德国耶拿总有机碳/总氮分析仪multi N/C 3100 TOC

德国耶拿总有机碳/总氮分析仪multi N/C 3100 TOC

  • 品牌 耶拿|analytikjena
  • 型号 multi N/C® 3100 TOC
  • 商品详情

    德国耶拿几十年来不断推出引领技术潮流的总量分析和元素分析仪器。凭借可追朔到19世纪的分析仪器制造传统,以及从不停歇的创新脚步,  德国耶拿2010年又推出了multi N/C ®系列全新升级产品。基于多项创新的专利,multi N/C ®系列产品与您分享更加专业、可靠的分析技术。 

     

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  • Multi-kinase inhibitor 1

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Multi-kinase inhibitor 1 

    Multi-kinase inhibitor 1 是一种有效的多激酶 (multi-kinase) 抑制剂。Multi-kinase inhibitor 1 有用于导致与酪氨酸激酶活性异常或失控有关的疾病或失调的潜力,特别是与 PDGF-Rc-KitBcr-abl 活性相关的疾病。

    Multi-kinase inhibitor 1

    Multi-kinase inhibitor 1 Chemical Structure

    CAS No. : 778274-97-8

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Multi-kinase inhibitor 1 is a potent multi-kinase inhibitor. Multi-kinase inhibitor 1 has the potential for diseases or disorders associated with abnormal or deregulated tyrosine kinase activity, particularly diseases associated with the activity of PDGF-R, c-Kit and Bcr-abl[1].

    IC50 & Target[1]

    PDGFR

     

    Bcr-Abl

     

    体外研究
    (In Vitro)

    Multi-kinase inhibitor 1 (compound 68) is a potent multi-kinase inhibitor. The protein kinases represent a large family of proteins, which play a central role in the regulation of a wide variety of cellular processes and maintaining control over cellular function. These kinases include receptor tyrosine kinases, such as platelet derived growth factor receptor kinase(PDGF-R), the receptor kinase for stem cell factor, c-Kit, and non-receptor tyrosine kinases, such as the fusion kinase Bcr-abl[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    418.37

    Formula

    C20H17F3N4O3

    CAS 号

    778274-97-8

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. Qiang Ding, et al. Novel compounds and compositions as protein kinase inhibitors. WO2004089286A2.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    Multi-kinase inhibitor 1

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Multi-kinase inhibitor 1 

    Multi-kinase inhibitor 1 是一种有效的多激酶 (multi-kinase) 抑制剂。Multi-kinase inhibitor 1 有用于导致与酪氨酸激酶活性异常或失控有关的疾病或失调的潜力,特别是与 PDGF-Rc-KitBcr-abl 活性相关的疾病。

    Multi-kinase inhibitor 1

    Multi-kinase inhibitor 1 Chemical Structure

    CAS No. : 778274-97-8

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Multi-kinase inhibitor 1 is a potent multi-kinase inhibitor. Multi-kinase inhibitor 1 has the potential for diseases or disorders associated with abnormal or deregulated tyrosine kinase activity, particularly diseases associated with the activity of PDGF-R, c-Kit and Bcr-abl[1].

    IC50 & Target[1]

    PDGFR

     

    Bcr-Abl

     

    体外研究
    (In Vitro)

    Multi-kinase inhibitor 1 (compound 68) is a potent multi-kinase inhibitor. The protein kinases represent a large family of proteins, which play a central role in the regulation of a wide variety of cellular processes and maintaining control over cellular function. These kinases include receptor tyrosine kinases, such as platelet derived growth factor receptor kinase(PDGF-R), the receptor kinase for stem cell factor, c-Kit, and non-receptor tyrosine kinases, such as the fusion kinase Bcr-abl[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    418.37

    Formula

    C20H17F3N4O3

    CAS 号

    778274-97-8

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. Qiang Ding, et al. Novel compounds and compositions as protein kinase inhibitors. WO2004089286A2.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    Multi-kinase-IN-1

