标签归档：询价

SMYD3-IN-1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SMYD3-IN-1 

SMYD3-IN-1 (compound 29) 是一种不可逆的、选择性的SMYD3 的抑制剂，其IC50 值为 11.7 nM。

SMYD3-IN-1

SMYD3-IN-1 Chemical Structure

CAS No. : 2095160-79-3

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生物活性

SMYD3-IN-1 (compound 29) is an irreversible and selective inhibitor of SMYD3 (SET and MYND domain containing 3), with an IC50 of 11.7 nM[1].

IC50 & Target[1]

SMYD3

11.7 nM (IC50)

分子量

507.02

Formula

C28H31ClN4O3
CAS 号

2095160-79-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Huang C, et al. Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3. ACS Med Chem Lett. 2019 May 23;10(6):978-984.

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Polyketomycin

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Polyketomycin 

Polyketomycin 是一种从链霉菌属中分离的四环醌糖苷抗生素。Polyketomycin 抑制革兰氏阳性细菌 (Gram-positive bacteria) 的生长，其 MIC 值小于 0.2 µg/mL。Polyketomycin 具有抗菌，抗癌，抗疟疾的作用。

Polyketomycin

Polyketomycin Chemical Structure

CAS No. : 200625-47-4

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

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生物活性

Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities[1][2][3].

IC50 & Target[1][2]

Traditional Cytotoxic Agents

 

体外研究
(In Vitro)

Polyketomycin exhibits growth inhibition against L1210 leukemia, EL-4 leukemia, P388 leukemia, Ehrlich carcinoma, IMC carcinoma, colon 26 adnocarcinoma, Meth A fibrosarcoma, FS-3 fibrosarcoma and B16-BL10 melanoma with IC50 values of 3.3 μg/mL, 2.1 μg/mL, 5.2 μg/mL, 1 μg/mL, 0.9 μg/mL, 1.8 μg/mL, 2.4 μg/mL, 1.5 μg/mL and 1.6 μg/mL, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

The acute toxicity (LD50, ip) of Polyketomycin in mice is estimated to be 6.25-12.5mg/kg[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

864.84

Formula

C44H48O18
CAS 号

200625-47-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Momose I, et al. Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1998 Jan;51(1):21-5.

    [2]. Daum M, et al. Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. Chembiochem. 2009 Apr 17;10(6):1073-83.

    [3]. Otoguro K, In vitro antimalarial activities of the microbial metabolites. J Antibiot (Tokyo). 2003 Mar;56(3):322-4.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

2-Hydroxychalcone

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

2-Hydroxychalcone 

2-hydroxychalcone 是一种天然黄酮，是一种抗氧化剂，抑制脂质过氧化。2-hydroxychalcone 通过下调 Bcl-2 诱导凋亡。2-Hydroxychalcone 可抑制NF-kB 的激活。

2-Hydroxychalcone

2-Hydroxychalcone Chemical Structure

CAS No. : 644-78-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].

体外研究
(In Vitro)

2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells[1].
2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

224.25

Formula

C15H12O2
CAS 号

644-78-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72.

    [2]. B Madan, et al. 2′-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34.

    [3]. BABITA MADAN, et al. 2-Hydroxychalcone Inhibits Nuclear Factor-kB and Blocks Tumor Necrosis Factor-a- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol 58:526–534, 2000.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Polyketomycin

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Polyketomycin 

Polyketomycin 是一种从链霉菌属中分离的四环醌糖苷抗生素。Polyketomycin 抑制革兰氏阳性细菌 (Gram-positive bacteria) 的生长，其 MIC 值小于 0.2 µg/mL。Polyketomycin 具有抗菌，抗癌，抗疟疾的作用。

Polyketomycin

Polyketomycin Chemical Structure

CAS No. : 200625-47-4

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities[1][2][3].

