammation, proliferation, invasion and migration of colorectal cancer cells via COX2. Oncol Lett. 2020 Nov; 20(5): 132.

    [3]. E M Glenn, et al. The pharmacology of 2-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen). A potent non-steroidal anti-inflammatory drug. Agents Actions. 1973 Nov;3(4):210-6.

    [4]. Hosoi, T., et al., Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress. EMBO Mol Med, 2014.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Flurbiprofen(Synonyms: 氟比洛芬; dl-Flurbiprofen)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Flurbiprofen (Synonyms: 氟比洛芬; dl-Flurbiprofen) 纯度: 99.85%

Flurbiprofen (dl-Flurbiprofen) 是一种高效的，具有口服活性的非甾体抗炎化合物，有退热止痛活性, 常用于炎症性疾病 (包括骨关节炎、类风湿关节炎) 的研究。Flurbiprofen 是一种非选择性的环氧合酶 (COX) 抑制剂，可用于结肠癌的研究。

Flurbiprofen(Synonyms: 氟比洛芬; dl-Flurbiprofen)

Flurbiprofen Chemical Structure

CAS No. : 5104-49-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥550 In-stock
100 mg ￥500 In-stock
500 mg ￥700 In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

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生物活性

Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].

IC50 & Target[1]

COX

 

COX-1

 

COX-2

 

体外研究
(In Vitro)

Flurbiprofen (2-20 nM; 12-48 hours) significantly decreases SW620 cells proliferation in a concentration- and time-dependent manner[1].
Flurbiprofen (10 nM; 24 hours) decreases COX-2 expression[1].
Flurbiprofen (10 nM; 24 hours) inhibits the expression of inflammatory factors by inhibiting COX-2[1].
Flurbiprofen (10 nM; 24 hours) promotes the apoptosis of colorectal cancer cells by inhibiting COX-2[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: SW620 cells
Concentration: 2 nM, 4 nM, 10 nM, 20 nM
Incubation Time: 12 hours, 24 hours, 48 hours
Result: Inhibited colorectal cancer cell proliferation.

Western Blot Analysis[1]

Cell Line: SW620 cells
Concentration: 10 nM
Incubation Time: 24 hours
Result: Significantly decreased the protein and mRNA levels of COX-2.

RT-PCR[1]

Cell Line: SW620 cells
Concentration: 10 nM
Incubation Time: 24 hours
Result: Decreased COX-2 mRNA expression levels

Apoptosis Analysis[1]

Cell Line: SW620 cells
Concentration: 10 nM
Incubation Time: 24 hours
Result: Significantly decreased the expression of Bcl2 and significantly increased the expression of Bax and cleaved-caspase3, with no effect on total caspase-3.

体内研究
(In Vivo)

Flurbiprofen (0.3-4.8 mg/kg; p.o.; 4-5 dosages) has acute anti-inflammatory in adrenalectomized rats[2].
Flurbiprofen (10 mg/kg; i.p.; daily; for 6 days) attenuates high-fat diet-induced obesity in mice[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[2]
Dosage: 0.3 mg/kg, 0.6 mg/kg, 1.2 mg/kg, 2.4 mg/kg, 4.8 mg/kg
Administration: Oral administration, 4-5 dosages
Result: Inhibited the acute inflammation.

Clinical Trial

分子量

244.26

Formula

C15H13FO2
CAS 号

5104-49-4
中文名称

氟比洛芬；氟联苯丙酸；苯氟布洛芬；氟苯布洛芬；氟布洛芬；氟吡洛芬
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 100 mg/mL (409.40 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.0940 mL 20.4700 mL 40.9400 mL
5 mM 0.8188 mL 4.0940 mL 8.1880 mL
10 mM 0.4094 mL 2.0470 mL 4.0940 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.23 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.23 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.23 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.23 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.23 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (10.23 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Xiaobo Wang, et al. Flurbiprofen suppresses the inflammation, proliferation, invasion and migration of colorectal cancer cells via COX2. Oncol Lett. 2020 Nov; 20(5): 132.

    [2]. E M Glenn, et al. The pharmacology of 2-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen). A potent non-steroidal anti-inflammatory drug. Agents Actions. 1973 Nov;3(4):210-6.

    [3]. Hosoi, T., et al., Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress. EMBO Mol Med, 2014.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Flurbiprofen-d3(Synonyms: dl-Flurbiprofen-d3)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Flurbiprofen-d3 (Synonyms: dl-Flurbiprofen-d3)

Flurbiprofen-d3 (dl-Flurbiprofen-d3) 是 Flurbiprofen 的氘代物。Flurbiprofen (dl-Flurbiprofen) 是一种高效的，具有口服活性的非甾体抗炎化合物，有退热止痛活性, 常用于炎症性疾病 (包括骨关节炎、类风湿关节炎) 的研究。Flurbiprofen 是一种非选择性的环氧合酶 (COX) 抑制剂，可用于结肠癌的研究。

Flurbiprofen-d3(Synonyms: dl-Flurbiprofen-d3)

Flurbiprofen-d3 Chemical Structure

CAS No. : 1185133-81-6

规格 是否有货
5 mg Check price and availability
50 mg Check price and availability

* Please select Quantity before adding items.

生物活性

Flurbiprofen-d3 (dl-Flurbiprofen-d3) is the deuterium labeled Flurbiprofen. Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

247.28

Formula

C15H10D3FO2
CAS 号

1185133-81-6
中文名称

氟比洛芬 d3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Xiaobo Wang, et al. Flurbiprofen suppresses the inflammation, proliferation, invasion and migration of colorectal cancer cells via COX2. Oncol Lett. 2020 Nov; 20(5): 132.

    [3]. E M Glenn, et al. The pharmacology of 2-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen). A potent non-steroidal anti-inflammatory drug. Agents Actions. 1973 Nov;3(4):210-6.

    [4]. Hosoi, T., et al., Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress. EMBO Mol Med, 2014.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务