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L-4-Oxalysine hydrochloride (Synonyms: L-4-噁溶菌素盐酸盐) 纯度: 97.10%
L-4-Oxalysine hydrochloride是从中国的链霉菌培养基中分离的天然物质，具有抗癌活性。
L-4-Oxalysine hydrochloride Chemical Structure
CAS No. : 118021-35-5
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| 1 mg | ￥1000 | In-stock | |
| 5 mg | 询价 | ||
| 10 mg | 询价 |
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| 生物活性 |
L-4-Oxalysine hydrochloride is a natural product isolated from the culture media of Streptomyces roseovirdofuscus in China which has shown antitumor activities. |
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| 体外研究 (In Vitro) |
Alpha-fetoprotein (AFP) is expressed in BEL-7404 human hepatoma cells and L-4-Oxalysine suppresses AFP mRNA expression in the cells[1]. L-4-oxalysine functionally antagonizes the a-fetoprotein-induced suppression of the mitogen- and one-way mixed lymphocyte culture-induced proliferation of spleen lymphocytes and interleukin-6 production by these cells in mice bearing the hepatoma-22 tumor[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
| 体内研究 (In Vivo) |
Tbe ultrastructural efects of different doses of L-4-Oxalysine on hepatocytes in mice are most serious at day 1 after stopping treatment. Mice are given ig L-4-oxalysine (I-677) 10, 50, and 100 mg/kg for 7 d. On day 8 the hepatocytes show accumulation of lipid droplets followed by loss of matrices in cytoplasm. The total area of lipid droplets is far less than 25% of mean section of hepatocytes. The injury of mitochondria and RER is only found in the groups of medium and high dose[1]. L-4-oxalysine inhibits the proliferation of some mouse implanted tumors and pulmonary metastasis of mouse Lewis lung carcinoma[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子量 |
184.62 |
| Formula |
C5H13ClN2O3 |
| CAS 号 |
118021-35-5 |
| 中文名称 |
L-4-噁溶菌素盐酸盐 |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| 参考文献 |
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| Animal Administration [1] |
Mice: Sixty mice are randomly and equally divided into 4 groups. One of the groups is given ig saline and the other are given ig 10, 50, 100 mg /kg for 7d. On day l, 7, 14, and 28 respectively after terminating the treatment, 3 mice of each group are killed and the samples are examined under transmission electron microscope[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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