IC50 & Target[1][2]

Traditional Cytotoxic Agents

 

体外研究
(In Vitro)

Polyketomycin exhibits growth inhibition against L1210 leukemia, EL-4 leukemia, P388 leukemia, Ehrlich carcinoma, IMC carcinoma, colon 26 adnocarcinoma, Meth A fibrosarcoma, FS-3 fibrosarcoma and B16-BL10 melanoma with IC50 values of 3.3 μg/mL, 2.1 μg/mL, 5.2 μg/mL, 1 μg/mL, 0.9 μg/mL, 1.8 μg/mL, 2.4 μg/mL, 1.5 μg/mL and 1.6 μg/mL, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

The acute toxicity (LD50, ip) of Polyketomycin in mice is estimated to be 6.25-12.5mg/kg[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

864.84

Formula

C44H48O18
CAS 号

200625-47-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Momose I, et al. Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1998 Jan;51(1):21-5.

    [2]. Daum M, et al. Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. Chembiochem. 2009 Apr 17;10(6):1073-83.

    [3]. Otoguro K, In vitro antimalarial activities of the microbial metabolites. J Antibiot (Tokyo). 2003 Mar;56(3):322-4.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

2-Hydroxychalcone

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

2-Hydroxychalcone 

2-hydroxychalcone 是一种天然黄酮，是一种抗氧化剂，抑制脂质过氧化。2-hydroxychalcone 通过下调 Bcl-2 诱导凋亡。2-Hydroxychalcone 可抑制NF-kB 的激活。

2-Hydroxychalcone

2-Hydroxychalcone Chemical Structure

CAS No. : 644-78-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].

体外研究
(In Vitro)

2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells[1].
2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

224.25

Formula

C15H12O2
CAS 号

644-78-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72.

    [2]. B Madan, et al. 2′-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34.

    [3]. BABITA MADAN, et al. 2-Hydroxychalcone Inhibits Nuclear Factor-kB and Blocks Tumor Necrosis Factor-a- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol 58:526–534, 2000.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pericyclivine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pericyclivine 

Pericyclivine 是一种从 Catharanthus Roseus 中分离出来的单体吲哚生物碱，具有抗癌作用。

Pericyclivine

Pericyclivine Chemical Structure

CAS No. : 975-77-9

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Pericyclivine is a monomeric indole alkaloid isolated from Catharanthus Roseus. Pericyclivine has anticancer effects[1][2].

体外研究
(In Vitro)

Pericyclivine shows cytotoxicity against the P-388 cell culture system with an ED50 of 13 μg/mL[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

322.40

Formula

C20H22N2O2
CAS 号

975-77-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. S Mukhopadhyay, et al. Catharanthus Alkaloids. XXXVI. Isolation of Vincaleukoblastine (VLB) and Periformyline From Catharanthus Trichophyllus and Pericyclivine From Catharanthus Roseus. J Nat Prod. May-Jun 1981;44(3):335-9.

    [2]. D G Kingston, et al. Plant Anticancer Agents V: New Bisindole Alkaloids From Tabernaemontana Johnstonii Stem Bark. J Pharm Sci. 1978 Feb;67(2):249-51.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pericyclivine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pericyclivine 

Pericyclivine 是一种从 Catharanthus Roseus 中分离出来的单体吲哚生物碱，具有抗癌作用。

Pericyclivine

Pericyclivine Chemical Structure

CAS No. : 975-77-9

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Pericyclivine is a monomeric indole alkaloid isolated from Catharanthus Roseus. Pericyclivine has anticancer effects[1][2].

体外研究
(In Vitro)

Pericyclivine shows cytotoxicity against the P-388 cell culture system with an ED50 of 13 μg/mL[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

322.40

Formula

C20H22N2O2
CAS 号

975-77-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. S Mukhopadhyay, et al. Catharanthus Alkaloids. XXXVI. Isolation of Vincaleukoblastine (VLB) and Periformyline From Catharanthus Trichophyllus and Pericyclivine From Catharanthus Roseus. J Nat Prod. May-Jun 1981;44(3):335-9.

    [2]. D G Kingston, et al. Plant Anticancer Agents V: New Bisindole Alkaloids From Tabernaemontana Johnstonii Stem Bark. J Pharm Sci. 1978 Feb;67(2):249-51.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pericyclivine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pericyclivine 

Pericyclivine 是一种从 Catharanthus Roseus 中分离出来的单体吲哚生物碱，具有抗癌作用。

Pericyclivine

Pericyclivine Chemical Structure

CAS No. : 975-77-9

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Pericyclivine is a monomeric indole alkaloid isolated from Catharanthus Roseus. Pericyclivine has anticancer effects[1][2].

