磷酸四环素复合物

磷酸四环素复合物是由金黄色链霉菌产生的广谱抗生素，可用于一系列生物测定。抗生素通过与微生物核糖体的30S核糖体亚基结合而起作用，通过阻断带电的氨酰基-tRNA的附着来抑制蛋白质合成。另外，研究表明，去除抗生素后，四环磷酸酯复合物的作用是可逆的。但是，一旦磷酸四环素复合物进入细胞环境，它就不会轻易离开。此外，耐药细胞不允许抗生素进入细胞，或者它们能够在浓度达到毒性水平之前将抗生素从细胞中排出。或者，由于四环素可以被骨组织吸收并使用荧光标记，因此四环素磷酸酯复合物可作为骨生长和估计骨重吸收率的标志物。

Tetracycline phosphate complex is a broad spectrum antibiotic produced by|Streptomyces aureofaciens|that is useful in an array of bioassays. The antibiotic functions by binding to the 30S ribosomal subunit of microbial ribosomes inhibiting protein synthesis via blocking the attachment of charged aminoacyl-tRNA. In addition, studies suggest that the effects of Tetracycline phosphate complex are reversible upon removal of the antibiotic. However once Tetracycline phosphate complex has entered the cellular environment it does not readily leave. Furthermore, resistant cells either do not allow the antibiotic entry into the cell or they are able to eject the antibiotic out of the cell before the concentration reaches toxic levels. Alternatively, Tetracycline phosphate complex functions as a marker for bone growth and estimating bone reabsorption rates, since Tetracycline can be absorbed by bone tissue and tagged using fluorescence.

弗吉尼亚霉素复合物

弗吉尼亚霉素复合物是75％维吉尼亚霉素M1（维吉尼霉素 A，sc-202269）和25％维吉尼亚霉素S1的固体粉末混合物，两种链霉菌素抗生素具有协同杀菌作用。弗吉尼亚霉素M1抑制50S核糖体亚基的功能，而不会阻止其组装，从而产生抑菌作用。加入维吉尼亚霉素S1成分后，弗吉尼亚霉素复合物具有杀菌作用，表明这两种化合物与核糖体缔合后会发生相互作用。如果将弗吉尼亚霉素复合物用于牲畜，可能会改善生长。弗吉尼亚霉素复合物可以控制细菌与燃料乙醇发酵罐中的酵母竞争。

Virginiamycin Complex is a solid powder mixture of 75% virginiamycin M1 (Ostreogrycin A, sc-202269) and 25% virginiamycin S1, two streptogramin antibiotics which present a synergistic bacteriocidal action. Virginiamycin M1 inhibits the function of the 50S ribosomal subunit without blocking its assembly, producing a bacteriostatic effect. With the addition of the virginiamycin S1 component, the Virginiamycin Complex presents bacteriocidal effects, indicating an interaction between the two compounds upon their association with the ribosome. Virginiamycin Complex, when given to livestock, may improve growth. Virginiamycin Complex can control bacteria competing with yeast in fuel ethanol fermenters.