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ITK inhibitor 6
ITK inhibitor 6 (compound 43) 是一种有效的选择性 ITK 抑制剂,ITK、BTK、JAK3、EGFR、LCK 的 IC50s 分别为 4 nM、133 nM、320 nM、2360 nM、155 nM。ITK inhibitor 6 抑制 PLCγ1 和 ERK1/2 的磷酸化。ITK inhibitor 6 具有抗增殖活性。
ITK inhibitor 6 Chemical Structure
CAS No. : 2404604-06-2
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是否有货 |
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100 mg |
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250 mg |
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500 mg |
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* Please select Quantity before adding items.
生物活性 |
ITK inhibitor 6 (compound 43) is a potent and selective ITK inhibitor with IC50s of 4 nM, 133 nM, 320 nM, 2360 nM, 155 nM for ITK, BTK, JAK3, EGFR, LCK, respectively. ITK inhibitor 6 inhibits phosphorylation of PLCγ1 and ERK1/2. ITK inhibitor 6 shows antiproliferative activities[1].
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IC50 & Target |
IC50: 4 nM (ITK); 133 nM (BTK), 320 nM (JAK3), 2360 nM (EGFR), 155 nM (LCK)[1]
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体外研究 (In Vitro) |
ITK inhibitor 6 (compound 43) shows antiproliferative activities with GI50s of 5.1, 3.7, 3.4, 5.4, 19 µM for Jurkat, Molt-4, CCRF-CEM, H9, HEK 293 T cells, respectively[1]. ITK inhibitor 6 docks into the ATP-binding site of ITK and BTK[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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运输条件 |
Room temperature in continental US; may vary elsewhere.
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis.
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参考文献 |
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[1]. Wang X, et al. Design, synthesis and structure-activity relationship of indolylindazoles as potent and selective covalent inhibitors of interleukin-2 inducible T-cell kinase (ITK). Eur J Med Chem. 2020 Feb 1;187:111918.
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