KRAS G12D inhibitor 6

发表于2023年12月13日由上海金畔生物科技有限公司

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

KRAS G12D inhibitor 6

KRAS G12D inhibitor 6 是 KRAS G12D 的有效抑制剂 (信息来自专利 WO2021108683A1，compound 112)。

KRAS G12D inhibitor 6 Chemical Structure

CAS No. : 2648552-32-1

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生物活性	KRAS G12D inhibitor 6 is a potent inhibitor of KRAS G12D (extracted from patent WO2021108683A1, compound 112) ^[1].
IC₅₀ & Target	KRAS G12D^[1]
分子量	601.14
Formula	C₃₂H₃₇ClN₈O₂
CAS 号	2648552-32-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. PITZEN, Jennifer, et al. COVALENT RAS INHIBITORS AND USES THEREOF. Patent WO2021108683A1.

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KRAS G12D inhibitor 7

发表于2023年12月13日由上海金畔生物科技有限公司

KRAS G12D inhibitor 7

KRAS G12D inhibitor 7 是 KRAS G12D 的有效抑制剂 (信息来自专利 WO2021108683，compound 114)。

KRAS G12D inhibitor 7 Chemical Structure

CAS No. : 2648552-34-3

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生物活性

KRAS G12D inhibitor 7 is a potent inhibitor of KRAS G12D (extracted from patent WO2021108683, compound 114) ^[1].

IC₅₀ & Target

KRas G12D

分子量

582.70

Formula

C₃₂H₃₈N₈O₃

CAS 号

2648552-34-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. PITZEN, Jennifer, et al. COVALENT RAS INHIBITORS AND USES THEREOF. Patent WO2021108683A1.

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KRAS G12D inhibitor 6

发表于2023年12月13日由上海金畔生物科技有限公司

KRAS G12D inhibitor 6

KRAS G12D inhibitor 6 是 KRAS G12D 的有效抑制剂 (信息来自专利 WO2021108683A1，compound 112)。

KRAS G12D inhibitor 6 Chemical Structure

CAS No. : 2648552-32-1

规格		是否有货
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生物活性	KRAS G12D inhibitor 6 is a potent inhibitor of KRAS G12D (extracted from patent WO2021108683A1, compound 112) ^[1].
IC₅₀ & Target	KRAS G12D^[1]
分子量	601.14
Formula	C₃₂H₃₇ClN₈O₂
CAS 号	2648552-32-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. PITZEN, Jennifer, et al. COVALENT RAS INHIBITORS AND USES THEREOF. Patent WO2021108683A1.

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KRAS G12D inhibitor 7

发表于2023年12月13日由上海金畔生物科技有限公司

KRAS G12D inhibitor 7

KRAS G12D inhibitor 7 是 KRAS G12D 的有效抑制剂 (信息来自专利 WO2021108683，compound 114)。

KRAS G12D inhibitor 7 Chemical Structure

CAS No. : 2648552-34-3

规格		是否有货
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生物活性

KRAS G12D inhibitor 7 is a potent inhibitor of KRAS G12D (extracted from patent WO2021108683, compound 114) ^[1].

IC₅₀ & Target

KRas G12D

分子量

582.70

Formula

C₃₂H₃₈N₈O₃

CAS 号

2648552-34-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. PITZEN, Jennifer, et al. COVALENT RAS INHIBITORS AND USES THEREOF. Patent WO2021108683A1.

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KRAS inhibitor-14

发表于2023年12月10日由上海金畔生物科技有限公司

KRAS inhibitor-14

KRAS inhibitor-14 (compound 3-22) 是一种有效的 KRAS G12C 抑制剂，IC₅₀ 为 0.249 µM。KRAS inhibitor-14 在 MIA PaCA-2，A549 细胞中显示出 p-ERK 抑制活性，IC₅₀s 分别为 1.12，>33.3 µM。KRAS inhibitor-14 具有研究胰腺癌，结直肠癌和肺癌的潜力。

KRAS inhibitor-14 Chemical Structure

CAS No. : 2230873-78-4

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生物活性

KRAS inhibitor-14 (compound 3-22) is a potent KRAS G12C inhibitor with an IC₅₀ of 0.249 µM. KRAS inhibitor-14 shows p-ERK inhibition activities with IC₅₀s of 1.12, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-14 has the potential for the research of pancreatic, colorectal, and lung cancers^[1].

