标签归档：indotecan

Indotecan(Synonyms: LMP-400; NSC-724998)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Indotecan (Synonyms: LMP-400; NSC-724998) 纯度: ≥98.0%

Indotecan (LMP-400) 是一种有效的 topoisomerase 1(Top1) 抑制剂。Indotecan (LMP-400) 对 P388, HCT116, MCF-7 细胞系的IC50 值分别为 300, 1200, 560 nM。

Indotecan(Synonyms: LMP-400; NSC-724998)

Indotecan Chemical Structure

CAS No. : 915303-09-2

规格 价格 是否有货 数量
1 mg ￥800 In-stock
5 mg ￥1600 In-stock
10 mg ￥2700 In-stock
25 mg ￥4900 In-stock
50 mg ￥8100 In-stock
100 mg   询价  
200 mg   询价  

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Indotecan 相关产品

•相关化合物库:

  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus

生物活性

Indotecan (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively.

IC50 & Target

IC50：300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively[1].
Clinical Trial

分子量

478.49

Formula

C26H26N2O7
CAS 号

915303-09-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶解性数据
In Vitro: 

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)
参考文献

  • [1]. Seol Y, et al. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors. Mol Cancer Ther. 2015 Nov;14(11):2552-9.

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