标签归档：fumaric

Fumaric acid-13C4(Synonyms: 反丁烯二酸 13C4)

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Fumaric acid-13C4 (Synonyms: 反丁烯二酸 13C4)

Fumaric acid-13C4 是一种 13C 标记的 Fumaric acid。Fumaric acid，与烟酸酶缺乏症相关，是癌症引起的内源性代谢物。

Fumaric acid-13C4(Synonyms: 反丁烯二酸 13C4)

Fumaric acid-13C4 Chemical Structure

CAS No. : 201595-62-2

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生物活性

Fumaric acid-13C4 is the 13C-labeled Fumaric acid. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

120.04

Formula

13C4H4O4
CAS 号

201595-62-2
中文名称

反丁烯二酸 13C4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132(3):301-8.

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Fumaric acid(Synonyms: 反丁烯二酸)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Fumaric acid (Synonyms: 反丁烯二酸) 纯度: ≥98.0%

Fumaric acid，与烟酸酶缺乏症相关，是癌症引起的内源性代谢物。

Fumaric acid(Synonyms: 反丁烯二酸)

Fumaric acid Chemical Structure

CAS No. : 110-17-8

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10 mM * 1 mL in DMSO ￥550 In-stock
100 mg ￥500 In-stock
200 mg   询价  
500 mg   询价  

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Fumaric acid 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • FDA-Approved Drug Library Mini
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  • Anti-Cancer Compound Library
  • Human Endogenous Metabolite Compound Library
  • Drug Repurposing Compound Library
  • NMPA-Approved Drug Library
  • Medicine Food Homology Compound Library
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  • FDA Approved & Pharmacopeial Drug Library
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生物活性

Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite.

IC50 & Target

Human Endogenous Metabolite

 

Clinical Trial

分子量

116.07

Formula

C4H4O4
CAS 号

110-17-8
中文名称

反丁烯二酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 25 mg/mL (215.39 mM; Need ultrasonic)

H2O : 11.11 mg/mL (95.72 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 8.6155 mL 43.0775 mL 86.1549 mL
5 mM 1.7231 mL 8.6155 mL 17.2310 mL
10 mM 0.8615 mL 4.3077 mL 8.6155 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132(3):301-8.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务