IC₅₀ & Target^[1]

KRas G12C

0.249 μM (IC₅₀)

分子量

486.77

Formula

C₂₀H₁₅Cl₃FN₃O₂S

CAS 号

2230873-78-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2

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KRAS inhibitor-16

发表于2023年12月10日由上海金畔生物科技有限公司

KRAS inhibitor-16

KRAS inhibitor-16 (compound 3-11) 是一种有效的 KRAS G12C 抑制剂，IC₅₀ 为 0.457 µM。KRAS inhibitor-16 在 MIA PaCA-2，A549 细胞中显示出 p-ERK 抑制活性，IC₅₀s 分别为 3.06，11.1 µM。 KRAS inhibitor-16 具有研究胰腺癌，结直肠癌和肺癌的潜力。

KRAS inhibitor-16 Chemical Structure

CAS No. : 2230873-67-1

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生物活性

KRAS inhibitor-16 (compound 3-11) is a potent KRAS G12C inhibitor with an IC₅₀ of 0.457 µM. KRAS inhibitor-16 shows p-ERK inhibition activities with IC₅₀s of 3.06, 11.1 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-16 has the potential for the research of pancreatic, colorectal, and lung cancers^[1].

IC₅₀ & Target

KRas G12C

0.457 μM (IC₅₀)

分子量

452.33

Formula

C₂₀H₁₆Cl₂FN₃O₂S

CAS 号

2230873-67-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Brian Alan LANMAN, et al. Kras g12c inhibitors and methods of using the same. US20180334454A1.

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KRAS G12C inhibitor 43

发表于2023年12月9日由上海金畔生物科技有限公司

KRAS G12C inhibitor 43

KRAS G12C inhibitor 43 (compound 59) 是一种有效 KRAS G12C 抑制剂。KRAS G12C inhibitor 43 对 H358, A549, HCC 细胞具有抗迁移和抗增殖活性，IC₅₀s 分别为 0.001-1 µM, >1 µM, >1 µM。

KRAS G12C inhibitor 43 Chemical Structure

CAS No. : 2648808-69-7

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生物活性

KRAS G12C inhibitor 43 (compound 59) is a potent KRAS G12C inhibitor. KRAS G12C inhibitor 43 shows antimigration and anti-proliferative activity with IC₅₀s of 0.001-1 µM, >1 µM, >1 µM for H358, A549, HCC cells ,respectively^[1].

IC₅₀ & Target^[1]

KRas G12C

分子量

577.68

Formula

C₃₃H₃₅N₇O₃

CAS 号

2648808-69-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Xu Wei, et al. Pyridopyrimidine kras g12c mutant protein inhibitor. WO2021139678A1.

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KRAS G12C inhibitor 44

发表于2023年12月9日由上海金畔生物科技有限公司

KRAS G12C inhibitor 44

KRAS G12C inhibitor 44 (compound 54) 是一种有效且具有口服活性的 KRAS G12C 抑制剂。KRAS G12C inhibitor 44 在 MIA PaCA-2、H358 细胞中显示出抗增殖活性，IC₅₀s 分别为 0.016，0.028 µM。KRAS G12C inhibitor 44 在体内显示出抗肿瘤作用。

KRAS G12C inhibitor 44 Chemical Structure

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生物活性

KRAS G12C inhibitor 44 (compound 54) is a potent and orally active KRAS G12C inhibitor. KRAS G12C inhibitor 44 shows anti-proliferation activities with IC₅₀s of 0.016, 0.028 µM in MIA PaCA-2, H358 cells, respectively. KRAS G12C inhibitor 44 shows antitumor effects in vivo^[1].

IC₅₀ & Target^[1]

KRas G12C

分子量

579.11

Formula

C₃₁H₃₆ClFN₆O₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Li Chao, et al. Spirocyclic tetrahydroquinazolines. WO2021139748A1.