体外研究
(In Vitro)

Pericyclivine shows cytotoxicity against the P-388 cell culture system with an ED50 of 13 μg/mL[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

322.40

Formula

C20H22N2O2
CAS 号

975-77-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. S Mukhopadhyay, et al. Catharanthus Alkaloids. XXXVI. Isolation of Vincaleukoblastine (VLB) and Periformyline From Catharanthus Trichophyllus and Pericyclivine From Catharanthus Roseus. J Nat Prod. May-Jun 1981;44(3):335-9.

    [2]. D G Kingston, et al. Plant Anticancer Agents V: New Bisindole Alkaloids From Tabernaemontana Johnstonii Stem Bark. J Pharm Sci. 1978 Feb;67(2):249-51.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Igovomab

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Igovomab 

Igovomab 是一种用于成像的单克隆抗体。Igovomab 可用于卵巢癌研究。

Igovomab

Igovomab Chemical Structure

CAS No. : 171656-50-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Igovomab is a monoclonal antibody for imaging. Igovomab can be used for ovarian cancer research[1].

CAS 号

171656-50-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. John Williams, et al. A monoclonal antibody framework binding interface for meditopes, meditope delivery systems and methods for their use. WO2012048332A2.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Flutax-2

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Flutax-2 

FLUTAX-2 是紫杉醇的活性荧光衍生物。FLUTAX-2 与聚合的 α,β 微管蛋白二聚体结合。FLUTAX-2 能够稳定 T. gallinae 和 T. foetus 滋养体的微管。

Flutax-2

Flutax-2 Chemical Structure

CAS No. : 301844-13-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

FLUTAX-2 is an active fluorescent derivative of Taxol. FLUTAX-2 binds to polymerized α,β-tubulin dimers. FLUTAX-2 is able to stabilize microtubules of intact T. gallinae and T. foetus trophozoites[1].

分子量

1319.27

Formula

C71H64F2N2O21
CAS 号

301844-13-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. P B Vieira, et al. Analysis of microtubule cytoskeleton distribution using a fluorescent taxoid in two trichomonadid protozoa: Trichomonas gallinae and Tritrichomonas foetus. Exp Parasitol. 2008 May;119(1):186-91.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Flutax-2

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Flutax-2 

FLUTAX-2 是紫杉醇的活性荧光衍生物。FLUTAX-2 与聚合的 α,β 微管蛋白二聚体结合。FLUTAX-2 能够稳定 T. gallinae 和 T. foetus 滋养体的微管。

Flutax-2

Flutax-2 Chemical Structure

CAS No. : 301844-13-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

FLUTAX-2 is an active fluorescent derivative of Taxol. FLUTAX-2 binds to polymerized α,β-tubulin dimers. FLUTAX-2 is able to stabilize microtubules of intact T. gallinae and T. foetus trophozoites[1].

分子量

1319.27

Formula

C71H64F2N2O21
CAS 号

301844-13-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. P B Vieira, et al. Analysis of microtubule cytoskeleton distribution using a fluorescent taxoid in two trichomonadid protozoa: Trichomonas gallinae and Tritrichomonas foetus. Exp Parasitol. 2008 May;119(1):186-91.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Flutax-2

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Flutax-2 

FLUTAX-2 是紫杉醇的活性荧光衍生物。FLUTAX-2 与聚合的 α,β 微管蛋白二聚体结合。FLUTAX-2 能够稳定 T. gallinae 和 T. foetus 滋养体的微管。

Flutax-2

Flutax-2 Chemical Structure

CAS No. : 301844-13-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

FLUTAX-2 is an active fluorescent derivative of Taxol. FLUTAX-2 binds to polymerized α,β-tubulin dimers. FLUTAX-2 is able to stabilize microtubules of intact T. gallinae and T. foetus trophozoites[1].

