SGN-2FF is a potent and orally active inhibitor of fucosylation, directly inhibits fucosyltransferase activity. SGN-2FF possesses antitumor activity^[1].

Fucosyltransferase^[1]

SGN-2FF (2-Fluorofucose) is an inhibitor of fucosylation, inhibits cellular fucosylation by depleting the fucosylation substrate GDP-fucose, and by direct inhibition of fucosyltransferases, and leads to the production of afucosylated glycoproteins including antibodies. SGN-2FF activates human T cells in an antigen-dependent manner^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SGN-2FF exhibits antitumor activity in multiple mouse tumor models, showing substantial tumor growth delay. SGN-2FF elevates the protective effect of a lymphoma vaccine in a syngeneic mouse model^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

166.15

C₆H₁₁FO₄

2089647-47-0

Room temperature in continental US; may vary elsewhere.

DMSO : 50 mg/mL (300.93 mM; Need ultrasonic)

H₂O : 36.67 mg/mL (220.70 mM; Need ultrasonic)

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储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

• [1]. Stephen C. Alley, et al. Abstract DDT02-02: SGN-2FF: A novel small molecule inhibitor of fucosylation with preclinical antitumor activity through multiple immune mechanisms. Cancer Res 2017;77(13 Suppl).