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KRAS G12C inhibitor 45

发表于2023年12月9日由上海金畔生物科技有限公司

KRAS G12C inhibitor 45

KRAS G12C inhibitor 45 (compound 78) 是一种有效的 KRAS G12C 抑制剂。

KRAS G12C inhibitor 45 Chemical Structure

CAS No. : 2670380-74-0

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生物活性

KRAS G12C inhibitor 45 (compound 78) is a potent KRAS G12C inhibitor^[1].

IC₅₀ & Target^[1]

KRas G12C

分子量

637.70

Formula

C₃₂H₃₃F₂N₅O₅S

CAS 号

2670380-74-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. LV Binhua, et al. Aryl or heteroaryl pyridone or pyrimidine derivative preparation method and use thereof. WO2021143693A1.

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KRAS G12C inhibitor 46

发表于2023年12月9日由上海金畔生物科技有限公司

KRAS G12C inhibitor 46

KRAS G12C inhibitor 46 (compound WX003) 是一种有效的 KRAS G12C 抑制剂。

KRAS G12C inhibitor 46 Chemical Structure

CAS No. : 2573769-23-8

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生物活性

KRAS G12C inhibitor 46 (compound WX003) is a potent KRAS G12C inhibitor^[1].

IC₅₀ & Target^[1]

KRas G12C

分子量

585.65

Formula

C₃₂H₃₃F₂N₇O₂

CAS 号

2573769-23-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Li Qiu, et al. Macrocyclic compoung serving as Kras inhibitor. WO2021147967A1.

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KRAS G12C inhibitor 47

发表于2023年12月9日由上海金畔生物科技有限公司

KRAS G12C inhibitor 47

KRAS G12C inhibitor 47 (compound 8-1-1) 是一种有效的 KRAS G12C 抑制剂，IC₅₀ 为 0.172 µM。KRAS G12C inhibitor 47 在 MIA PaCA-2，A549 细胞中显示出 p-ERK 抑制活性，IC₅₀s 分别为 0.046，69.8 µM。KRAS G12C inhibitor 47 具有研究胰腺癌，结直肠癌和肺癌的潜力。

KRAS G12C inhibitor 47 Chemical Structure

CAS No. : 2253119-24-1

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生物活性

KRAS G12C inhibitor 47 (compound 8-1-1) is a potent KRAS G12C inhibitor with an IC₅₀ of 0.172 µM. KRAS G12C inhibitor 47 shows p-ERK inhibition activities with IC₅₀s of 0.046, 69.8 µM in MIA PaCA-2, A549 cells, respectively. KRAS G12C inhibitor 47 has the potential for the research of pancreatic, colorectal, and lung cancers^[1].

IC₅₀ & Target^[1]

KRas G12C

0.172 μM (IC₅₀)

分子量

547.02

Formula

C₃₀H₂₈ClFN₄O₃

CAS 号

2253119-24-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2

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KRAS G12C inhibitor 48

发表于2023年12月9日由上海金畔生物科技有限公司

KRAS G12C inhibitor 48

KRAS G12C inhibitor 48 (compound 6e) 是一种有效的 KRAS G12C 抑制剂，IC₅₀ 为 639.91 nM。 KRAS G12C inhibitor 48 (0-50 µM) 具有抗增殖活性，对 H358，H23，A549 细胞的 IC₅₀s 分别为 0.796，6.33，16.14 µM.

KRAS G12C inhibitor 48 Chemical Structure

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生物活性

KRAS G12C inhibitor 48 (compound 6e) is a potent KRAS G12C inhibitor with an IC₅₀ of 639.91 nM. KRAS G12C inhibitor 48 (0-50 µM) shows anti-proliferative activity with IC₅₀s of 0.796, 6.33, 16.14 µM for H358, H23, A549 cells, respectively^[1].

IC₅₀ & Target

KRas G12C

639.91 nM (IC₅₀)

分子量

651.20

Formula

C₃₆H₃₉ClN₈O₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Yang F, et al. Efficient targeted oncogenic KRASG12C degradation via first reversible-covalent PROTAC. Eur J Med Chem. 2022 Feb 15;230:114088.