分子量

1319.27

Formula

C71H64F2N2O21
CAS 号

301844-13-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. P B Vieira, et al. Analysis of microtubule cytoskeleton distribution using a fluorescent taxoid in two trichomonadid protozoa: Trichomonas gallinae and Tritrichomonas foetus. Exp Parasitol. 2008 May;119(1):186-91.

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Symphytine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Symphytine 

Symphytine 从 Symphytum officinale 中分离出来一种吡啶生物碱，具有致癌性。

Symphytine

Symphytine Chemical Structure

CAS No. : 22571-95-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Symphytine is a pyrrolizidine alkaloid isolated from Symphytum officinale and has carcinogenicity[1].
体内研究
(In Vivo)

Symphytine (intraperitoneal injection; 13 mg/kg; 330 days) leads to survival for more than 330 days after the start of injections. Four of 20 rats (20%) had liver tumors: three has hemangioendothelial sarcoma and 1 has liver cell adenoma[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male inbred ACI rats[1]
Dosage: 13 mg/kg
Administration: Intraperitoneal injection; 330 days
Result: Led to hepatic tumor in rats.

分子量

381.46

Formula

C20H31NO6
CAS 号

22571-95-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hirono,et al.Induction of Hepatic Tumors in Rats by Senkirkine and Symphytine. J Natl Cancer Inst. 1979 Aug;63(2):469-72.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Symphytine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Symphytine 

Symphytine 从 Symphytum officinale 中分离出来一种吡啶生物碱，具有致癌性。

Symphytine

Symphytine Chemical Structure

CAS No. : 22571-95-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Symphytine is a pyrrolizidine alkaloid isolated from Symphytum officinale and has carcinogenicity[1].
体内研究
(In Vivo)

Symphytine (intraperitoneal injection; 13 mg/kg; 330 days) leads to survival for more than 330 days after the start of injections. Four of 20 rats (20%) had liver tumors: three has hemangioendothelial sarcoma and 1 has liver cell adenoma[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male inbred ACI rats[1]
Dosage: 13 mg/kg
Administration: Intraperitoneal injection; 330 days
Result: Led to hepatic tumor in rats.

分子量

381.46

Formula

C20H31NO6
CAS 号

22571-95-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hirono,et al.Induction of Hepatic Tumors in Rats by Senkirkine and Symphytine. J Natl Cancer Inst. 1979 Aug;63(2):469-72.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Symphytine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Symphytine 

Symphytine 从 Symphytum officinale 中分离出来一种吡啶生物碱，具有致癌性。

Symphytine

Symphytine Chemical Structure

CAS No. : 22571-95-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Symphytine is a pyrrolizidine alkaloid isolated from Symphytum officinale and has carcinogenicity[1].
体内研究
(In Vivo)

Symphytine (intraperitoneal injection; 13 mg/kg; 330 days) leads to survival for more than 330 days after the start of injections. Four of 20 rats (20%) had liver tumors: three has hemangioendothelial sarcoma and 1 has liver cell adenoma[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male inbred ACI rats[1]
Dosage: 13 mg/kg
Administration: Intraperitoneal injection; 330 days
Result: Led to hepatic tumor in rats.

分子量

381.46

Formula

C20H31NO6
CAS 号

22571-95-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hirono,et al.Induction of Hepatic Tumors in Rats by Senkirkine and Symphytine. J Natl Cancer Inst. 1979 Aug;63(2):469-72.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cadein1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cadein1 

Cadein1 是一种异喹啉衍生物，在p53功能缺失的癌细胞中，可导致 G2/M 延迟和 caspase 依赖的凋亡。

Cadein1

Cadein1 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Cadein1, an isoquinolinium derivative, leads to a G2/M delay and caspase-dependent apoptosis in cancer cells with non- functional p53[1].