    上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

    Multi-kinase-IN-1 

    Multi-kinase-IN-1 (Compound 11k) 是一种具有抗肿瘤活性的激酶 (kinase) 抑制剂。Multi-kinase-IN-1 诱导细胞凋亡 (apoptosis),可用于结直肠癌 (colorectal cancer) 的研究。

    Multi-kinase-IN-1

    Multi-kinase-IN-1 Chemical Structure

    CAS No. : 2470807-67-9

    规格 是否有货
    100 mg   询价  
    250 mg   询价  
    500 mg   询价  

    * Please select Quantity before adding items.

    生物活性

    Multi-kinase-IN-1 (Compound 11k) is a potent kinase inhibitor with antitumor activity. Multi-kinase-IN-1 induces cell apoptosis, and can be studied for colorectal cancer[1].

    IC50 & Target

    c-Met

    0.382 μM (IC50)

    PDGFRα

    0.384 μM (IC50)

    Ron

    0.122 μM (IC50)

    c-Src

    0.421 μM (IC50)

    AXL

    0.632 μM (IC50)

    体外研究
    (In Vitro)

    Multi-kinase-IN-1 (Compound 11k) (0-5 µg/mL, 0-72 h) induces antiproliferation and cytotoxicity in a dose- and time-dependent manner in HT-29 cells, and is much less toxic to normal colorectal mucosa epithelial cells[1].
    Multi-kinase-IN-1 (0-3 µg/mL, 0-72 h) induces cell apoptosis in a time- and dose-dependent manner[1].
    Multi-kinase-IN-1 (0-3 µg/mL, 48 h) slightly induces cell cycle arrest in G2/M phase[1].

    Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Proliferation Assay[1]

    Cell Line: HT-29 (human colon cancer cell) and FHC (normal colorectal mucosa epithelial cells)
    Concentration: 0.56, 1.67, and 5 µg/mL for HT-29, 10 µg/mL for FHC
    Incubation Time: 0-72 h
    Result: Led to significant cytotoxicity in a dose- and time-dependent manner in HT-29 cells. Showed low toxicity in FHC cells.

    Apoptosis Analysis[1]

    Cell Line: HT-29
    Concentration: 0.3, 1, and 3 µg/mL
    Incubation Time: 0-72 h
    Result: Induced cell apoptosis in a time- and dose-dependent manner.

    Cell Cycle Analysis[1]

    Cell Line: HT-29
    Concentration: 0.3, 1, and 3 µg/mL
    Incubation Time: 48 h
    Result: Slightly induced cell cycle arrest with a G2/M percentage of 4.4% at 3.0 mg/mL compared to 0.1% DMSO (2.4%).

    分子量

    706.76

    Formula

    C35H36F2N6O6S

    CAS 号

    2470807-67-9

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    参考文献
    • [1]. Yuting Zhou, et al. Identification of novel quinoline analogues bearing thiazolidinones as potent kinase inhibitors for the treatment of colorectal cancer. Eur J Med Chem. 2020 Oct 15;204:112643.

    所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

    手动多道移液器MicroPette Multi-channel

    【简单介绍】

    大龙手动多道移液器MicroPette Multi-channel,量程范围广(0.1ul-5000ul);使用附件工具,能方便快捷进行校准和维修。轻便且设计符合人机工效学,可以半支高温高压消毒。

    【详细说明】

    大龙手动多道移液器MicroPette Multi-channel

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    MicroPette Multi-channel

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    • 与大多数品牌管嘴兼容。

    大龙手动多道移液器MicroPette Multi-channel

     MicroPette手动8道可调式移液器

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    7030203004 0.5-10μl
    7030203006 5-50μl
    7030203012 50-300μl

    MicroPette手动12道可调式移液器

    产品编号 量程
    7030204004 0.5-10μl
    7030204006 5-50μl
    7030204012 50-300μl

    大龙手动多道移液器MicroPette Multi-channel