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KRAS inhibitor-12

发表于2023年12月9日由上海金畔生物科技有限公司

KRAS inhibitor-12

KRAS inhibitor-12 (compound 6-1) 是一种有效的 KRAS G12C 抑制剂，IC₅₀ 为 0.537 µM。KRAS inhibitor-12 在 MIA PaCA-2，A549 细胞中显示出 p-ERK 抑制活性，IC₅₀s 分别为 1.3，3.7 µM。 KRAS inhibitor-12 具有研究胰腺癌，结直肠癌和肺癌的潜力。

KRAS inhibitor-12 Chemical Structure

CAS No. : 2230874-00-5

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生物活性

KRAS inhibitor-12 (compound 6-1) is a potent KRAS G12C inhibitor with an IC₅₀ of 0.537 µM. KRAS inhibitor-12 shows p-ERK inhibition activities with IC₅₀s of 1.3, 3.7 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-12 has the potential for the research of pancreatic, colorectal, and lung cancers^[1].

IC₅₀ & Target^[1]

KRas G12C

0.537 μM (IC₅₀)

分子量

452.33

Formula

C₁₉H₁₆Cl₂FN₅OS

CAS 号

2230874-00-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2

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KRAS inhibitor-13

发表于2023年12月9日由上海金畔生物科技有限公司

KRAS inhibitor-13

KRAS inhibitor-13 (compound 5-6) 是一种有效的 KRAS G12C 抑制剂，IC₅₀ 为 0.883 µM。KRAS inhibitor-13 在 MIA PaCA-2，A549 细胞中显示出 p-ERK 抑制活性，IC₅₀s 分别为 5.9，>100 µM。 KRAS inhibitor-13具有研究胰腺癌，结直肠癌和肺癌的潜力。

KRAS inhibitor-13 Chemical Structure

CAS No. : 2230873-96-6

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生物活性

KRAS inhibitor-13 (compound 5-6) is a potent KRAS G12C inhibitor with an IC₅₀ of 0.883 µM. KRAS inhibitor-13 shows p-ERK inhibition activities with IC₅₀s of 5.9, >100 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-13 has the potential for the research of pancreatic, colorectal, and lung cancers^[1].

IC₅₀ & Target^[1]

KRas G12C

0.883 μM (IC₅₀)

分子量

479.95

Formula

C₂₅H₁₉ClFN₃O₂S

CAS 号

2230873-96-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2

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KRAS inhibitor-15

发表于2023年12月8日由上海金畔生物科技有限公司

KRAS inhibitor-15

KRAS inhibitor-15 (compound 3-19) 是一种有效的 KRAS G12C 抑制剂，IC₅₀ 为 0.954 µM。KRAS inhibitor-15 在 MIA PaCA-2，A549 细胞中显示出 p-ERK 抑制活性，IC₅₀s 分别为 2.03，>33.3 µM。KRAS inhibitor-15 具有研究胰腺癌，结直肠癌和肺癌的潜力

KRAS inhibitor-15 Chemical Structure

CAS No. : 2230873-75-1

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生物活性

KRAS inhibitor-15 (compound 3-19) is a potent KRAS G12C inhibitor with an IC₅₀ of 0.954 µM. KRAS inhibitor-15 shows p-ERK inhibition activities with IC₅₀s of 2.03, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-15 has the potential for the research of pancreatic, colorectal, and lung cancers^[1].

IC₅₀ & Target^[1]

KRas G12C

0.954 μM (IC₅₀)

分子量

451.34

Formula

C₂₀H₁₇Cl₂FN₄OS

CAS 号

2230873-75-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2

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KRAS inhibitor-17

发表于2023年12月8日由上海金畔生物科技有限公司

KRAS inhibitor-17

KRAS inhibitor-17 (compound 3-9) 是一种有效的 KRAS G12C 抑制剂，IC₅₀ 为 3.37 µM。KRAS inhibitor-17 在 MIA PaCA-2，A549 细胞中的显示 p-ERK 抑制活性，IC₅₀s 分别为 9.25，>33.3 µM。KRAS inhibitor-17 具有研究胰腺癌，结直肠癌和肺癌的潜力。

KRAS inhibitor-17 Chemical Structure

CAS No. : 2230873-65-9

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生物活性

KRAS inhibitor-17 (compound 3-9) is a potent KRAS G12C inhibitor with an IC₅₀ of 3.37 µM. KRAS inhibitor-17 shows p-ERK inhibition activities with IC₅₀s of 9.25, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-17 has the potential for the research of pancreatic, colorectal, and lung cancers^[1].