体外研究
(In Vitro)

Cadein1 may be a potent anti-cancer agent against human cancers, specifically p53-deficient cancers with functional MMR[1].
Cadein1 activates p38 in p53-defective cancer cells with functional MMR to induce cell death. Cadein1 (4 μM) induces p38 phosphorylation in a time-dependent manner in HeLa and HCT116-Ch3/E6 cells [1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

655.64

Formula

C33H48F2INO2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Eun Ryoung Jang, et al. A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway. J Biol Chem. 2010 Jan 29;285(5):2986-95.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cadein1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cadein1 

Cadein1 是一种异喹啉衍生物，在p53功能缺失的癌细胞中，可导致 G2/M 延迟和 caspase 依赖的凋亡。

Cadein1

Cadein1 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Cadein1, an isoquinolinium derivative, leads to a G2/M delay and caspase-dependent apoptosis in cancer cells with non- functional p53[1].

体外研究
(In Vitro)

Cadein1 may be a potent anti-cancer agent against human cancers, specifically p53-deficient cancers with functional MMR[1].
Cadein1 activates p38 in p53-defective cancer cells with functional MMR to induce cell death. Cadein1 (4 μM) induces p38 phosphorylation in a time-dependent manner in HeLa and HCT116-Ch3/E6 cells [1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

655.64

Formula

C33H48F2INO2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Eun Ryoung Jang, et al. A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway. J Biol Chem. 2010 Jan 29;285(5):2986-95.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Cadein1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Cadein1 

Cadein1 是一种异喹啉衍生物，在p53功能缺失的癌细胞中，可导致 G2/M 延迟和 caspase 依赖的凋亡。

Cadein1

Cadein1 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Cadein1, an isoquinolinium derivative, leads to a G2/M delay and caspase-dependent apoptosis in cancer cells with non- functional p53[1].

体外研究
(In Vitro)

Cadein1 may be a potent anti-cancer agent against human cancers, specifically p53-deficient cancers with functional MMR[1].
Cadein1 activates p38 in p53-defective cancer cells with functional MMR to induce cell death. Cadein1 (4 μM) induces p38 phosphorylation in a time-dependent manner in HeLa and HCT116-Ch3/E6 cells [1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

655.64

Formula

C33H48F2INO2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Eun Ryoung Jang, et al. A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway. J Biol Chem. 2010 Jan 29;285(5):2986-95.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Sempervirine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Sempervirine 

Sempervirine 是从 Gelsemium sempervirens 中分离得到的具有抗肿瘤活性的吲哚生物碱。Sempervirine 抑制 Raji、MDA-MB-231 和 HeLa 的肿瘤细胞 EC50 值分别为 2.7 μM、1.77 μM、1.96 μM。

Sempervirine

Sempervirine Chemical Structure

CAS No. : 549-92-8

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Sempervirine is an indole alkaloid isolated from Gelsemium sempervirens with anti-tumor activities. Sempervirine is against sempervirine-sensitive tumor cells with EC50 values of 2.7 μM, 1.77 μM, and 1.96 μM for Raji, MDA-MB-231 and HeLa cells, respectively[2].

分子量

272.34

Formula

C19H16N2
CAS 号

549-92-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Noriyuki Kogure, et al. Total synthesis and full NMR assignment of ourouparine, a yohimbane-type indole alkaloid isolated from Gelsemium sempervirens. Journal of Natural Medicines volume 

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Sempervirine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Sempervirine 

Sempervirine 是从 Gelsemium sempervirens 中分离得到的具有抗肿瘤活性的吲哚生物碱。Sempervirine 抑制 Raji、MDA-MB-231 和 HeLa 的肿瘤细胞 EC50 值分别为 2.7 μM、1.77 μM、1.96 μM。

Sempervirine

Sempervirine Chemical Structure

CAS No. : 549-92-8

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Sempervirine is an indole alkaloid isolated from Gelsemium sempervirens with anti-tumor activities. Sempervirine is against sempervirine-sensitive tumor cells with EC50 values of 2.7 μM, 1.77 μM, and 1.96 μM for Raji, MDA-MB-231 and HeLa cells, respectively[2].

分子量

272.34

Formula

C19H16N2
CAS 号

549-92-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Noriyuki Kogure, et al. Total synthesis and full NMR assignment of ourouparine, a yohimbane-type indole alkaloid isolated from Gelsemium sempervirens. Journal of Natural Medicines volume 

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务