IC₅₀ & Target^[1]

KRas G12C

3.37 μM (IC₅₀)

分子量

466.36

Formula

C₂₁H₁₈Cl₂FN₃O₂S

CAS 号

2230873-65-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2

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KRAS inhibitor-18

发表于2023年12月8日由上海金畔生物科技有限公司

KRAS inhibitor-18

KRAS inhibitor-18 (compound 3-10) 是一种有效的 KRAS G12C 抑制剂，IC₅₀ 为 4.74 µM。KRAS inhibitor-18 在 MIA PaCA-2，A549 细胞中显示出 p-ERK 抑制活性，IC₅₀s 分别为 66.4，11.1 µM。KRAS inhibitor-18 具有研究胰腺癌，结直肠癌和肺癌的潜力。

KRAS inhibitor-18 Chemical Structure

CAS No. : 2230873-66-0

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生物活性

KRAS inhibitor-18 (compound 3-10) is a potent KRAS G12C inhibitor with an IC₅₀ of 4.74 µM. KRAS inhibitor-18 shows p-ERK inhibition activities with IC₅₀s of 66.4, 11.1 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-18 has the potential for the research of pancreatic, colorectal, and lung cancers^[1].

IC₅₀ & Target^[1]

KRas G12C

4.74 μM (IC₅₀)

分子量

453.87

Formula

C₂₀H₁₅ClF₃N₃O₂S

CAS 号

2230873-66-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2

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KRAS G12C inhibitor 20

发表于2023年12月5日由上海金畔生物科技有限公司

KRAS G12C inhibitor 20

KRAS G12C inhibitor 20 是一种 KRAS G12C 的抑制剂，详细信息请参考专利文献 CN112694475A 中的实施例 1。

KRAS G12C inhibitor 20 Chemical Structure

CAS No. : 2640858-10-0

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250 mg		询价
500 mg		询价

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生物活性	KRAS G12C inhibitor 20 is a KRAS G12C inhibitor extracted from patent CN112694475A, example 1^[1].
IC₅₀ & Target	KRAS G12C^[1]
分子量	634.14
Formula	C₃₃H₃₇ClFN₇O₃
CAS 号	2640858-10-0
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Cycloalkyl and heterocycloalkyl inhibitors, and preparation method and application thereof. CN112694475A.

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KRAS G12C inhibitor 21

发表于2023年12月5日由上海金畔生物科技有限公司

KRAS G12C inhibitor 21

KRAS G12C inhibitor 21 是一种 KRAS G12C 的抑制剂，详细信息请参考专利文献 WO2021219090A1 中的实施例 7。

KRAS G12C inhibitor 21 Chemical Structure

CAS No. : 2737269-61-1

规格		是否有货
100 mg		询价
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生物活性	KRAS G12C inhibitor 21 is a KRAS G12C inhibitor extracted from patent WO2021219090A1, example 7^[1].
IC₅₀ & Target	KRAS G12C^[1]
分子量	580.07
Formula	C₃₄H₃₀ClN₃O₄
CAS 号	2737269-61-1
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Quinoxaline dione derivative as irreversible inhibitor of kras g12c mutant protein. WO2021219090A1.

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KRAS G12C inhibitor 22

发表于2023年12月5日由上海金畔生物科技有限公司

KRAS G12C inhibitor 22

KRAS G12C inhibitor 22 是一种 KRAS G12C 的抑制剂，详细信息请参考专利文献 WO2021219072A1 中的实施例 120。

KRAS G12C inhibitor 22 Chemical Structure

CAS No. : 2736599-72-5

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性	KRAS G12C inhibitor 22 is a KRAS G12C inhibitor extracted from patent WO2021219072A1, example 120^[1].
IC₅₀ & Target	KRAS G12C^[1]
分子量	555.71
Formula	C₃₂H₄₁N₇O₂
CAS 号	2736599-72-5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Preparation and application method of heterocyclic compound as kras inhibitor. WO2021219072A1.

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标签归档：kras

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KRAS G12C inhibitor 43

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